103497-78-5Relevant academic research and scientific papers
A concise synthesis of azoxystrobin using a Suzuki cross-coupling reaction
Liu, Yong-Gan,Luo, Yan,Lu, Yao
, p. 586 - 589 (2015)
A simple, efficient and eco-friendly process for the synthesis in good yield of azoxystrobin from 2-bromophenol has been developed using phenolic hydroxyl protection, Grignard reaction, Suzuki cross-coupling, hydrogenation and a nucleophilic reaction on a 2-chloropyrimidine.
Method for preparing azoxystrobin on basis of Suzuki reaction
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, (2016/10/10)
The invention relates to a method for preparing azoxystrobin on basis of a Suzuki reaction. The method comprises the following steps: dissolving a mixture composed of methyl (E)-2-[2-(6-chloropyrimidinyl-4-yloxo)phenyl]-3-methoxy acrylate, cesium carbonate and 2-cyanophenol according to a molar ratio of 1:2:2 in a solvent, stirring at 85DEG C under the protection of N2 for 7h, and separating and purifying the obtained mixture to prepare azoxystrobin. The novel green synthesis method provided by the invention has the advantages of low cost, high yield, simple process, and suitableness for mass production.
Measuring method for measuring and using a kit or flagment autoantibody autoantibody or fragments thereof, and their azoxystrobin deriv., azoxystrobin
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, (2016/10/20)
PROBLEM TO BE SOLVED: To provide a method for measuring the levels of an azoxystrobin as a fungicide left in samples such as of farm products or processed products. SOLUTION: An antibody specific to azoxystrobin is obtained by using a composite, as an immunogen, of an azoxystrobin derivative and a polymeric compound. The method for assaying azoxystrobin using such an antibody is provided. An assay kit therefor is prepared. COPYRIGHT: (C)2011,JPOandINPIT
Concise and modular synthesis of regioisomeric haptens for the production of high-affinity and stereoselective antibodies to the strobilurin azoxystrobin
Parra, Javier,Mercader, Josep V.,Agulló, Consuelo,Abad-Fuentes, Antonio,Abad-Somovilla, Antonio
experimental part, p. 624 - 635 (2011/03/19)
The immune response to regioisomeric haptens of azoxystrobin with varied derivatization sites was studied. Based on the Sonogashira and Suzuki-Miyaura couplings and following a straightforward modular design, we have synthesized four haptens with the same linker anchored through C-C bonds and located at different sites of the molecule. The most stereoselective antibodies were produced from immunogens with the spacer arm at a distal position from the β-methoxyacrylate moiety characteristic of strobilurins. Moreover, we observed that assay cross-reactivity was reliant on the functionalization site of the competitor derivative. Finally, the antibody binding site was explored using synthetic chemical analogues.
CHEMICAL PROCESS
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Page/Page column 25-26, (2010/11/24)
The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenol, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1 ,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of l,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(CO 2CH 3)=CHOCH 3 or the methyl 2-(3,3-dimethoxy)propanoate group C(CO 2CH 3)CH(OCH 3) 2, or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them.
Certain 2-pyridyl oxy-phenyl acrylates having fungicidal, insecticidal, nematocidal and plant growth regulating activity
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, (2008/06/13)
This invention relates to derivatives of acrylic acid useful in agriculture (especially as fungicides but also as plant growth regulators, insecticides and nematocides), to processes for preparing them, to agricultural (especially fungicidal) compositions containing them, and to methods of using them to combat fungi, especially fungal infections in plants, to regulate plant growth and to kill or control insect or nematode pests. The invention provides a compound having the formula (I): STR1 and stereoisomers thereof, wherein W is a substituted pyridinyl or substituted pyrimidinyl group linked to A by any of its ring carbon atoms; A is either an oxygen atom or S(O)n wherein n is 0, 1 or 2; X, Y and Z, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl (including haloalkyl), optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, (including haloalkoxy), optionally substituted alkylthio, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted acyloxy, optionally substituted amino, optionally substituted acylamino, nitro, cyano, --CO2 R3, --CONR4 R5, --COR6 or --S(O)m R7 (wherein m is 0, 1 or 2) groups, or any two of the groups X, Y and Z, when they are in adjacent positions on the phenyl ring, may join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; R1 and R2, which are the same or different, are optionally substituted alkyl (including fluoroalkyl) groups provided that when W is 5-trifluoromethylpyridin-2-yl, A is oxygen, X is hydrogen, and R1 and R2 are both methyl, Y and Z are not both hydrogen, Y is not F, Cl, methyl, nitro, 5--CF3, 5--SCH3 or 4--(CH3)2 N if Z is hydrogen and Y and Z together are not 3-nitro-5-chloro, 3,5-dinitro, 4,5-dimethoxy or 4,5-methylenedioxy; and R3, R4, R5, R6 and R7, which are the same or different, are hydrogen atoms or optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted aralkyl groups; and metal complexes thereof.
