40525-65-3

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-(PHENYLMETHOXY)-BENZENEACETATE is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 2-(PHENYLMETHOXY)-BENZENEACETATE is utilized as a precursor in the production of certain agrochemicals, potentially aiding in the development of pesticides or other agricultural chemicals.
Used in Fragrance and Flavor Production:
METHYL 2-(PHENYLMETHOXY)-BENZENEACETATE is employed as a key component in the creation of fragrances and flavors, capitalizing on its chemical properties to enhance or create specific scents and tastes in various products.

InChI:InChI=1/C16H16O3/c1-18-16(17)11-14-9-5-6-10-15(14)19-12-13-7-3-2-4-8-13/h2-10H,11-12H2,1H3

Upstream product

• 67-56-1 methanol 
• 22047-88-7 2-hydroxyphenylacetic acid benzyl ether 
• 108-94-1 cyclohexanone 
• 22446-37-3 methyl (2-hydroxyphenyl)acetate 
• 100-39-0 benzyl bromide 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 74-88-4 methyl iodide 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 90-02-8 salicylaldehyde 
• 23915-08-4 2-benzyloxybenzyl chloride 
• 92552-22-2 (2-benzyloxyphenyl)acetonitrile 
• 3381-87-1 2-benzyloxybenzyl alcohol 
• 90-01-7 salicylic alcohol 

Downstream Products

• 881672-71-5 dimethyl 2-[2-(benzyloxy)benzyl]malonate 
• 369386-17-4 (2S,3S)-methyl 2-phenyl-2,3-dihydrobenzofuran-3-carboxylate 
• 737766-28-8 (2S,3R)-2-phenyl-3-methoxycarbonyl-2,3-dihydrobenzofuran 
• 103497-78-5 (E)-3-methoxy-2-(2-benzyloxyphenyl)acrylic acid methyl ester 
• 103474-03-9 methyl 3-hydroxy-2-[2'-benzyloxyphenyl]propenoate 
• 56052-43-8 2-(2-Benzyloxyphenyl)ethanol 
• 114077-42-8 (E)-3-methoxy-2-(2-hydroxyphenyl)-acrylic acid methyl ester 
• 131860-97-4 (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate 
• 70794-13-7 2-(1H-indol-3-yl)phenol 
• 179253-16-8 2-(2-(benzyloxy)phenyl)acetaldehyde 
• 553-86-6 benzofuran-2(3H)-one 

Relevant academic research and scientific papers

Metal-Free Tandem Rearrangement/Lactonization: Access to 3,3-Disubstituted Benzofuran-2-(3H)-ones

A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(3H)-ones through reacting α-aryl-α-diazoacetates with triarylboranes is presented. Initially, triarylboranes were successfully investigated in α-arylations of α-diazoacetates, however in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes an intramolecular rearrangement to form a quaternary center. The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuranones in good yields.

(2-Benzyloxyphenyl)acetyl (BnPAc): A Participating Relay Protecting Group for Diastereoselective Glycosylation and the Synthesis of 1,2-trans Glycosyl Esters

The (2-benzyloxyphenyl)acetyl group has been identified as a new protecting group for hydroxyl functions. Various alcohols could be easily protected with high yields, and deprotection was achieved by a relay approach using Pd/H 2 in combination with 1,8-bis(dimethylamino)naphthalene, conditions that are orthogonal to ester groups. The new protecting group is stable in glycosylation reactions demonstrating an effective neighboring group participation leading to the exclusive formation of 1,2-trans glycosides and glycosyl esters.

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety

A series of CAPE derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE's antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50?=?0.4?±?0.02 & 0.6?±?0.03?μM against Hela and DU-145 respectively).

Measuring method for measuring and using a kit or flagment autoantibody autoantibody or fragments thereof, and their azoxystrobin deriv., azoxystrobin

PROBLEM TO BE SOLVED: To provide a method for measuring the levels of an azoxystrobin as a fungicide left in samples such as of farm products or processed products. SOLUTION: An antibody specific to azoxystrobin is obtained by using a composite, as an immunogen, of an azoxystrobin derivative and a polymeric compound. The method for assaying azoxystrobin using such an antibody is provided. An assay kit therefor is prepared. COPYRIGHT: (C)2011,JPOandINPIT

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands

A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.

Endothelin antagonists

A compound of formula (I), in which: R1is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2is hydrogen, hydroxy or protected h

A new synthesis for methyl 2-benzyloxylphenylacetate

A new synthetic method for methyl 2-benzyloxylphenylacetate, a key intermediate of a new type of fungicides, had been found, which has only 3 steps. The 80% yield of the new method is a major improvement over the 30% 6- step-process reported by the literature.

Certain 2-pyridyl oxy-phenyl acrylates having fungicidal, insecticidal, nematocidal and plant growth regulating activity

This invention relates to derivatives of acrylic acid useful in agriculture (especially as fungicides but also as plant growth regulators, insecticides and nematocides), to processes for preparing them, to agricultural (especially fungicidal) compositions containing them, and to methods of using them to combat fungi, especially fungal infections in plants, to regulate plant growth and to kill or control insect or nematode pests. The invention provides a compound having the formula (I): STR1 and stereoisomers thereof, wherein W is a substituted pyridinyl or substituted pyrimidinyl group linked to A by any of its ring carbon atoms; A is either an oxygen atom or S(O)n wherein n is 0, 1 or 2; X, Y and Z, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl (including haloalkyl), optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, (including haloalkoxy), optionally substituted alkylthio, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted acyloxy, optionally substituted amino, optionally substituted acylamino, nitro, cyano, --CO2 R3, --CONR4 R5, --COR6 or --S(O)m R7 (wherein m is 0, 1 or 2) groups, or any two of the groups X, Y and Z, when they are in adjacent positions on the phenyl ring, may join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; R1 and R2, which are the same or different, are optionally substituted alkyl (including fluoroalkyl) groups provided that when W is 5-trifluoromethylpyridin-2-yl, A is oxygen, X is hydrogen, and R1 and R2 are both methyl, Y and Z are not both hydrogen, Y is not F, Cl, methyl, nitro, 5--CF3, 5--SCH3 or 4--(CH3)2 N if Z is hydrogen and Y and Z together are not 3-nitro-5-chloro, 3,5-dinitro, 4,5-dimethoxy or 4,5-methylenedioxy; and R3, R4, R5, R6 and R7, which are the same or different, are hydrogen atoms or optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted aralkyl groups; and metal complexes thereof.