181190-33-0

Basic information

• Product Name: Propanamide, N-[4-chloro-2-(trifluoroacetyl)phenyl]-2,2-dimethyl-
• CAS NO: 181190-33-0
• Molecular Formula: C13H13ClF3NO2
• Molecular Weight: 307.7
• Mol File: 181190-33-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Propanamide, N-[4-chloro-2-(trifluoroacetyl)phenyl]-2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N-[4-chloro-2-(trifluoroacetyl)phenyl]-2,2-dimethyl-(181190-33-0)
• EPA Substance Registry System: Propanamide, N-[4-chloro-2-(trifluoroacetyl)phenyl]-2,2-dimethyl-(181190-33-0)

Safety Data

• Hazardous Substances Data: 181190-33-0(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 1150561-03-7 N-[2-(trifluoroacetyl)phenyl]-2,2-dimethylpropionamide 
• 62662-74-2 N-(2-chlorophenyl)-2,2,2-trimethylacetamide 
• 3282-30-2 pivaloyl chloride 
• 95-51-2 o-chloroaniline 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 
• 383-63-1 ethyl trifluoroacetate, 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 
• 407-25-0 trifluoroacetic anhydride 
• 360-95-2 2,2,2-Trifluoro-1-morpholin-4-yl-ethanone 
• 431-47-0 trifluoroacetic acid-methyl ester 

Downstream Products

• 177530-94-8 (S)-N-(4-chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)pivalamide 
• 177530-95-9 (R)-N-(4-chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)pivalamide 
• 214353-17-0 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate 
• 177530-96-0 N-[4-chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl]pivalamide 
• 173676-59-0 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone hydrochloride 
• 177530-93-7 rac-efavirenz 
• 168834-43-3 6-amino-3-chloro-α-cyclopropylethynyl-α-(trifluoromethyl)benzyl alcohol 
• 154598-52-4 efavirenz 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 

Relevant articles and documents

Benzylidene succinimides as 3C synthons for the asymmetric tandem Mannich reaction/transamidation of cyclic trifluoromethyl ketimines to obtain F3C-containing polycyclic dihydroquinazolinones

By taking advantage of benzylidene succinimides as a new class of 3C synthons, a highly diastereo- and enantioselective tandem Mannich reaction/transamidation has been established by reacting them with cyclic trifluoromethylN-acyl ketimines. Using aCinchonaalkaloid-derived squaramide as the catalyst, the tandem reaction proceeded smoothly under mild conditions and afforded a range of F3C-containing chiral polycyclic dihydroquinazolinones with excellent results (up to 99% yield, all cases >20?:?1 dr, up to 99% ee).

A preparing method of an efavirenz intermediate

The invention provides a preparing method of an efavirenz intermediate, and relates to the technical field of compound preparation methods. The method includes performing amino protection on 2-halogenaniline (II), as a raw material, with acyl chloride; reacting the generated N-acyl-2-halogen-aniline (III) with metal magnesium to generate a Grignard reagent; then reacting the Grignard reagent witha trifluoroacetyl amine compound (IV) to obtain N-acyl-2-(trifluoroacetyl)aniline (V); then reacting the N-acyl-2-(trifluoroacetyl)aniline (V) with chlorine under the function of a catalyst to obtainN-acyl-4-chloro-2-(trifluoroacetyl)aniline (VI); and performing hydrolysis and salting to obtain 4-chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate (I). The method has characteristics of shortsynthetic steps, simple operation, high safety, a large raw material choosing range, and a high yield of the target product, and is suitable for large-scale industrial production.

Asymmetric autocatalysis enables an improved synthesis of efavirenz

(Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).