215934-32-0

Usage

Uses

Used in Pharmaceutical Industry:
Methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy-prop-2-enoate is used as a potential candidate for the development of new drugs in the pharmaceutical industry. Its unique structure and properties may allow it to target specific cellular pathways or receptors, offering novel therapeutic approaches for various diseases and conditions.
methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate's potential applications in the pharmaceutical industry could include:
1. Targeting specific cellular pathways or receptors involved in various diseases, such as cancer, inflammatory disorders, or neurological conditions.
2. Enhancing the efficacy of existing drugs by modifying their chemical structure or delivery methods.
3. Developing prodrugs that can be activated in the body to release the active compound, improving drug safety and selectivity.

InChI:InChI=1/C22H17N3O5/c1-27-13-17(22(26)28-2)16-8-4-6-10-19(16)30-21-11-20(24-14-25-21)29-18-9-5-3-7-15(18)12-23/h3-11,13-14H,1-2H3/b17-13+

Upstream product

• 131860-97-4 (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 611-20-1 salicylonitrile 
• 107-21-1 ethylene glycol 
• 1193-21-1 4,6-dichloropyrimidine 
• 143230-42-6 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropionic acid methyl ester 
• 478413-45-5 2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)acetic acid methyl ester 
• 107-31-3 Methyl formate 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 187327-30-6 2-[6-(trifluoromethyl)-2-pyridyloxymethyl]phenylacetic acid methyl ester 
• 95-56-7 2-hydroxybromobenzene 
• 103497-78-5 (E)-3-methoxy-2-(2-benzyloxyphenyl)acrylic acid methyl ester 
• 163041-47-2 (Z)-3-methoxy-2-iodo-acrylic acid methyl ester 

Downstream Products

• 143130-94-3 methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate 
• 240802-59-9 2-(6-hydroxypyrimidin-4-yloxy)benzonitrile 
• 1185255-09-7 (E)-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylic acid 
• 478413-45-5 2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)acetic acid methyl ester 
• 1193-24-4 4,6-pyrimidinediol 

Relevant academic research and scientific papers

Method for improving conversion rate of azoxystrobin

The invention discloses a method for improving the conversion rate of azoxystrobin. The method comprises the following steps: preparing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate; preparing o-hydroxybenzonitrile; mixing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate, o-hydroxybenzonitrile, potassium carbonate and ketene chloride according to a molar ratio of 30: 35: 50: 1.1, and dissolving the obtained mixture in dimethylformamide to obtain a mixed product; and heating the prepared mixed product, keeping the mixed product at a certain temperature, conducting filtering, carrying out reduced-pressure distillation, performing cooling, separating out crystals, carrying out filtering and washing and performing drying to obtain azoxystrobin. On the basis of the prior art, the synthesis of azoxystrobin is improved in the invention, so the yield of azoxystrobin is effectively increased, the conversion rate of the raw materials including methyl(E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy acrylate and o-hydroxybenzonitrile for azoxystrobin in the process of preparing azoxystrobin is effectively improved, and the production benefit of azoxystrobin is improved.

AN IMPROVED PROCESS FOR PREPARATION OF METHYL (2E)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE

The present invention relates to an improved processses for synthesizing preparing substituted cyanophenoxy-pyrimidinyloxy-phenyl acrylate derivatives. The present invention specifically relates to an improved process for the preparation of methyl (2E)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyacrylate having the following Formula I.

MENUFCACTURING METHOD OF AZOXYSTROBIN

MCMA ((E)- Methyl methyl methyl (2- ((6-chloropyrimidin-4-yl) oxy) phenyl).3 - methoxyacrylate). DABCO (1, 4-diazabicyclo [2.2.2] octane) and 2 - CP (2-cyanophenol) are mixed and fed into a reactor (z) by mixing into azoxystobin a continuous reactor and introducing them into a reactor.

