22446-20-4

Basic information

• Product Name: 2-phenylsulfanylacetamide
• Synonyms: 2-phenylsulfanylacetamide
• CAS NO: 22446-20-4
• Molecular Formula: C₈H₉NOS
• Molecular Weight: 167.23
• Mol File: 22446-20-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 339.6 °C at 760 mmHg
• Flash Point: 159.2 °C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 9.08E-05mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 2-phenylsulfanylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylsulfanylacetamide(22446-20-4)
• EPA Substance Registry System: 2-phenylsulfanylacetamide(22446-20-4)

Safety Data

• Hazardous Substances Data: 22446-20-4(Hazardous Substances Data)

Usage

General Description

2-Phenylsulfanylacetamide is a chemical compound within the category of organosulfur compounds, characterized by the presence of sulfuric atom attached to an organic compound. It is also recognized as an aromatic sulfide due to the phenyl group present. 2-phenylsulfanylacetamide has not been widely studied or used, and no specific applications have been indicated in scientific papers or patents. However, aromatic sulfides including 2-phenylsulfanylacetamide can often be used in the synthesis of other compounds, as well as potential use in pharmaceuticals, although this would require further research and validation. Its chemical formula is C8H9NOS.

InChI:InChI=1/C8H9NOS/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

Upstream product

• 7605-25-6 ethyl phenylsulfenylacetate 
• 108-98-5 thiophenol 
• 79-07-2 Chloroacetamide 
• 930-69-8 sodium thiophenolate 
• 103-04-8 (phenylthio)acetic acid 
• 5977-14-0 acetoacetamido 
• 7031-27-8 (phenylthio)acetic acid chloride 

Downstream Products

• 78281-62-6 2-amino-3-(4-chlorobenzoyl)-α-(phenylthio)benzeneacetamide 
• 49639-34-1 phenylsulfinylacetic acid amide 
• 16503-79-0 α,α-Difluoro-α-(phenylthio)acetamide 
• 220155-44-2 2-fluoro-2-(phenylsulfanyl)acetamide 
• 199535-13-2 4-Acetylamino-3-(carbamoyl-phenylsulfanyl-methyl)-benzoic acid methyl ester 
• 78281-65-9 2-Amino-3-benzoyl-5-chloro-α-(phenylthio)phenylacetamide 
• 29261-44-7 4,6-diphenyl-2-pyridone 
• 1600528-05-9 3-[2-(phenylthiomethyl)thiazol-4-yl]-N-hydroxybenzamide 
• 1600528-12-8 3-[2-(phenylthiomethyl)thiazol-4-yl]benzoic acid methyl ester 
• 59865-82-6 2-(phenylthio)ethanethioamide 

Relevant articles and documents

One-Pot Sequential Multistep Transformation of α,β-Unsaturated Trifluoromethyl Ketones: Facile Synthesis of Trifluoromethylated 2-Pyridones

A one-pot transformation of α,β-unsaturated trifluoromethyl ketones with 2-(phenylsulfinyl)acetamide to give trifluoromethylated 2-pyridones is realized. The reaction proceeds under mild conditions and involves multiple steps in an expeditious and controlled sequence to provide efficient access to a broad range of trifluoromethylated 2-pyridones in moderate to high yields. Moreover, further synthetic manipulations permit the routine synthesis of a diverse array of trifluoromethylated pyridines with good efficiency.

HYDROXAMIC ACID DERIVATIVES AND HDAC8 INHIBITORS

PROBLEM TO BE SOLVED: To provide compounds that are highly active and can highly selectively inhibit HDAC8 functionality, and HDAC8 inhibitors. SOLUTION: Each hydroxamic acid derivative comprise a compound of the general formula (1) in the figure, where φ

Erratum: 2-pyridone synthesis using 2-(Phenylsulfinyl)acetamide (Org. Lett. (2013) 15: 1 (232-234) DOI: 10.1021/ol303320c)

-