219788-52-0

Upstream product

• 106-95-6 allyl bromide 
• 113806-30-7 (2R,4S)-3-benzoyl-4-benzyl-2-phenyloxazolidin-5-one 
• 98-88-4 benzoyl chloride 
• 100-52-7 benzaldehyde 
• 63-91-2 L-phenylalanine 

Downstream Products

• 544676-36-0 N-(4-benzyl-3-oxo-2,3,4,5-tetrahydro-pyridazin-4-yl)-benzamide 
• 544676-35-9 (S)-2-Benzoylamino-2-benzyl-4-oxo-butyric acid methyl ester 
• 544676-37-1 N-(4-benzyl-3-oxo-hexahydro-pyridazin-4-yl)-benzamide 
• 219788-64-4 (2R)-2-(allyl-benzoyl-amino)-2-benzyl-pent-4-enoic acid methyl ester 
• 219788-71-3 (2R)-1-benzoyl-2-benzyl-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid methyl ester 
• 219788-58-6 (R)-2-Benzoylamino-2-benzyl-pent-4-enoic acid methyl ester 

Relevant academic research and scientific papers

A diastereoselective synthesis of the tetrahydropyridazinone core of 2-oxo-1,6-diazobicyclo[4.3.0]nonane-9-carboxylate-based peptidomimetics starting from (S)-phenylalanine

A diastereoseletvive synthesis of a peptidic tetrahydropyridazinone 10 from (S)-phenylalanine is reported. This derivative was then converted to the bicyclic peptidomimetic 11, an important class of β-strand mimetic.

Synthesis and X-ray structure of a 1,2,3,6-tetrahydropyridine-based phenylalanine mimetic

A ring-closing metathesis reaction on methyl (2R)-(N-allyl-N- benzoylamino)-2-benzylpent-4-enoate 5, prepared as a single isomer from L- phenylalanine, gave a conformationally restricted 1,2,3,6- tetrahydropyridine-based phenylalanine mimetic 6 in good yi