22692-70-2

Upstream product

• 74-96-4 ethyl bromide 
• 98-07-7 Benzotrichlorid 
• 917481-53-9 1-phenylpropyl 3,5-bis(trifluoromethyl)phenyl sulfone 
• 100-52-7 benzaldehyde 
• 103-65-1 phenylpropane 
• 6921-34-2 benzylmagnesium chloride 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 93-55-0 1-phenyl-propan-1-one 
• 74-85-1 ethene 
• 501-65-5 diphenyl acetylene 
• 65-85-0 benzoic acid 
• 667458-78-8 benzyl 3,5-bis(trifluoromethyl)phenyl sulfone 
• 100-39-0 benzyl bromide 
• 863560-55-8 [3,5-bis(trifluoromethyl)phenyl] benzyl sulfide 

Downstream Products

• 16939-12-1 2,3-diphenylthiophene 
• 5223-59-6 1,2-diphenylbutane 
• 100-52-7 benzaldehyde 
• 93-55-0 1-phenyl-propan-1-one 

Relevant academic research and scientific papers

ARYL ISONITRILES AS A NEW CLASS OF ANTIMICROBIAL COMPOUNDS

The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.

Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) have emerged as a global health concern. A new class of compounds featuring an aryl isonitrile moiety has been discovered that exhibits potent inhibitory activity against several clinically-relevant MRSA and VRSA isolates. Structure-activity relationship studies have been conducted to identify the aryl isonitrile group as the key functional group responsible for the observed antibacterial activity. The most potent antibacterial aryl isonitrile analogs (MIC 2 μM) did not show any toxicity against mammalian cells up to a concentration of 64 μM.

SnCl4-Zn: A novel reductive system for deoxygenative coupling of aliphatic, aromatic, chalcone epoxide, and indanone carbonyl compounds to olefins

SnCl4-Zn complex provided a novel reductive system in the deoxygenative cross-coupling of aliphatic, aromatic, chalcone epoxide and indanone carbonyl compounds to olefins in high yield (55-86%) at reflux temperature in THF. The advantage of this reagent is inexpensive, short reaction time, and high yield compared to the reagents used in the McMurry cross-coupling reaction.

Joint cycloalumination of ethylene and other unsaturated compounds with EtAlCl2 in the presence of Cp2ZrCl2. Synthesis of aluminacarbocycles

A procedure has been developed for the selective synthesis of five-membered aluminum-containing heterocycles, 2,3-dialkyl-1-ethylaluminacyclopent-2-enes, 3-alkyl-1-ethylaluminacyclopentanes, 2-alkylidene-1-ethylaluminacyclopentanes, and 3-alkyl-1-ethyl-2-methylidenealuminacyclopentanes, via joint cycloalumination of ethylene and other unsaturated compounds (acetylenes, olefins, and allenes) with EtAlCl2 in the presence of Cp 2ZrCl2 as catalyst.

3,5-Bis(trifluoromethyl)phenyl sulfones in the Julia-Kocienski olefination - Application to the synthesis of tri- and tetrasubstituted olefins

3,5-Bis(trifluoromethyl)phenyl (BTFP) sulfones 8a-d are successfully employed in the modified Julia olefination reaction with carbonyl compounds employing phosphazene base P4-tBu at room temp. in THF, affording tri- and tetrasubstituted olefins in good yi

Regioselective Metallation of Propylbenzene with Superbase: A Convenient Route to Stilbene Derivatives

The benzylic metallation of propylbenzene has been elaborated with LIC-KOR superbase; the method has been applied in a new synthesis of stilbene derivatives.

Formation and Reactivity of ?-Radical Cation Intermediates in the C-C Coupling Reaction of Phenyldiazomethanes by One-Electron Oxidation

One-electron oxidation of phenyldiazomethanes afforded cis-stilbene predominantly.The reaction was independent of the oxidation methods, e.g., electrolysis, copper(II), triarylaminium salts, or photosensitized one-electron oxidtions.The C-C coupling reaction was retarded by introducing α-substituents on phenyldiazomethanes.The ESR spectra of diazoalkane radical cations could be obtained during the electrolysis at low temperature and the resulting spectra revealed their unique electronic structure as ?-radicals for most cases.When a bulky tert-butyl group was substituted, the corresponding ?-radical cation was observed, but the C-C coupling reaction did not occur.The novel HOMO-LUMO switching by one-electron removal from the HOMO ?-orbital of diazomethane is explained by the interaction of phenyl group with the C-N-N ?-radical moiety.The C-C coupling reaction proceeds via facile cycloaddition between the diazomethane and ?-radical cation, and the preferential formation of cis-olefins is based on the secondary orbital interaction between the two phenyl groups.The structure and the stability of radical cation intermediates are rationalized on the basis of ab initio calculations.

The reaction of benzotrihalides and benzal halides with magnesium. Synthetic and mechanistic studies

The benzotrihalides (PhCX3) where X = Cl, Br, and F were allowed to react with magnesium in THF at room temperature.When the halide was chloride or bromide, the trihalide gave diphenylacetylene in high yield in addition to several minor products which were identified.No reaction was observed when the halide was fluoride.When the corresponding dichloride was allowed to react with magnesium in THF, stilbene was formed as the major product.The possible mechanisms for these reactions are discussed.

Diazomethane Radical Cations as a Dipolarophile in the Dimeric Olefin Formation from Diazo-compounds

A novel cycloaddition mechanism involving diazomethane radical cations is proposed for the dimeric olefin formation by the one-electron oxidation of the diazo-compounds.The preference of cis-stilbene formation from phenyldiazomethane is understood by a secondary orbital interaction of phenyl groups on the cycloaddition step.