21259-25-6

Basic information

• Product Name: N-(2-BENZOYL-4-CHLOROPHENYL)BENZENECARBOXAMIDE
• Synonyms: N-(2-BENZOYL-4-CHLOROPHENYL)BENZENECARBOXAMIDE;N-(2-benzoyl-4-chlorophenyl)benzamide
• CAS NO: 21259-25-6
• Molecular Formula: C₂₀H₁₄ClNO₂
• Molecular Weight: 335.78
• Mol File: 21259-25-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-BENZOYL-4-CHLOROPHENYL)BENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-BENZOYL-4-CHLOROPHENYL)BENZENECARBOXAMIDE(21259-25-6)
• EPA Substance Registry System: N-(2-BENZOYL-4-CHLOROPHENYL)BENZENECARBOXAMIDE(21259-25-6)

Safety Data

• Hazardous Substances Data: 21259-25-6(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 98-88-4 benzoyl chloride 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 18928-48-8 5-Chloro-2-isocyanatobenzoyl chloride 
• 100-58-3 phenylmagnesium bromide 
• 7033-51-4 6-chloro-2-phenyl-benzo[d][1,3]oxazin-4-one 
• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 77747-08-1 2-Benzoylamino-5-chlorbenzophenon-N-phenylimin 
• 27020-32-2 6-chloro-2,4-diphenyl-quinazoline 3-oxide 
• 30169-34-7 6-chloro-2,4-diphenyl-quinazoline 
• 13097-03-5 5-Chloro-3-phenylindazole 
• 52598-02-4 2,3-diphenyl-5-chloro-1H-indole 
• 77747-09-2 2-Benzoylamino-5-chlorbenzophenon-N-(n-butylimin) 
• 77747-07-0 2-Benzoylamino-5-chlorbenzophenon-N-(4-chlorphenyl)-imin 
• 146470-02-2 C₂₁H₁₈ClN₅O*ClH 
• 75092-48-7 6-Chlor-3-(4-chlorphenyl)-3,4-dihydro-2,4-diphenyl-4-hydroxychinazolin 
• 719-59-5 5-chloro-2-aminobenzophenone 

Relevant articles and documents

Chiral Phosphoric Acid Catalyzed Kinetic Resolution of 2-Amido Benzyl Alcohols: Asymmetric Synthesis of 4H-3,1-Benzoxazines

An efficient method for the asymmetric synthesis of 4H-3,1-benzoxazines was developed by kinetic resolution of 2-amido benzyl alcohols using chiral phosphoric acid catalyzed intramolecular cyclizations. A broad range of benzyl alcohols (both secondary and tertiary alcohols) were kinetically resolved with high selectivities, with an s factor of up to 94. Mechanistic studies were performed to elucidate the mechanism of these reactions, wherein the amide moieties reacted as the electrophiles. Gram-scale reaction and facile transformations of the chiral products demonstrate the potential of this method in asymmetric synthesis of biologically active chiral heterocycles.

Improved synthesis of 2-amino-5-chlorophenyl-2'-pyrrylketone, a key intermediate in the synthesis of HIV Tat-antagonists

The reaction of a 2-phenylbenzoxazinone with pyrryl Grignard reagent is very efficient compared with that of a 2-methylbenzoxazinone. The title compound was prepared from 5-chloroanthranilic acid via the 2-phenylbenzoxazinone in 92% overall yield. This method was also successfully applied to the synthesis of 2-aminobenzophenones.