22945-62-6

Upstream product

• 26838-86-8 pyridine-2-carboxylic acid phenyl ester 
• 1121-60-4 pyridine-2-carbaldehyde 
• 108-95-2 phenol 
• 98-98-6 2-Picolinic acid 
• 29745-44-6 pyridine-2-carbonyl chloride 
• 109-04-6 2-bromo-pyridine 
• 90-02-8 salicylaldehyde 
• 578-57-4 2-bromoanisole 
• 100-70-9 2-Cyanopyridine 
• 22945-63-7 (2-Methoxyphenyl)(pyridine-2-yl)methanone 
• 832-81-5 3-phenyl-[1,2,3]triazolo[1,5-a]pyridine 
• 141580-71-4 2-(pyridin-2-yloxy)benzaldehyde 

Downstream Products

• 845266-66-2 2-[imino(pyridin-2-yl)methyl]phenol 
• 1182372-41-3 C₂₀H₁₈N₂O 
• 1182372-37-7 2-[(isopropylimino)(pyridin-2-yl)methyl]phenol 
• 1182372-34-4 2-[(methylimino)(pyridin-2-yl)methyl]phenol 
• 1182372-40-2 2-[(benzylimino)(pyridin-2-yl)methyl]phenol 
• 1252207-31-0 2-(2-acetoxybenzoyl)pyridine 
• 27827-63-0 6-pyridin-2-yl-3,4-dihydro-2H-benzo[b][1,5]oxazocin-3-ol 

Relevant academic research and scientific papers

A Janus Chelator Enables Biochemically Responsive MRI Contrast with Exceptional Dynamic Range

We introduce a new biochemically responsive Mn-based MRI contrast agent that provides a 9-fold change in relaxivity via switching between the Mn3+ and Mn2+ oxidation states. Interchange between oxidation states is promoted by a “Janu

Compounds for and methods of treating diseases

The present invention provides heterocyclic compounds of formula (I) that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to compounds that modulate iron and to compounds for the treatment of diseases, particularly neurological diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Alzheimer-type dementia, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and multiple system atrophy (MSA).

COMPOUNDS FOR AND METHODS OF TREATING DISEASES

The present invention provides compounds that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to imidazo[1,5-a]pyridine compounds that modulate iron and are useful for the treatment of diseases, particularly neurological diseases such as Parkinson's disease (PD), Alzheimer's 5 disease (AD), Alzheimer-type dementia, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and multiple system atrophy (MSA).

Photoinduced transition-metal- And external-photosensitizer-free intramolecular aryl rearrangementviaC(Ar)-O bond cleavage

The use of photochemical reactions that do not require expensive photocatalysts or transition metals is an environmentally friendly strategy for accomplishing a variety of structural transformations. Herein, we report a protocol for photoinduced transition-metal- and external-photocatalyst-free intramolecular heteroaryl/aryl rearrangement reactions of 2-heteroaryl/aryloxybenzaldehydes. The protocol was compatible with a variety of functionalities, including methyl, methoxy, cyano, ester, trifluoromethyl, halogen, and heteroaromatic rings. Control experiments suggested that the reaction proceededviaa photoinduced intramolecular heteroaryl/aryl rearrangement process involving photoexcitation of the aldehyde carbonyl group, radical addition, C-C bond formation and C(Ar)-O bond cleavage.

Pd-Catalyzed ortho Selective C–H Acyloxylation and Hydroxylation of Pyridotriazoles

An efficient protocol for the palladium-catalyzed direct ortho C–H acyloxylation of 3-phenyl-pyridotriazoles is described. The reaction was facilitated by PhI(OAc)2 (PIDA) as an oxidant and with carboxylic acids as acyloxylation reagents. The reaction is highly selective for mono acyloxylation of pyridotriazoles with various acids such as aliphatic, branched, and cyclic including adamantane carboxylic acids. When acetic anhydride was employed as acylation reagent, interesting 2-oxo-1-phenyl-1-(pyridin-2-yl)propyl acetates were obtained through the ring opening of pyridotriazoles. The key strategy is the employment of pyridotriazoles as a modifiable heterocycle; acyloxylation followed by the hydrolysis in one pot to yield the potential drug intermediates [(2-hydroxyphenyl)pyridin-2-yl]methanone in good yields.

NHC-Organocatalyzed CAr?O Bond Cleavage: Mild Access to 2-Hydroxybenzophenones

A Truce–Smiles rearrangement of acyl-anion equivalents generated by N-heterocyclic carbene (NHC) catalysis has been achieved. The developed method includes CAr?O, CAr?S, or CAr?N bond cleavage for the formation of a CAr?C bond and enables access to 2-hydroxybenzophenones, an important structural motif that is present in several bioactive natural products. By utilizing this procedure, the alkaloid taxilamine was synthesized in three steps. DFT calculations and control experiments support a classical SNAr mechanism with a catalyst-bound Meisenheimer-type intermediate. The method features mild reaction conditions, excellent functional-group tolerance, and a broad substrate scope, including various classes of (hetero)arenes.

MANGANESE-BASED CHELATE CONJUGATES FOR MOLECULAR MR IMAGING

Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presenc

The light-emitting compound and use this light-emitting compound of the organic light emitting diode device

An embodiment of the present invention provides an emitting compound of following formula: wherein “A” is represented by and “B” is represented by

Preparation and C-X reductive elimination reactivity of monoaryl Pd IV-X complexes in water (X = OH, OH2, Cl, Br)

Monohydrocarbyl palladium(IV) complexes bearing OH, OH2, Br, and Cl ligands at the metal and supported by facially chelating 1-hydroxy-1,1-bis(2-pyridyl)methoxide were readily prepared in water at 0 °C. These complexes reductively eliminate Ar-

Synthesis of triphenylmethane derivative: Bisacodyl

A new method for the synthesis of bisacodyl 1 is described. The key step involves migration of 2-pyridacyl group of phenyl pyridine-2-carboxylate 4 in AlCl3 at 160 °C to yield the intermediate 4-hydroxyphenyl (2-pyridyl) ketone 5a. The reaction of 5a with phenol using H3PO 4 gives 1. This method has advantage over the existing literature methods because easily available pyridine-2-carboxylic acid is used as a starting material instead of the less stable pyridine-2-carboxaldehyde.