21685-47-2

Usage

Uses

Used in Organic Synthesis:
D-Valine methyl ester hydrochloride serves as a valuable intermediate in organic synthesis, facilitating the creation of complex molecules and contributing to the development of novel chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, D-Valine methyl ester hydrochloride is utilized as a key intermediate for the production of a range of drugs and pharmaceuticals. Its properties make it instrumental in the synthesis of bioactive compounds and therapeutic agents.
Used in Drug Development:
D-Valine methyl ester hydrochloride is employed in drug development processes to construct new pharmaceutical compounds with potential therapeutic benefits, highlighting its importance in advancing medical treatments.

Upstream product

• 67-56-1 methanol 
• 640-68-6 D-Val-OH 
• 5619-05-6 DL-valine methyl ester hydrochloride 
• 432550-82-8 N-benzoyl-N-ethanoylamino-2-[(S)-1-tert-butyldimethylsilyloxy-2-methylpropyl]quinazolin-4(3H)-one 
• 952524-02-6 (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole 
• 4070-48-8 L-valine methyl ester 
• 13803-83-3 (R)-3-Methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid methyl ester 
• 914467-24-6 (2S,5R)-5-isopropyl-3,6-dimethoxy-2-methyl-2-(2-(pyrrolidin-1-yl)ethyl)-2,5-dihydropyrazine 
• 914467-22-4 2-((2S,5R)-2-(cyclopropylmethyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl)-N,N-dimethylethanamine 
• 914467-17-7 2-((2S,5R)-5-isopropyl-3,6-dimethoxy-2-methyl-2,5-dihydropyrazin-2-yl)-N,N-dimethylethanamine 
• 109838-85-9 (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine 
• 590-86-3 isovaleraldehyde 
• 218443-10-8 2,2'-(butane-1,4-diyl)bis<(2S,5R)-2,5'-dihydro-3,6-dimethoxy-5-isopropylpyrazine> 
• 170984-22-2 1,4-bis[(2R,5S)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-methylpyrazin-5-yl]butane 

Downstream Products

• 114252-89-0 N-[(S)-2-methoxycarbonyl-2-(2-phenyl-acetylamino)-ethyl]-D-valine methyl ester 
• 114252-89-0 N-[(R)-2-methoxycarbonyl-2-(2-phenyl-acetylamino)-ethyl]-D-valine methyl ester 
• 83703-80-4 Z-Ala-D-Val-OMe 
• 1189337-20-9 N-(N-benzyloxycarbonyl-L-leucyl)-D-valine methyl ester 
• 55325-57-0 N-(N-benzyloxycarbonyl-L-seryl)-D-valine methyl ester 
• 83703-82-6 N-[N-(toluene-4-sulfonyl)-L-valyl]-D-valine methyl ester 
• 32526-16-2 D-valine amide 
• 102921-40-4 C₂₄H₂₃NO₈ 
• 112157-47-8 Z-Gly-D-ValOMe 
• 83703-76-8 N-[N-(toluene-4-sulfonyl)-D-valyl]-D-valine methyl ester 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 106391-85-9 (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate 
• 477908-20-6 (2R)-3-methyl-2-[(4-nitrobenzenesulfonyl)amino]butanoic acid methyl ester 
• 876133-31-2 methyl N'-(tert-butoxycarbonyl)-L-phenylalanyl-D-valinate 

Relevant academic research and scientific papers

N-Pyrazinoyl substituted amino acids as potential antimycobacterial agents-the synthesis and biological evaluation of enantiomers

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds containing a fragment of the first-line antitubercular drug pyrazinamide (PZA), coupled with methyl or ethyl esters of selected amino acids. The antimicrobial activity was evaluated on a variety of (myco)bacterial strains, including Mtb H37Ra, M. smegmatis, M. aurum, Staphylococcus aureus, Pseudomonas aeruginosa, and fungal strains, including Candida albicans and Aspergillus flavus. Emphasis was placed on the comparison of enantiomer activities. None of the synthesized compounds showed any significant activity against fungal strains, and their antibacterial activities were also low, the best minimum inhibitory concentration (MIC) value was 31.25 μM. However, several compounds presented high activity against Mtb. Overall, higher activity was seen in derivatives containing l-amino acids. Similarly, the activity seems tied to the more lipophilic compounds. The most active derivative contained phenylglycine moiety (PC-d/l-Pgl-Me, MIC 1.95 μg/mL). All active compounds possessed low cytotoxicity and good selectivity towards Mtb. To the best of our knowledge, this is the first study comparing the activities of the d- and l-amino acid derivatives of pyrazinamide as potential antimycobacterial compounds.

