22160-39-0

Basic information

• Product Name: 2-METHYLVALERIC ACID
• Synonyms: RARECHEM AL BE 0135;N-PENTANE-2-CARBOXYLIC ACID;FEMA 2754;FEMA NUMBER 2754;METHYLPROPYLACETIC ACID;2-METHYL-N-PENTANOIC ACID;2-METHYL-N-VALERIC ACID
• CAS NO: 22160-39-0
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.16
• EINECS: 202-594-9
• Mol File: 22160-39-0.mol
• Article Data: 59

Chemical Properties

• Melting Point: -85°C
• Boiling Point: 196-197 °C(lit.)
• Flash Point: 196 °F
• Appearance: /
• Density: 0.931 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.414(lit.)
• CAS DataBase Reference: 2-METHYLVALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLVALERIC ACID(22160-39-0)
• EPA Substance Registry System: 2-METHYLVALERIC ACID(22160-39-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• RTECS: YV7700000
• Hazardous Substances Data: 22160-39-0(Hazardous Substances Data)

Usage

General Description

2-Methylvaleric acid, also known as 3-methylbutanoic acid, is a branched-chain fatty acid with a molecular formula of C6H12O2. It is a clear, colorless liquid with a pungent odor and is used in the production of flavors and fragrances. This chemical can be found naturally in certain fruits and dairy products and is also used in the manufacture of solvents, plasticizers, and pharmaceuticals. Additionally, 2-methylvaleric acid has been studied for its potential in treating various health conditions such as bacterial infections and inflammatory diseases. Overall, it is a versatile chemical with applications in various industries.

Upstream product

• 6641-83-4 2-methyl-4-oxopentanoic acid 
• 110-54-3 hexane 
• 201230-82-2 carbon monoxide 
• 123-15-9 2-methylvaleraldehyde 
• 3142-72-1 2-methyl-2-pentenoic acid 
• 89585-04-6 2-(2-methyl-1-pentyl)-boronic acid 
• 5659-14-3 4-[(Z)-ethylidene]-3-methyloxetan-2-one 
• 78-26-2 2-methyl-2-propyl-1,3-propanediol 
• 469-09-0 2-C-hydroxymethyl-D-ribonic acid 
• 105-30-6 2-methylpentan-1-ol 
• 136750-14-6 2-cyano-2-methylpentanoic acid methyl ester 
• 17265-25-7 sodium 2-methylpentanoate 
• 124-38-9 carbon dioxide 
• 109-66-0 pentane 

Downstream Products

• 1606-47-9 isopropyl vinyl ketone 
• 116908-84-0 2-methylvaleryl chloride 
• 35432-75-8 C₁₀H₂₀O₃ 
• 2533-89-3 N-(3,4-dichlorophenyl)-2-methylpentanamide 
• 2177-77-7 methyl 2-methylpentanoate 
• 63169-61-9 2-methylpentanoyl 2-methylpentanoate 
• 107-87-9 2-Pentanone 
• 6032-29-7 (+/-)-2-pentanol 
• 2170681-06-6 1,3-dioxoisoindolin-2-yl 2-methylpentanoate 

Relevant articles and documents

Aerobic oxidation of aldehydes to acids with N-hydroxyphthalimide derivatives

The N-hydroxyphthalimide derivative-mediated aerobic oxidation of a selection of aldehydes to the corresponding carboxylic acids in air is described. This reaction proceeds via rearrangement of the Creigee (carboxylic peracid) intermediate and/or by the treatment of H2O and/or sulfides. Optimization of reaction conditions established NHNPI (14) as a mild catalyst for the oxidation reaction in MeCN under an atmosphere of air.

Ruthenium-catalysed hydroxycarbonylation of olefins

State-of-the-art catalyst systems for hydroxy- and alkoxycarbonylations of olefins make use of palladium complexes. In this work, we report a complementary ruthenium-catalysed hydroxycarbonylation of olefins applying an inexpensive Ru-precursor (Ru3(CO)12) and PCy3as a ligand. Crucial for the success of this transformation is the use of hexafluoroisopropanol (HFIP) as the solvent in the presence of an acid co-catalyst (PTSA). Overall, moderate to good yields are obtained using aliphatic olefins including the industrially relevant substrate di-isobutene. This atom-efficient catalytic transformation provides straightforward access to various carboxylic acids from unfunctionalized olefins.

Oxidation of aromatic and aliphatic aldehydes to carboxylic acids by Geotrichum candidum aldehyde dehydrogenase

Oxidation reaction is one of the most important and indispensable organic reactions, so that green and sustainable catalysts for oxidation are necessary to be developed. Herein, biocatalytic oxidation of aldehydes was investigated, resulted in the synthesis of both aromatic and aliphatic carboxylic acids using a Geotrichum candidum aldehyde dehydrogenase (GcALDH). Moreover, selective oxidation of dialdehydes to aldehydic acids by GcALDH was also successful.