17182-60-4Relevant academic research and scientific papers
An Efficient Synthesis of (1-Methyl)-2-phenyl-4-quinolones from (N-Methyl)isatoic Anhydride
In Lee, Jae
, p. 556 - 558 (2021/02/09)
The acyl substitution of (N-methyl)isatoic anhydride with N,O-dimethylhydroxylamine hydrochloride in CH3CN gave N-methoxy-N-methyl 2-(N-methyl)aminobenzamide, which was treated with ethynyllithium reagents to afford 1-[2-(N-methyl)amino]-3-phen
Direct Synthesis of 4-Quinolones via Copper-Catalyzed Anilines and Alkynes
Xu, Xuefeng,Zhang, Xu
supporting information, p. 4984 - 4987 (2017/09/22)
A unique and direct approach for constructing 4-quinolones from simple and readily available anilines and alkynes is described. Under the optimal conditions, both N-alkyl- and N-aryl-substituted anilines can be successfully transformed into the corresponding 4-quinolones. This reaction is characterized by mild reaction conditions, high functional-group tolerance, and amenability to gram-scale synthesis.
Transition-metal-free solid phase synthesis of 1,2-disubstituted 4-quinolones via the regiospecific synthesis of enaminones
Vinayaka, Ajjampura C.,Swaroop, Toreshettahally R.,Chikkade, Prasanna Kumara,Rangappa, Kanchugarakoppal S.,Sadashiva, Maralinganadoddi P.
, p. 11528 - 11535 (2016/02/09)
Herein, the transition-metal-free economical solid phase synthesis of 1,2-disubstituted 4-quinolones has been developed via the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized via a silica-supported solid-
Direct synthesis of 2-aryl-4-quinolones via transition-metal-free intramolecular oxidative C(sp3)-H/C(sp3)-H coupling
Hu, Wei,Lin, Jian-Ping,Song, Li-Rui,Long, Ya-Qiu
supporting information, p. 1268 - 1271 (2015/05/20)
A novel, metal-free oxidative intramolecular Mannich reaction was developed between secondary amines and unmodified ketones, affording a simple and direct access to a broad range of 2-arylquinolin-4(1H)-ones through C(sp3)-H activation/C(sp3)-C(sp3) bond formation from readily available N-arylmethyl-2-aminophenylketones, using TEMPO as the oxidant and KOtBu as the base.
Preparation method of 1-alkyl-2-phenyl-4-quinolones
-
, (2016/10/17)
Provided is a novel method for synthesizing 1-alkyl-2-phenyl-4-quinolones from 2-halobenzoates. The synthesizing method in the present invention has advantages capable of synthesizing 1-alkyl-2-phenyl-4-quinolones in high yield through a simplified stage in a simple reaction condition by means of 2-halobenzoates as an inexpensive starting material.COPYRIGHT KIPO 2015
Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One-Pot Synthesis of Flavones
Yatabe, Takafumi,Jin, Xiongjie,Yamaguchi, Kazuya,Mizuno, Noritaka
supporting information, p. 13302 - 13306 (2015/11/09)
Flavones are a class of natural products with diverse biological activities and have frequently been synthesized by step-by-step procedures using stoichiometric amounts of reagents. Herein, a catalytic one-pot procedure for the synthesis of flavone and its derivatives is developed. In the presence of gold nanoparticles supported on a Mg-Al layered double hydroxide (Au/LDH), various kinds of flavones can be synthesized starting from 2′-hydroxyacetophenones and benzaldehydes (or benzyl alcohols). The present one-pot procedure consists of a sequence of several reactions, and Au/LDH can catalyze all these different types of reactions. The catalysis is shown to be truly heterogeneous, and Au/LDH can be readily recovered and reused. Go for gold: In the presence of gold nanoparticles supported on a Mg-Al layered double hydroxide (Au/LDH), various flavones were obtained from the corresponding 2′-hydroxyacetophenones and benzaldehydes (or benzyl alcohols). All three (four) steps of this one-pot process are catalyzed by Au/LDH in a truly heterogeneous fashion.
Synthesis and cyclisation studies of (E)-2-aryl-1-methyl-3-styrylquinolin-4(1H)-ones
Rocha, Djenisa H.A.,Pinto, Diana C.G.A.,Silva, Artur M.S.
supporting information, p. 7717 - 7721 (2015/09/07)
The synthesis of (E)-2-aryl-1-methyl-3-styrylquinolin-4(1H)-ones, through the Heck reaction of 2-aryl-3-iodo-1-methyl-quinolin-4(1H)-ones with styrene is described. 2-Aryl-3-iodo-1-methyl-2-quinolin-4(1H)-ones can be obtained efficiently in a two-step tra
ZnCl2-catalyzed intramolecular cyclization reaction of 2-aminochalcones using polymer-supported selenium reagent: Synthesis of 2-phenyl-4-quinolones and 2-phenyl-2,3-dihydroquinolin-4(1 H)-one
Tang,Chen, Bangzheng,Zhang, Lianpeng,Li, Wen,Lin, Jun
experimental part, p. 707 - 711 (2011/04/26)
A new and efficient method for the synthesis of 2-phenyl-4-quinolones and 2-phenyl-2,3-dihydroquinolin-4(1H)-ones is described. The reaction involves ZnCl2-mediated polystyrene-supported selenium-induced intramolecular cyclization of 2-amino-chalcones and subsequent traceless or functionalizing cleavage of selenium linker. Georg Thieme Verlag Stuttgart - New York.
Heterocyclic analogs of thioflavones: Synthesis and NMR spectroscopic investigations
Fuchs, Ferdinand C.,Eller, Gernot A.,Holzer, Wolfgang
experimental part, p. 3814 - 3832 (2010/03/03)
The synthesis of several hitherto unknown heterocyclic ring systems derived from thioflavone is described. Coupling of various o haloheteroarenecarbonyl chlorides with phenylacetylene gives 1-(o-haloheteroaryl)-3-phenylprop-2-yn-1- ones, which were treate
