22686-81-3

Basic information

• Product Name: 3-methyl-2-phenylquinazolin-4(3H)-one
• CAS NO: 22686-81-3
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.2686
• Mol File: 22686-81-3.mol
• Article Data: 65

Chemical Properties

• Boiling Point: 396.2°C at 760 mmHg
• Flash Point: 193.4°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.74E-06mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 3-methyl-2-phenylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-phenylquinazolin-4(3H)-one(22686-81-3)
• EPA Substance Registry System: 3-methyl-2-phenylquinazolin-4(3H)-one(22686-81-3)

Safety Data

• Hazardous Substances Data: 22686-81-3(Hazardous Substances Data)

Upstream product

• 76893-90-8 (N-methyl)(phenyl)carbonitrilium trifluoromethylsulfonate 
• 28144-70-9 anthranilic acid amide 
• 16285-32-8 2,3-dihydro-3-methyl-2-phenylquinazolin-4(1H)-one 
• 593-51-1 methylamine hydrochloride 
• 7510-49-8 methyl 2-(benzamido)benzoate 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 58084-22-3 2-iodo-N-methyl-benzamide 
• 618-39-3 benzamidin 
• 100-51-6 benzyl alcohol 
• 3400-29-1 N-methyl-2-nitrobenzamide 
• 118-48-9 isatoic anhydride 
• 100-52-7 benzaldehyde 
• 74-89-5 methylamine 
• 119072-55-8 tert-butylisonitrile 

Downstream Products

• 7031-95-0 1-benzoxy-2,2,6,6-tetramethylpiperidine 
• 52458-01-2 4,4-di-naphthalen-1-yl-2-phenyl-4H-benzo[d][1,3]oxazine 

Relevant articles and documents

Access to 2-Arylquinazolin-4(3H)-ones through Intramolecular Oxidative C(sp3)?H/N?H Cross-Coupling Mediated by I2/DMSO

A novel approach for the synthesis of 2-arylquinazolin-4(3H)-ones was developed. A series of title compounds were obtained with good functional group tolerance and good yields by I2/DMSO-mediated intramolecular oxidative cross-coupling of 2-(benzylamino)benzamides to form C=N double bonds. This method was applicable for gram-scale synthesis. A proposed reaction pathway based on some control experiments was also provided.

An efficient transition-metal-free route to quinazolin-4(3H)-onesvia2-aminobenzamides and thiols

An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction ofo-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step.

Metal-free catalyst for the visible-light-induced photocatalytic synthesis of quinazolinones

In the present work, we have developed a novel and environmentally friendly method for the synthesis of quinazolinones using fluorescein as a photocatalyst via a condensation reaction of o-aminobenzamides and aldehydes under visible light irradiation. In this protocol, neither toxic oxidants nor transition-metal catalysts were needed, and a series of quinazolinones could be obtained in high efficiencies. In addition, this reaction can be extended to gram levels and has a large potential of wide application in future industrialization.