34087-19-9

Upstream product

• 78812-97-2 1-(2-acetoxy-5-methylphenyl)vinyl acetate 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 101602-24-8 3,3-dibromo-2-(4-methoxy-phenyl)-6-methyl-chroman-4-one 
• 14221-83-1 (+/-)-3c-bromo-2r-(4-methoxy-phenyl)-6-methyl-chroman-4-one 
• 903556-90-1 2-acetyl-4-(bromomethyl)phenyl acetate 
• 6971-17-1 3-hydroxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 60904-74-7 2-(4-methoxy-benzylidene)-5-methyl-benzofuran-3-one 
• 22307-94-4 2-chloroacetyl-4-methylphenol 
• 16108-51-3 2,6-dimethyl-chromen-4-one 
• 103502-89-2 1-(2-acetoxy-5-methyl-phenyl)-2,2-dibromo-ethanone 
• 305834-64-4 1-(2-acetoxy-5-methyl-phenyl)-2-chloro-ethanone 

Relevant academic research and scientific papers

PEGYLATED CARFILZOMIB COMPOUNDS

The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of

Multicyclic bis-amide MMP inhibitors

The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.

Photolysis of Enol Acetates and α-Bromo Derivatives of o-(Acyloxy)acetophenones

UV irradiation of enol acetates 3a-g in benzene gives mainly o-(acetoxy)acetophenones 2 and 2-methylchromones 4. Under the same conditions, the dimethyl derivatives 3h and 3i remain unaffected.The α-bromo ketone 5a gives rise to mixtures of o-(acetoxy)acetophenone (2a), the diketone 6, and/or α-acetoxy-o-hydroxyacetophenone (7), depending on the irradiation conditions.The similarities and differences between the two series of experiments, as well as their possible mechanistic implications, are discussed.