22307-94-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)(9CI) is used as an intermediate in the synthesis of various pharmaceuticals and related compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)(9CI) serves as a key intermediate for the preparation of a wide range of organic compounds. Its versatility in chemical reactions allows for the synthesis of various target molecules with potential applications in different industries.
Used in Medicinal Chemistry Research:
Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)(9CI) is utilized in medicinal chemistry research for the exploration of its potential pharmacological and biological activities. Its unique structure and functional groups make it an interesting candidate for the development of new therapeutic agents and the study of their mechanisms of action.

Upstream product

• 15150-39-7 2-chloroacetic acid 4-methylphenyl ester 
• 305834-64-4 1-(2-acetoxy-5-methyl-phenyl)-2-chloro-ethanone 
• 104-93-8 p-methylanizole 
• 79-04-9 chloroacetyl chloride 
• 106-44-5 p-cresol 
• 59354-24-4 chloroacetonitrile 
• 7446-70-0 aluminium trichloride 
• 79-11-8 chloroacetic acid 
• 34087-19-9 2-acetyl-4-methylphenyl acetate 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 

Downstream Products

• 128733-90-4 (2-hydroxy-5-methylphenacyl)pyridinium chloride 
• 861549-32-8 2-anilino-1-(2-hydroxy-5-methyl-phenyl)-ethanone 
• 108971-73-9 3-hydroxy-2-(2-methoxy-phenyl)-6-methyl-chromen-4-one 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 54120-66-0 5-methyl-benzofuran-3-one 
• 4022-19-9 4-methoxy-benzoic acid-(2-chloroacetyl-4-methyl-phenyl ester) 
• 95814-29-2 3-acetoxy-2-(3,4-dimethoxy-phenyl)-6-methyl-chromen-4-one 
• 60904-74-7 2-(4-methoxy-benzylidene)-5-methyl-benzofuran-3-one 
• 861528-95-2 N-(2-hydroxy-5-methyl-phenacyl)-benzanilide 
• 128733-93-7 2,6-bis<3-(hydroxymethyl)-2-methoxy-5-methylphenyl>-pyridine N-oxide 
• 108294-03-7 2,6-bis<3-(hydroxymethyl)-2-methoxy-5-methylphenyl>-pyridine 

Relevant academic research and scientific papers

Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis

Death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) is a serine/threonine kinase that plays a key role in a wide variety of cell death signaling pathways. Inhibition of DRAK2 was found to efficiently protect islet β-cells from apoptosis and hence DRAK2 inhibitors represent a promising therapeutic strategy for the treatment of diabetes. Only very few chemical entities targeting DRAK2 are currently known. We carried out a high throughput screening and identified compound 4 as a moderate DRAK2 inhibitor with an IC50value of 3.15?μM. Subsequent SAR studies of hit compound 4 led to the development of novel benzofuran-3(2H)-one series of DRAK2 inhibitors with improved potency and favorable selectivity profiles against 26 selected kinases. Importantly, most potent compounds 40 (IC50?=?0.33?μM) and 41 (IC50?=?0.25?μM) were found to protect islet β-cells from apoptosis in dose-dependent manners. These data support the notion that small molecule inhibitors of DRAK2 represents a promising strategy for the treatment of diabetes.