23101-87-3

Basic information

• Product Name: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal
• Synonyms: 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal; Phthalimide, N-(1-formylethyl)-; Phthalimide, N-(1-formylethyl)-,
• CAS NO: 23101-87-3
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.1941
• Mol File: 23101-87-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 327.6°C at 760 mmHg
• Flash Point: 148°C
• Density: 1.336g/cm³
• Vapor Pressure: 0.0002mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal(23101-87-3)
• EPA Substance Registry System: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal(23101-87-3)

Safety Data

• Hazardous Substances Data: 23101-87-3(Hazardous Substances Data)

Upstream product

• 4306-25-6 (S)-2-phthalimidopropionyl chloride 
• 3485-84-5 N-vinylphthalimide 
• 201230-82-2 carbon monoxide 
• 2453-90-9 N-(3,3-diethoxypropyl)phthalimide 
• 70058-19-4 2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione 
• 4192-28-3 Phth-L-Ala-OH 
• 19967-57-8 bromo-2 propanal 
• 1074-82-4 potassium phtalimide 
• 53701-47-6 2-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 
• 32304-36-2 (+/-)N-(2-oxo-thietan-3-yl)-phthalimide 
• 105763-33-5 (2R,3R)-2-phthalimidobutane-1,2-diol 
• 29588-83-8 (R)-N-phthaloylalanine 
• 53100-40-6 (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride 
• 136918-14-4 phthalimide 

Downstream Products

• 29588-83-8 (R)-N-phthaloylalanine 
• 4192-28-3 Phth-L-Ala-OH 
• 82353-61-5 (R)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-methyl-pentanethioic acid S-phenyl ester 
• 82353-61-5 (2R,3S,4S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-methyl-pentanethioic acid S-phenyl ester 

Relevant articles and documents

Highly regioselective hydroformylation of enamides with phosphite ligands

The regioselective hydroformylation of enamides with a catalyst derived from monodentate phosphites and Rh(acac)(CO)2 was studied. In the hydroformylation of N-vinylphthalimide, all the biphenol-based ligands led to the branched aldehyde; the fastest reaction was observed when using a sterically bulky phosphite. The olefins (E)-N-propenylphthalimide, vinylpyrrolidone, vinylcaprolactam and vinylcarbazole were also investigated.

Supported Cobalt Nanoparticles for Hydroformylation Reactions

Hydroformylation of olefins has been studied in the presence of specific heterogeneous cobalt nanoparticles. The catalytic materials were prepared by pyrolysis of preformed cobalt complexes deposited onto different inorganic supports. Atomic absorption spectroscopy (AAS) measurements indicated a correlation of catalyst activity and cobalt leaching as well as a strong influence of the heterogeneous support on the productivity. These new, low-cost, easy-to-handle catalysts can substitute more toxic, unstable and volatile cobalt carbonyl complexes for hydroformylations on a laboratory scale.

Iterative asymmetric hydroformylation/Wittig olefination sequence

Over and over again: Various alkenes underwent the title reaction in the presence of rhodium/bis(diazaphospholane) complexes to give γ-chiral α,β-unsaturated carbonyl products (46-96 % yield) with high enantioselectivity (90-99 % ee). Iterative sequences