2362-10-9

Basic information

• Product Name: 1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane
• Synonyms: BIS(CHLOROMETHYL)TETRAMETHYLDISILOXANE;1,3-BIS(CHLOROMETHYL)-1,1,3,3-TETRAMETHYLDISILOXANE;1,3-BIS(CHLOROMETHYL)TETRAMETHYLDISILOXANE;1,3-Bis(Chlortomethyl)-1,1,3,3-Tetramethyldisiloxane;1,3-BIS(CHLOROMETHYL)-1,1,3,3-TETRAMETHYLDISILOXANE,99%(GC);1,3-Bis(chloromethyl)-1,1,3,3-tetramethylpropanedisiloxane;1,3-Dichloromethyl-1,1,3,3-Tetramethyl Disiloxane;BIS(CHLOROMETHYL)-1,1,3,3-TETRAMETHYLDISILOXANE
• CAS NO: 2362-10-9
• Molecular Formula: C₆H₁₆Cl₂OSi₂
• Molecular Weight: 231.27
• EINECS: 219-109-1
• Product Categories: Pharmaceutical Intermediates;Si (Classes of Silicon Compounds);Siloxanes;Si-O Compounds;Organometallic Reagents;Organosilicon
• Mol File: 2362-10-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: -90°C
• Boiling Point: 204 °C
• Flash Point: 73°C
• Appearance: /liquid
• Density: 1.05
• Vapor Pressure: 0.371mmHg at 25°C
• Refractive Index: 1.439
• Storage Temp.: 2-8°C
• Water Solubility: Not miscible or difficult to mix with water.
• BRN: 506631
• CAS DataBase Reference: 1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane(2362-10-9)
• EPA Substance Registry System: 1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane(2362-10-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 26-36/37/39-36
• RIDADR: UN 1993
• TSCA: Yes
• Hazardous Substances Data: 2362-10-9(Hazardous Substances Data)

Usage

Uses

1,3-Bis(chloromethyl)tetramethyldisiloxane is a useful bifunctional silylating agent.

InChI:InChI=1/C6H16Cl2OSi2/c1-10(2,5-7)9-11(3,4)6-8/h5-6H2,1-4H3

Upstream product

• 86392-92-9 (2-chloroethyl)(chloromethyl)dimethylsilane 
• 7664-93-9 sulfuric acid 
• 2344-80-1 Chloromethyltrimethylsilane 
• 75-77-4 chloro-trimethyl-silane 
• 1719-57-9 Chloro(chloromethyl)dimethylsilane 
• 7732-18-5 water 
• 17201-83-1 1-chloromethylpentamethyldisiloxane 
• 614-80-2 2-(acetylamino)phenol 
• 768-33-2 phenyldimethylsilyl chloride 
• 51048-35-2 N-[(chloromethyl)dimethylsilyl]dimethylamine 
• 421-85-2 Trifluoromethanesulfonamide 
• 1338487-87-8 2-bromoethyl(chloromethyl)dimethylsilane 
• 67-56-1 methanol 
• 107-46-0 Hexamethyldisiloxane 

Downstream Products

• 5360-04-3 (1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)diacetate 
• 18673-86-4 1,1,3,3-tetramethyl-1,3-bis-salicyloyloxymethyl-disiloxane 
• 18666-42-7 1,3-bis-(2,4-dichloro-benzoyloxymethyl)-1,1,3,3-tetramethyl-disiloxane 
• 4608-02-0 4,4,6,6-tetramethyl-5-oxa-4,6-disila-nonanedioic acid 
• 18147-06-3 2,2-dimethyl-1,4-dioxa-2-silacyclohexane 
• 1719-57-9 Chloro(chloromethyl)dimethylsilane 
• 135979-86-1 2,2,6,6-tetramethyl-1-oxa-4-benzyl-4-bromo-4-tellura-2,6-disilacyclohexane 
• 74-87-3 methylene chloride 
• 4515-13-3 1.1.3.3-Tetramethyl-1.3-bis-benzoyloxymethyl-disiloxan 
• 1585246-25-8 C₂₈H₄₀O₁₀Si₄ 
• 18753-32-7 1,3-bis[(p-carboxyphenyl)carbonyloxymethyl]-1,1,3,3-tetramethyldisiloxane 
• 123349-76-8 (1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene) bis(4-aminobenzoate) 

Relevant articles and documents

From the selective cleavage of the Si-O-Si bond in disiloxanes to zwitterionic, water-stable zinc silanolates

Zinc salts do Si-O's: Organosilicon chemistry is crucially determined by the high stability and chemical resistance of the Si-O-Si bond. The formation and structural existence of water-stable metallasilanolates demonstrate both the possibility to cleave the Si-O-Si bond with simple zinc compounds under mild conditions as well as the existence of such molecular metallasilanolates in the presence of water.

Dicationic disiloxane ionic liquids as heat transfer agents in vacuo

Bis(trifluoromethylsulfonyl)imidic dicationic liquids containing a disiloxane linker between the imidazole cations have been synthesized. Their thermal stability was estimated, and their melting points, viscosity, and volatility in vacuo were measured. The opportunity to use these ionic liquids as heat transfer agents in a dynamic vacuum has been shown.

Properties of dicationic disiloxane ionic liquids

A number of dicationic ionic liquids with a disiloxane linker between imidazolium cations and bis(trifluoromethylsulfonyl)imide anion were synthesized and characterized. Melting points, viscosity, and volatility in a vacuum were measured; the thermal and hydrolytic stability of ionic liquids were also studied. The dependence of the properties on the structure of substituents in the cation of the ionic liquid was demonstrated.

SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME

Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.