PREPARATION METHOD FOR AZOXYSTROBIN AND INTERMEDIATE THEREOF

The present invention relates to the preparation field of azoxystrobin, and discloses a preparation method for a compound represented by formula (I). The method comprises the following steps: (1) a compound represented by formula (II) is hydrolyzed in a solvent under acidic conditions to obtain a compound represented by formula (III); and (2) the compound represented by formula (III) is reacted with a base and a methylating agent to obtain the compound represented by formula (I); in the formula, R3 is hydrogen or C1-C4 alkyl, and R4 is C1-C4 alkyl. The process for preparing azoxystrobin of the present invention not only successfully replaces trimethyl orthoformate and reduces the raw material cost, but also has high total reaction yield, and is suitable for industrial large-scale production. Experiments have proven that the yield of the prepared azoxystrobin can reach 95%.

METHOD FOR PREPARING AZOXYSTROBIN

A method for preparing azoxystrobin comprises the following steps: (a) mixing methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate, 2-cyanophenol, potassium carbonate, and 10-80 mol % of 1-methylpyrrolidine as a catalyst in an aprotic solvent to form a basic mixture, and reacting the basic mixture for 2-5 hrs at a temperature of 60-120° C.; and (b) subjecting the basic mixture after reaction in Step (a) to a first distillation under a reduced pressure of 80-120 torr at 70-80° C., to obtain azoxystrobin.

PROCESS FOR PREPARATION OF AZOXYSTROBIN AND INTERMEDIATES THEREOF

The present invention relates to a process for preparation of strobilurin compound, azoxystrobin and its intermediates using a catalyst selected from 1,8-Diazabicyclo[5.4.0]undec-7-ene or 1,5-Diazabicyclo[4.3.0]non-5-ene, salts thereof, or derivatives thereof.

PROCESS FOR THE PREPARATION OF FUNGICIDALLY ACTIVE STROBILURIN COMPOUNDS AND INTERMEDIATES THEREOF

The present invention relates to a process for the preparation of strobilurin of compounds of Formula (I) of and its intermediates using 1,5,7-triazabicyclo[4.4.0]dec-5-ene or salts thereof, or derivatives thereof as a catalyst. The present invention provides the compounds of formula (I) in high yield and high purity.

An azoxystrobin and its intermediate synthesis method

The invention discloses a synthesis method for azoxystrobin. The synthesis method comprises the following steps of reacting a mixed system containing (E)-methyl-2-[2-(6-chloropyrimidine-4-methoxy) phenyl]-3-methoxyacrylate and methyl 2-[2-(6-chloropyrimidine-4-methoxy) phenyl]-3,3-dimethoxypropanoate with 2-hydroxy-benzonitril in the presence of a catalyst, adding metal chloride, and performing heating reaction and post-treatment to obtain azoxystrobin. The synthesis method is mild in reaction condition, and reaction can be realized under the conditions of normal pressure and negative pressure; moreover, the use of a hypertoxic catalyst such as dimethyl sulfate is avoided in a reaction process, so that safety is greatly improved, and environmental pollution is greatly reduced; the synthesis method is pure in reaction, and fewer byproducts are produced.

Method for preparing azoxystrobin

The present invention provides a process for preparing azoxystrobin, which is performed by reacting 2-cyanophenol or a salt thereof with a compound represented by formula I under the catalysis of a trimethylamine catalyst to obtain the azoxystrobin represented by formula II, which allows the yield of the product azoxystrobin to reach 98% or more, the yield of separated product to reach 95% or more and the post-processing to be simple. The trimethylamine catalyst can be recycled and reused in synthesizing the target product azoxystrobin, which not only reduces the cost but also reduces the total nitrogen and COD in wastewater. The advantages regarding of cost and environmental protection of the method according to the present invention are significant and thus the method is suitable for industrial production.

A process for preparing a azoxystrobin or intermediate catalyst and preparation method (by machine translation)

The invention relates to a process for the preparation of azoxystrobin or intermediate catalyst, containing 1 - azabicyclo [2, 2, 2] octane structure on a series of compounds introduced into the amino or substituted amino, form the formula 10 structure shown or a salt thereof; the invention also relates to processes for preparing azoxystrobin or intermediates thereof, the present invention provides catalyst and preparation method, with process is easy to control, short reaction time, the conversion is high, and low energy consumption, and is suitable for large-scale industrial production. (by machine translation)