2152-44-5 Usage
Chemical Properties
White Solid
Originator
Valisone,Schering,US,1967
Uses
Different sources of media describe the Uses of 2152-44-5 differently. You can refer to the following data:
1. Betamethasone 17-Valerate is a corticosteroid with anti-inflammatory properties. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man.
2. Antiepileptic non-selective phosphodiesterase inhibitor
3. Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.
4. A potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties
Definition
ChEBI: A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester.
Indications
Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid.
Manufacturing Process
The valerate is made from betamethasone as a starting material as follows: A
suspension of 9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-
3,20-dione(betamethasone) (2 grams) in sodium dried benzene (500 ml) was
distilled vigorously for a few minutes, toluene-p-sulfonic acid monohydrate (30
mg) and methyl orthovalerate (5 ml) were added and distillation was
continued for 10 minutes. The mixture was then boiled under reflux for 1.5
hours after which time unreacted betamethasone alcohol (400 mg) was
removed by filtration. The benzene solution was treated with solid sodium
.bicarbonate and a few drops of pyridine, filtered and evaporated to dryness
at about 50°C. The residue, in ether, was filtered through grade III basic
alumina (20grams) to remove traces of unreacted betamethasone alcohol, the
ether removed in vacuo and the residue of crude betamethasone 17,21-
methyl orthovalerate was treated with acetic acid (20ml) and a few drops of
water and left overnight at room temperature.
The acetic acid solution was poured into water (100 ml) and extracted with
chloroform. The chloroform extracts were washed in turn with water, saturated
sodium bicarbonate solution and water, dried and evaporated in vacuo. The
residual gum was triturated with ether and a white crystalline solid (1.16
grams) isolated by filtration. Recrystallization from ether (containing a small
amount of acetone)-petroleum ether gave 9α-fluoro-11β,21-dihydroxy-16β-
methyl-17α-valeryloxypregna-1,4-diene-3,20-dione (871 mg) as fine needles.
Brand name
Betatrex (Savage); Luxiq (Connetics); Valisone (Schering).
Therapeutic Function
Corticosteroid
Biochem/physiol Actions
Betamethasone 17-valerate is a synthetic glucocorticoid. It exhibitstherapeutic effects against various allergic and inflammatory skin diseases. Betamethasone 17-valerate also possesses anti-inflammatory properties.
Check Digit Verification of cas no
The CAS Registry Mumber 2152-44-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,5 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2152-44:
(6*2)+(5*1)+(4*5)+(3*2)+(2*4)+(1*4)=55
55 % 10 = 5
So 2152-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19?,20?,21?,24-,25-,26-,27-/m0/s1
2152-44-5Relevant articles and documents
Cosmetic use of microorganism(s) for the treatment of scalp disorders
-
, (2010/03/02)
The present invention relates to a use of an effective amount of at least one probiotic microorganism and/or a fraction thereof and/or a metabolite thereof for preventing and/or treating dandruff disorders of the scalp, as well as a cosmetic process for preventing and/or treating a dandruff condition including the administration a first cosmetic active agent and of at least a second cosmetic active agent, topically, the said first and second cosmetic active agents being formulated in separate compositions, the first cosmetic active agent being chosen from probiotic microorganisms, and mixtures thereof, and the second cosmetic active agent being chosen from antidandruff active agents.
Amide derivatives and intermediates for the synthesis thereof
-
, (2008/06/13)
Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon (α,γ)-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2 : each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc. (wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3 : hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.
Process of selective solvolysis
-
, (2008/06/13)
The 17α-monoesters and 17α,21-diesters of corticosteriods are well known and represent nowadays the most efficient group of anti-inflammatory compounds for topical application, having minimal systemic action.
