22680-62-2

Upstream product

• 4979-79-7 4-chloro-2-phenylquinoline 
• 124-41-4 sodium methylate 
• 14547-98-9 4-methoxyquinoline-N-oxide 
• 14802-18-7 2-phenyl-1H-quinolin-4-one 
• 74-88-4 methyl iodide 
• 1144-20-3 2-phenyl-4-quinolinol 
• 16619-14-0 2-phenyl-2,3-dihydro-1H-quinolin-4-one 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 
• 591-51-5 phenyllithium 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 60355-81-9 1-N-acetyl-4-keto-2-phenyl-1,2,3,4-tetrahydroquinoline 
• 551-93-9 2-aminoacetophenone 

Downstream Products

• 109734-46-5 4-methoxy-1-methyl-2-phenyl-quinolinium; iodide 
• 17182-60-4 N-methyl-2-phenylquinolin-4(1H)-one 

Relevant academic research and scientific papers

A novel one-pot oxidative cyclization of 2′-amino and 2′-hydroxychalcones employing FeCl3·6H2O-methanol. Synthesis of 4-alkoxy-2-aryl-quinolines and flavones

A simple, inexpensive, and efficient oxidative cyclization of 2′-amino and 2′-hydroxychalcones has been carried out by employing FeCl3·6H2O-methanol under mild conditions. This method has been investigated for the synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)-4-methoxyquinolines.

Iodine-methanol-promoted oxidation of 2-aryl-1,2,3,4-tetrahydro-4- quinolones to 2-aryl-4-methoxyquinolinest

2-Aryl-1,2,3,4-tetrahydro-4-quinolones are converted in high yields to the corresponding 2-aryl-4-methoxyquinolines using molecular iodine in refluxing methanol; the structures of the quinoline derivatives are determined using 1H and 13C NMR spectroscopic techniques.

Hypervalent iodine oxidation of 2-aryl-1,2,3,4-tetrahydro-4-quinolones: An expedient route to naturally occurring 4-alkoxy-2-arylquinolines

Easily accessible 2-aryl-1,2,3,4-tetrahydro-4-quinolones are readily oxidized to the corresponding 4-alkoxy-2-arylquinolines using a relatively safe hypervalent iodine reagent, [hydroxy (tosyloxy)iodo]benzene (HTIB), in high yields, thus providing a conci

Lewis Acid Promoted Oxonium Ion Driven Carboamination of Alkynes for the Synthesis of 4-Alkoxy Quinolines

Lewis acid mediated multisegment coupling cascade is designed for the synthesis of densely substituted 4-alkoxy quinolines via an oxonium ion triggered alkyne carboamination sequence involving C-C and C-N bond formations. Cyclic ether fused-quinolines cou

Palladium-Catalyzed [3+3] Annulation of Vinyl Chromium(0) Carbene Complexes through Carbene Migratory Insertion/Tsuji–Trost Reaction

Vinyl chromium(0) Fischer carbene complexes were employed as the source of π-allylic palladium species for catalytic [3+3] annulation under palladium catalysis. Mechanistically, this transformation is proposed to involve carbene migratory insertion and intramolecular Tsuji–Trost reaction as the key steps. Substituted six-membered heterocyclic flavonones and quinolines are obtained, depending on the nucleophilic functional group on the coupling partners.

POLYPHENOL ANALOGS TO TREAT ISCHEMIA

The present invention provides methods of use of polyphenol compounds for treating, preventing, mitigating and delaying ischemia or a condition where ischemia occurs. In one embodiment, the method comprises providing a polyphenol analog; and administering

NEUROPROTECTIVE POLYPHENOL ANALOGS

The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neur

Chemical modification of the multitarget neuroprotective compound fisetin

Many factors are implicated in age-related central nervous system (CNS) disorders, making it unlikely that modulating only a single factor will provide effective treatment. Perhaps a better approach is to identify small molecules that have multiple biolog

Sulfuric acid promoted condensation cyclization of 2-(2-(trimethylsilyl) ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient one-pot synthesis of 4-alkoxy-2-arylquinolines

An efficient method for the synthesis of 4-alkoxy-2-arylquinolines has been developed. The reaction proceeds smoothly by heating a mixture of easily accessible 2-(2-(trimethylsilyl) ethynyl)anilines and arylaldehydes in alcoholic solvents in the presence of sulfuric acid.

Thallium(III) nitrate mediated ring contraction of 2-aryl-1,2,3,4- tetrahydro-4-quinolones: Stereoselective synthesis of trans methyl 2-aryl-2,3-dihydroindol-3-carboxylates

The ring contraction of N-acetyl-2-aryl-1,2,3,4-tetrahydro-4-quinolones 1a-d with thallium(III) nitrate in trimethyl orthoformate afforded stereoselectively trans methyl N-acetyl-2-aryl-2,3-dihydroindol-3-carboxylates 5a-d by oxidative rearrangement of ar