22680-62-2

Upstream product

• 16619-14-0 2-phenyl-2,3-dihydro-1H-quinolin-4-one 
• 149-73-5 trimethyl orthoformate 
• 14547-98-9 4-methoxyquinoline-N-oxide 
• 591-51-5 phenyllithium 
• 67-56-1 methanol 
• 16714-25-3 2-azidobenzaldehyde 
• 536-74-3 phenylacetylene 
• 88034-35-9 pentacarbonyl{1-(1-methoxy-3(E)-phenyl-2-propenylidene)}chromium⁽⁰⁾ 
• 615-43-0 2-iodophenylamine 
• 100-52-7 benzaldehyde 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 551-93-9 2-aminoacetophenone 
• 53256-22-7 ethyl β-anilinocinnamate 
• 78396-00-6 2-aminochalcone 

Downstream Products

• 109734-46-5 4-methoxy-1-methyl-2-phenyl-quinolinium; iodide 
• 17182-60-4 N-methyl-2-phenylquinolin-4(1H)-one 

Relevant academic research and scientific papers

A novel one-pot oxidative cyclization of 2′-amino and 2′-hydroxychalcones employing FeCl3·6H2O-methanol. Synthesis of 4-alkoxy-2-aryl-quinolines and flavones

A simple, inexpensive, and efficient oxidative cyclization of 2′-amino and 2′-hydroxychalcones has been carried out by employing FeCl3·6H2O-methanol under mild conditions. This method has been investigated for the synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)-4-methoxyquinolines.

Iodine-methanol-promoted oxidation of 2-aryl-1,2,3,4-tetrahydro-4- quinolones to 2-aryl-4-methoxyquinolinest

2-Aryl-1,2,3,4-tetrahydro-4-quinolones are converted in high yields to the corresponding 2-aryl-4-methoxyquinolines using molecular iodine in refluxing methanol; the structures of the quinoline derivatives are determined using 1H and 13C NMR spectroscopic techniques.

Hypervalent iodine oxidation of 2-aryl-1,2,3,4-tetrahydro-4-quinolones: An expedient route to naturally occurring 4-alkoxy-2-arylquinolines

Easily accessible 2-aryl-1,2,3,4-tetrahydro-4-quinolones are readily oxidized to the corresponding 4-alkoxy-2-arylquinolines using a relatively safe hypervalent iodine reagent, [hydroxy (tosyloxy)iodo]benzene (HTIB), in high yields, thus providing a conci

Palladium-Catalyzed [3+3] Annulation of Vinyl Chromium(0) Carbene Complexes through Carbene Migratory Insertion/Tsuji–Trost Reaction

Vinyl chromium(0) Fischer carbene complexes were employed as the source of π-allylic palladium species for catalytic [3+3] annulation under palladium catalysis. Mechanistically, this transformation is proposed to involve carbene migratory insertion and intramolecular Tsuji–Trost reaction as the key steps. Substituted six-membered heterocyclic flavonones and quinolines are obtained, depending on the nucleophilic functional group on the coupling partners.

Lewis Acid Promoted Oxonium Ion Driven Carboamination of Alkynes for the Synthesis of 4-Alkoxy Quinolines

Lewis acid mediated multisegment coupling cascade is designed for the synthesis of densely substituted 4-alkoxy quinolines via an oxonium ion triggered alkyne carboamination sequence involving C-C and C-N bond formations. Cyclic ether fused-quinolines cou

POLYPHENOL ANALOGS TO TREAT ISCHEMIA

The present invention provides methods of use of polyphenol compounds for treating, preventing, mitigating and delaying ischemia or a condition where ischemia occurs. In one embodiment, the method comprises providing a polyphenol analog; and administering

NEUROPROTECTIVE POLYPHENOL ANALOGS

The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neur

Chemical modification of the multitarget neuroprotective compound fisetin

Many factors are implicated in age-related central nervous system (CNS) disorders, making it unlikely that modulating only a single factor will provide effective treatment. Perhaps a better approach is to identify small molecules that have multiple biolog

Sulfuric acid promoted condensation cyclization of 2-(2-(trimethylsilyl) ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient one-pot synthesis of 4-alkoxy-2-arylquinolines

An efficient method for the synthesis of 4-alkoxy-2-arylquinolines has been developed. The reaction proceeds smoothly by heating a mixture of easily accessible 2-(2-(trimethylsilyl) ethynyl)anilines and arylaldehydes in alcoholic solvents in the presence of sulfuric acid.

Thallium(III) nitrate mediated ring contraction of 2-aryl-1,2,3,4- tetrahydro-4-quinolones: Stereoselective synthesis of trans methyl 2-aryl-2,3-dihydroindol-3-carboxylates

The ring contraction of N-acetyl-2-aryl-1,2,3,4-tetrahydro-4-quinolones 1a-d with thallium(III) nitrate in trimethyl orthoformate afforded stereoselectively trans methyl N-acetyl-2-aryl-2,3-dihydroindol-3-carboxylates 5a-d by oxidative rearrangement of ar