22446-20-4

Usage

Uses

Used in Chemical Synthesis:
2-Phenylsulfanylacetamide is used as an intermediate in the synthesis of various organic compounds, contributing to the formation of complex molecules through chemical reactions.
Used in Pharmaceutical Research:
2-Phenylsulfanylacetamide is used as a potential candidate in pharmaceutical research for its potential applications in drug development, although this requires further investigation and validation to establish its efficacy and safety.

InChI:InChI=1/C8H9NOS/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

Upstream product

• 108-98-5 thiophenol 
• 79-07-2 Chloroacetamide 
• 5977-14-0 acetoacetamido 
• 7031-27-8 (phenylthio)acetic acid chloride 
• 103-04-8 (phenylthio)acetic acid 
• 930-69-8 sodium thiophenolate 
• 7605-25-6 ethyl phenylsulfenylacetate 

Downstream Products

• 78281-62-6 2-amino-3-(4-chlorobenzoyl)-α-(phenylthio)benzeneacetamide 
• 16503-79-0 α,α-Difluoro-α-(phenylthio)acetamide 
• 220155-44-2 2-fluoro-2-(phenylsulfanyl)acetamide 
• 29261-44-7 4,6-diphenyl-2-pyridone 
• 1600528-05-9 3-[2-(phenylthiomethyl)thiazol-4-yl]-N-hydroxybenzamide 
• 1600528-12-8 3-[2-(phenylthiomethyl)thiazol-4-yl]benzoic acid methyl ester 
• 59865-82-6 2-(phenylthio)ethanethioamide 

Relevant academic research and scientific papers

One-Pot Sequential Multistep Transformation of α,β-Unsaturated Trifluoromethyl Ketones: Facile Synthesis of Trifluoromethylated 2-Pyridones

A one-pot transformation of α,β-unsaturated trifluoromethyl ketones with 2-(phenylsulfinyl)acetamide to give trifluoromethylated 2-pyridones is realized. The reaction proceeds under mild conditions and involves multiple steps in an expeditious and controlled sequence to provide efficient access to a broad range of trifluoromethylated 2-pyridones in moderate to high yields. Moreover, further synthetic manipulations permit the routine synthesis of a diverse array of trifluoromethylated pyridines with good efficiency.

Direct access to α-sulfenylated amides/esters: Via sequential oxidative sulfenylation and C-C bond cleavage of 3-oxobutyric amides/esters

An efficient, environmentally benign and unprecedented synthesis of various α-sulfenylated amides/esters has been developed under oxygen atmosphere. The reaction shows good functional group tolerance and excellent chemo/regioselectivity. All the desired products were obtained in moderate to excellent yields, even on the gram scale. Practically, the related α-thiol Weinreb amide can be readily transferred to a series of prospective compounds, and selenium atom can be introduced to the α-sites of the amides in high yields.

HYDROXAMIC ACID DERIVATIVES AND HDAC8 INHIBITORS

PROBLEM TO BE SOLVED: To provide compounds that are highly active and can highly selectively inhibit HDAC8 functionality, and HDAC8 inhibitors. SOLUTION: Each hydroxamic acid derivative comprise a compound of the general formula (1) in the figure, where φ

Synthesis and biological evaluation of 2-Phenoxyacetamide analogues, a novel class of potent and selective monoamine oxidase inhibitors

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI = 245) and (2-(4-((prop-2- ynylimino)methyl)phenoxy)acetamide (compound 21) (IC50MAO-A = 0.018 μM, IC50MAO-B = 0.07 μM) were successfully identified as the most specific MAO-A inhibitor, and the most potent MAO-A/-B inhibitor, respectively. The inhibitory activities of these two compounds in living cells were also further evaluated utilizing HepG2 and SHSY-5Y cell lysates.

Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylasea 8-selective inhibitors

We recently discovered N-hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol- 4-yl]benzamide (NCC149) as a potent and selective histone deacetylasea 8 (HDAC8) inhibitor from a 151-member triazole compound library using a click chemistry approach. In this wor

2-pyridone synthesis using 2-(phenylsulfinyl)acetamide

2-Pyridones were prepared by means of an efficient protocol including the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination.

Direct catalytic formation of primary and tertiary amides from non-activated carboxylic acids, employing carbamates as amine source

The operationally simple titanium(IV)- or zirconium(IV)-catalyzed direct amidation of non-activated carboxylic acids with ammonium carbamates generates primary, and tertiary N,N-dimethyl-substituted amides in good to excellent yields. Copyright