22510-33-4

Basic information

• Product Name: 4'-FLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
• Synonyms: AKOS BAR-0030;4'-FLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID;4'-FLUORO-4-HYDROXY[1,1'-BIPHENYL]-3-CARBOXYLIC ACID;5-(4-Fluorophenyl)-2-hydroxybenzoic acid, 5-(4-Fluorophenyl)salicylic acid, 2-Carboxy-4-(4-fluorophenyl)phenol
• CAS NO: 22510-33-4
• Molecular Formula: C₁₃H₉FO₃
• Molecular Weight: 232.21
• Mol File: 22510-33-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-FLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID(22510-33-4)
• EPA Substance Registry System: 4'-FLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID(22510-33-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 22510-33-4(Hazardous Substances Data)

Usage

General Description

" 4'-Fluoro-4-hydroxy-biphenyl-3-carboxylic acid is a chemical compound with the molecular formula C13H9FO3. It is a derivative of biphenyl and contains a fluorine and a hydroxyl group attached to the benzene rings. 4'-FLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID is often used in research and pharmaceutical development as a building block for the synthesis of various biologically active molecules. It may also have potential applications in the field of materials science and organic chemistry due to its unique structure and reactivity. Additionally, its properties and potential uses make it an interesting target for further study and investigation in various scientific disciplines.

Upstream product

• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 64465-74-3 4'-fluoro-4-methoxy-biphenyl-3-carboxylic acid methyl ester 
• 119-30-2 2-hydroxy-5-iodobenzoic acid 
• 22494-42-4 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid 
• 22510-35-6 methyl 4’-fluoro-4-hydroxy-[1,1’-biphenyl]-3-carboxylate 
• 89-55-4 5-bromosalicyclic acid 
• 352-13-6 4-flourophenylmagnesium bromide 
• 1765-93-1 4-fluoroboronic acid 
• 2263-65-2 3-carboxy-4-hydroxybenzenediazonium tetrafluoroborate 
• 40757-09-3 methyl 2-methoxy-5-iodobenzoate 
• 4068-75-1 methyl 5-iodosalicylate 

Downstream Products

• 22494-27-5 FLUFENISAL 
• 22494-35-5 4'-fluoro-3-methyl-[1,1'-biphenyl]-4-ol 

Relevant articles and documents

Photochemical outcome modification of diflunisal by a novel cationic amphiphilic cyclodextrin

The effects of a novel cationic amphiphilic cyclodextrin (SC6CDNH2) on the photoprocesses of the phototoxic non-steroidal anti-inflammatory drug diflunisal (DF) have been investigated in aqueous medium. Association between DF and SC6CDNH2 was indicated by steady-state absorption, induced circular dichroism and fluorescence spectroscopy. Laser flash photolysis and steady-state photolysis experiments revealed a particular sensitivity of the DF photochemistry to the new microenvironment. Reduction of the triplet state generation efficiency, lengthening of its lifetime, changes in the photoionisation pathways, besides remarkable drug photostabilization and modification of the stable photoproducts distribution, were observed. A rationale for these modifications to the photochemistry of DF based on the multifaceted role of SC6CDNH2 in influencing the efficiency of the primary photochemical act and in interfering with secondary radical reactions is proposed. Relation of the overall results to the phototoxic effects displayed by the drug is also commented upon.

Green synthesis of biphenyl carboxylic acids via Suzuki–Miyaura cross-coupling catalyzed by a water-soluble fullerene-supported PdCl2 nanocatalyst

A green synthesis of variously substituted biphenyl carboxylic acids was achieved through Suzuki–Miyaura cross-coupling of a bromobenzoic acid with an aryl boronic acid using a water-soluble fullerene-supported PdCl2 nanocatalyst (C60-TEGs/ PdCl2). Yields of more than 90% were obtained at room temperature in 4 h using 0.05 mol% catalyst and 2 equiv. K2CO3.

A highly efficient catalyst of a nitrogen-based ligand for the Suzuki coupling reaction at room temperature under air in neat water

Glycine, as a kind of commercially available and inexpensive ligand, is used to prepare an air-stable and water-soluble catalyst for the Suzuki-Miyaura reaction in our study. In the presence of 0.1% [PdCl2(NH 2CH2COOH)2] as the catalyst, extremely excellent catalytic activity towards the Suzuki-Miyaura coupling of aryl halides containing the carboxyl group with various aryl boronic acids is observed at room temperature under air in neat water. the Partner Organisations 2014.