Exciton-Coupled Circular Dichroism Characterization of Monotopically Binding Guests in Host?Guest Complexes with a Bis(zinc porphyrin) Tweezer

A stiff-stilbene-linked bisporphyrin tweezer with inherent helicity was used for exciton-coupled circular dichroism (ECCD) characterization of a series of monotopically binding amine guest molecules. CD signals were observed for a variety of monoamines at relatively low tweezer/amine (host/guest) ratios between 1 : 10 to 1 : 70. For the amines producing the most intense CD signals, a binding stoichiometry of 1 : 2 was found. A likely explanation is the presence of guest-guest interactions in the complexes. This is supported by the correlation observed between CD signal intensity and magnitude of possible noncovalent binding between the guests, which can be divided into three groups showing no, moderate and strong response, respectively. Further support for this rationalization comes from molecular modelling.

Method for preparing amino ether compounds

The invention belongs to the technical field of organic synthesis and relates to a method for preparing amino ether compounds. The method comprises the following steps: by taking amino alcohol as a raw material, protecting amino in the amino alcohol so as to obtain Schiff base; carrying out an etherification reaction on the hydroxyl group in the Schiff base; and finally, performing amino deprotection, thereby obtaining corresponding amino ethers. The method disclosed by the invention has high regio-selectivity, the substrates of higher than 99.9% are subjected to etherification reaction, the reaction conversion ratio of each step is higher than 99.8%, and the total yield is higher than 95%; when amino alcohol is chiral, the amino ethers with retention of configuration can be obtained; and moreover, each step of the method is a conventional operation, the process cost is low, and three wastes are few, the energy consumption is low, an environment-friendly effect is achieved, and large-scale industrial production is easily realized.

STABILIZED POLYPEPTIDES AND USES THEREOF

The present invention provides inventive stabilized STAT polypeptides, pharmaceutical compositions thereof, and methods of making and using inventive stabilized STAT polypeptides.

In situ deprotection and incorporation of unnatural amino acids during cell-free protein synthesis

The S30 extract from E. coli BL21 Star (DE3) used for cell-free protein synthesis removes a wide range of α-amino acid protecting groups by cleaving α-carboxyl hydrazides; methyl, benzyl, tert-butyl, and adamantyl esters; tert-butyl and adamantyl carboxamides; α-amino form-, acet-, trifluoroacet-, and benzamides and sidechain hydrazides and esters. The free amino acids are produced and incorporated into a protein under standard conditions. This approach allows the deprotection of amino acids to be carried out in situ to avoid separate processing steps. The advantages of this approach are demonstrated by the efficient incorporation of the chemically intractable (S)-4-fluoroleucine, (S)-4,5- dehydroleucine, and (2S,3R)-4-chlorovaline into a protein through the direct use of their respective precursors, namely, (S)-4-fluoroleucine hydrazide, (S)-4,5-dehydroleucine hydrazide, and (2S,3R)-4-chlorovaline methyl ester. These results also show that the fluoroand dehydroleucine and the chlorovaline are incorporated into a protein by the normal biosynthetic machinery as substitutes for leucine and isoleucine, respectively. Copyright

Enantioselective benzoylation of α-amino esters using (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole, a chiral benzimidazolide

(Chemical Equation Presented) A new chiral benzimidazolide is developed as a nonenzymatic acylating agent for enantioselective benzoylation of racemic α-amino esters. The process is highly efficient, which exhibits uniformly high enantioselectivity for α-amino esters with or without aryl substituents under mild reaction conditions. The chiral benzimidazolide is inexpensive and is easily accessible.

P38 inhibitors and methods of use thereof

Inhibitors of p38 and methods for producing these inhibitors are provided. Also provided are pharmaceutical compositions comprising the inhibitors of the invention, methods of utilizing the inhibitors and pharmaceutical compositions comprising said inhibi

Stereoselective synthesis of δ-heteroaryl substituted β-hydroxy-γ,δ-unsaturated α-amino acids

Enantiomerically pure δ-heteroaryl substituted β-hydroxy-γ,δ-unsaturated α-amino acids were stereoselectively synthesized starting from (2R)-(+)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine (Schoellkopf's reagent) and suitable β-heteroaryl-α,β-unsaturate

Compositions and methods for selectively binding amines or amino acid enantiomers over their counter-enantiomers

Naphthyl crown ether ligand molecules containing at least two naphthyl groups that are covalently bonded to suitable solid supports and coated by hydrophobic organic solvents are disclosed. These compositions and associated methods are characterized by selectivity of desired amine or amino acid enantiomers over their counter-enantiomers and derivatives. The composition preferably has an α-value greater than or equal to 4. This allows for the separation of such enantiomers with nonchromatographic resin bed separations of three separation stages or less.