21557-13-1

Basic information

• Product Name: 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE
• Synonyms: 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE;1-(4-phenylpiperazin-1-yl)ethan-1-one
• CAS NO: 21557-13-1
• Molecular Formula: C₁₂H₁₆N₂O
• Molecular Weight: 204.27
• Mol File: 21557-13-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 374.1 °C at 760 mmHg
• Flash Point: 171 °C
• Appearance: /
• Density: 1.11 g/cm³
• Vapor Pressure: 8.57E-06mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE(21557-13-1)
• EPA Substance Registry System: 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE(21557-13-1)

Safety Data

• Hazardous Substances Data: 21557-13-1(Hazardous Substances Data)

Usage

General Description

1-(4-Phenylpiperazin-1-yl)ethanone, also known as 1-(4-Phenyl-1-piperazinyl)ethanone or as 4-(1-Oxoethyl)-1-phenylpiperazine, is a chemical compound that belongs to the class of piperazine derivatives. It is a pale yellow to beige crystalline solid with a molecular formula of C14H18N2O and a molecular weight of 230.306 g/mol. 1-(4-Phenylpiperazin-1-yl)ethanone has been studied for its potential use as a pharmaceutical intermediate, and it may have applications in the field of medicinal chemistry. Additionally, it may have bioactive properties and could be of interest for research in the development of new drug compounds.

InChI:InChI=1/C12H16N2O/c1-11(15)13-7-9-14(10-8-13)12-5-3-2-4-6-12/h2-6H,7-10H2,1H3

Upstream product

• 67914-60-7 N-acetyl-N'-(4-hydroxyphenyl)piperazine 
• 60-35-5 acetamide 
• 92-54-6 4-phenyl-1-piperazine 
• 108-22-5 Isopropenyl acetate 
• 62-53-3 aniline 
• 43204-63-3 bis(2-bromoethyl)amine hydrobromide 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 127-19-5 N,N-dimethyl acetamide 

Downstream Products

• 102101-91-7 1-{4-[4-(4-Trifluoromethyl-phenylazo)-phenyl]-piperazin-1-yl}-ethanone 
• 90402-29-2 4,5-Dimethoxy-2-[1-(4-phenyl-piperazin-1-yl)-eth-(E)-ylideneamino]-benzonitrile 
• 102101-90-6 1-{4-[4-(4-Chloro-phenylazo)-phenyl]-piperazin-1-yl}-ethanone 
• 102101-88-2 1-{4-[4-(4-Methoxy-phenylazo)-phenyl]-piperazin-1-yl}-ethanone 
• 102101-93-9 1-{4-[4-(4-Nitro-phenylazo)-phenyl]-piperazin-1-yl}-ethanone 
• 102101-89-3 1-acetyl-4-(4-phenylazo-phenyl)-piperazine 
• 102101-92-8 4-[4-(4-Acetyl-piperazin-1-yl)-phenylazo]-benzonitrile 
• 90402-57-6 4-amino-6,7-dimethoxy-2(4-phenylpiperazino)quinoline 

Relevant articles and documents

Catalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines

Due to the directional nature of sp3-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp3)-C(sp3) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on our well-designed C-C single bond cleavage mechanism, we discovered a means of photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O2as a benign oxidant under very mild conditions. The utility of our methodology was demonstrated by the C(sp3)-C(sp3) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, our methodology is noteworthy, not only in that it does not require any catalysts, but also in that it provides valuable possibilities for the scalable functionalization of clinical drugs and natural products.

Nickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents

The nickel-catalyzed hydrodeoxygenation of aryl sulfamates has been developed with alcohols as mild reductants. A variety of functional groups and heterocycles were tolerated in this reaction system to give the desired products in high yields. In addition, the gram-scale process and stepwise cine-substitution were also achieved with high efficiency.

Protection of COOH and OH groups in acid, base and salt free reactions

We report an iron-catalyzed general functional group protection method with inexpensive reagents. This environmentally benign process does not use acids or bases, and does not produce waste products. Further purification beyond filtration and evaporation is, in most cases, unnecessary. Free COOH and OH groups can be protected in a one-pot reaction.