22534-71-0

Basic information

• Product Name: N-acetylbutanamide
• CAS NO: 22534-71-0
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.157
• Mol File: 22534-71-0.mol

Chemical Properties

• Boiling Point: 231.7°C at 760 mmHg
• Flash Point: 105.5°C
• Density: 0.988g/cm³
• Vapor Pressure: 0.0614mmHg at 25°C
• Refractive Index: 1.426
• CAS DataBase Reference: N-acetylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetylbutanamide(22534-71-0)
• EPA Substance Registry System: N-acetylbutanamide(22534-71-0)

Safety Data

• Hazardous Substances Data: 22534-71-0(Hazardous Substances Data)

Upstream product

• 541-35-5 butanamide 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 1119-49-9 N-butylacetamide 
• 106-31-0 butanoic acid anhydride 
• 75-05-8 acetonitrile 
• 109-74-0 propyl cyanide 
• 109-90-0 ethyl isocyanate 

Downstream Products

• 60-35-5 acetamide 
• 541-35-5 butanamide 
• 623-42-7 butanoic acid methyl ester 
• 625-77-4 N-acetylacetamide 
• 105-54-4 butanoic acid ethyl ester 
• 638-11-9 isopropyl butyrate 
• 141-78-6 ethyl acetate 
• 79-20-9 acetic acid methyl ester 

Relevant articles and documents

N-Butylammonium carboxylates/Tf2O: Ionic liquid based systems for the synthesis of unsymmetrical imides via a Ritter-type reaction

We have developed a new method for the preparation of unsymmetrical imides using liquid carboxylate salts via a Ritter-type process. The reactions were carried out with nitriles and n-butylammonium carboxylates as ionic liquids in the presence of triflic anhydride (Tf2O) as the promoter. Mild reaction conditions, simplicity of the procedure, and proton-free conditions are the main advantages of this procedure.

Ultrasound-assisted catalytic synthesis of acyclic imides in the presence of p-toluenesulfonic acid under solvent-free conditions

A rapid and convenient preparation of acyclic imides by the reaction of aliphatic and aromatic nitriles with acyclic carboxylic anhydride in the presence of catalytic amounts of p-toluenesulfonic acid under thermal or ultrasonic conditions is reported. The advantages of this procedure are moderate reaction times, good to excellent yields, and use of an inexpensive and ecofriendly catalyst. The reaction of nitriles with aliphatic anhydrides proceeds under thermal conditions, while they are accelerated by the use of ultrasound irradiation.

Efficient synthesis of symmetrical and unsymmetrical acyclic imides catalyzed by reusable 12-tungstophosphoric acid under thermal conditions and microwave irradiation

An efficient and environmentally friendly procedure has been developed for the synthesis of symmetrical and unsymmetrical acyclic imides by the reaction of nitriles with acyclic anhydrides in the presence of catalytic amounts of 12-tungstophosphoric acid (H3PW12O40) under thermal conditions and microwave irradiation. It was found that microwave improves the yields and significantly reduces the reaction times. Furthermore, the catalyst could be recovered and reused several times without decrease in its activity.

A novel one-pot synthesis of unsymmetrical acyclic imides

A new and convenient method was found for the one-pot synthesis of symmetrical and unsymmetrical linear imides by reaction of aliphatic and aromatic nitriles with acyclic carboxylic anhydrides in the presence of silica sulfuric acid as an active and recyclable reagent. Georg Thieme Verlag Stuttgart.

A bromine-catalysed free-radical oxidation of acetamides from primary and secondary alkylamines by H2O2

New procedures based on the oxidation by bromine-catalysed hydrogen peroxide in a two-phase system provide simple and cheap transformations of alkylamines to carbonyl derivatives (aldehydes, ketones, carboxylic acid, imides, lactams) through the corresponding acetamides.