22307-94-4

Basic information

• Product Name: Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)- (9CI)
• Synonyms: Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)- (9CI)
• CAS NO: 22307-94-4
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.61956
• Product Categories: ACETYLHALIDE
• Mol File: 22307-94-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)- (9CI)(22307-94-4)
• EPA Substance Registry System: Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)- (9CI)(22307-94-4)

Safety Data

• Hazardous Substances Data: 22307-94-4(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-chloro-1-(2-hydroxy-5-methylphenyl)- (9CI) is a chemical compound with the molecular formula C9H9ClO2. It is also known by its systematic name 2-chloro-1-(2-hydroxy-5-methylphenyl)ethanone. This chemical is a derivative of acetophenone and contains a chlorine atom and a hydroxy group attached to a phenyl ring. It is commonly used in organic synthesis and pharmaceutical research, and its properties make it an important intermediate in the production of various pharmaceuticals and related compounds. Additionally, it has been studied for its potential pharmacological and biological activities in medicinal chemistry.

Upstream product

• 15150-39-7 2-chloroacetic acid 4-methylphenyl ester 
• 305834-64-4 1-(2-acetoxy-5-methyl-phenyl)-2-chloro-ethanone 
• 106-44-5 p-cresol 
• 79-11-8 chloroacetic acid 
• 104-93-8 p-methylanizole 
• 79-04-9 chloroacetyl chloride 
• 7446-70-0 aluminium trichloride 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 34087-19-9 2-acetyl-4-methylphenyl acetate 
• 59354-24-4 chloroacetonitrile 

Downstream Products

• 54120-66-0 5-methyl-benzofuran-3-one 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 60904-75-8 (Z)-2-(4-hydroxybenzylidene)-5-methylbenzofuran-3(2H)-one 
• 4022-19-9 4-methoxy-benzoic acid-(2-chloroacetyl-4-methyl-phenyl ester) 
• 861549-32-8 2-anilino-1-(2-hydroxy-5-methyl-phenyl)-ethanone 
• 6971-17-1 3-hydroxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 305834-64-4 1-(2-acetoxy-5-methyl-phenyl)-2-chloro-ethanone 
• 128733-90-4 (2-hydroxy-5-methylphenacyl)pyridinium chloride 
• 861528-95-2 N-(2-hydroxy-5-methyl-phenacyl)-benzanilide 
• 87127-82-0 3-(4-Chloro-benzenesulfonyl)-6-methyl-2-(2-nitro-phenyl)-chromen-4-one 
• 87127-96-6 3-(4-Bromo-benzenesulfonyl)-6-methyl-2-(4-nitro-phenyl)-chromen-4-one 
• 87127-84-2 3-(4-Chloro-benzenesulfonyl)-6-methyl-2-(4-nitro-phenyl)-chromen-4-one 
• 87127-95-5 3-(4-Bromo-benzenesulfonyl)-6-methyl-2-(3-nitro-phenyl)-chromen-4-one 
• 87127-83-1 3-(4-Chloro-benzenesulfonyl)-6-methyl-2-(3-nitro-phenyl)-chromen-4-one 

Relevant articles and documents

Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis

Death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) is a serine/threonine kinase that plays a key role in a wide variety of cell death signaling pathways. Inhibition of DRAK2 was found to efficiently protect islet β-cells from apoptosis and hence DRAK2 inhibitors represent a promising therapeutic strategy for the treatment of diabetes. Only very few chemical entities targeting DRAK2 are currently known. We carried out a high throughput screening and identified compound 4 as a moderate DRAK2 inhibitor with an IC50value of 3.15?μM. Subsequent SAR studies of hit compound 4 led to the development of novel benzofuran-3(2H)-one series of DRAK2 inhibitors with improved potency and favorable selectivity profiles against 26 selected kinases. Importantly, most potent compounds 40 (IC50?=?0.33?μM) and 41 (IC50?=?0.25?μM) were found to protect islet β-cells from apoptosis in dose-dependent manners. These data support the notion that small molecule inhibitors of DRAK2 represents a promising strategy for the treatment of diabetes.

Condensation of phenols with halogenoacids using boron trifluoride

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