2274-01-3Relevant academic research and scientific papers
PHOTOCHEMICAL RING OPENING OF BARBITAL
Barton, Henryk,Bojarski, Jacek,Mokrosz, Jerzy
, p. 2133 - 2134 (2007/10/02)
Photolysis of barbital yields derivatives of urea and biuret.The mechanism of ring opening involves an isocyanate intermediate.
Metabolism of bromocarbamides. I. In vitro degradation of carbromal and acetylcarbromal in rabbit liver
Sticht,Kaferstein
, p. 1021 - 1023 (2007/10/12)
10,000 g supernatant of rabbit liver homogenate catalyzes the deacetylation of acetylcarbromal to carbromal. Cis 2 ethyl crotonylurea was proved to be the in vitro debromination product. Trans 2 ethyl crotonylurea and 2 ethyl butyrylurea could be excluded to be primary metabolites of carbromal in this enzyme preparation by comparison of melting points and spectroscopic properties. N Acetyl 2 ethyl crotonylurea, a primary debromation product of acetylcarbromal, could not be detected.
