2362-10-9

Usage

Uses

1,3-Bis(chloromethyl)tetramethyldisiloxane is a useful bifunctional silylating agent.

InChI:InChI=1/C6H16Cl2OSi2/c1-10(2,5-7)9-11(3,4)6-8/h5-6H2,1-4H3

Upstream product

• 1719-57-9 Chloro(chloromethyl)dimethylsilane 
• 2344-80-1 Chloromethyltrimethylsilane 
• 5833-59-0 (1,1,3,3-tetramethyldisiloxane-1,3-diyl)dimethanol 
• 83622-79-1 diallyl(chloromethyl)methylsilane 
• 1825-61-2 Trimethylmethoxysilane 
• 18191-32-7 (chloromethyl)dimethylsilanol 
• 7664-93-9 sulfuric acid 
• 75-77-4 chloro-trimethyl-silane 
• 7732-18-5 water 
• 541-05-9 Hexamethylcyclotrisiloxane 
• 107-46-0 Hexamethyldisiloxane 
• 51048-35-2 N-[(chloromethyl)dimethylsilyl]dimethylamine 
• 614-80-2 2-(acetylamino)phenol 
• 421-85-2 Trifluoromethanesulfonamide 

Downstream Products

• 5360-04-3 (1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)diacetate 
• 18673-86-4 1,1,3,3-tetramethyl-1,3-bis-salicyloyloxymethyl-disiloxane 
• 18666-42-7 1,3-bis-(2,4-dichloro-benzoyloxymethyl)-1,1,3,3-tetramethyl-disiloxane 
• 4608-02-0 4,4,6,6-tetramethyl-5-oxa-4,6-disila-nonanedioic acid 
• 556-67-2 octamethylcyclotetrasiloxane 
• 17201-84-2 (chloromethyl)heptamethyltrisiloxane 
• 57592-62-8 (2-dimethylamino-ethyl)-trimethyl-ammonium; chloride 
• 1719-57-9 Chloro(chloromethyl)dimethylsilane 
• 82878-53-3 1,1,3,3-tetramethyl-1,3-bis(2-oxo-1-pyrrolidinomethyl)-1,3-disiloxane 
• 18147-06-3 2,2-dimethyl-1,4-dioxa-2-silacyclohexane 
• 74-87-3 methylene chloride 
• 82629-72-9 α,α'-(tetramethyldisiloxanylene)bis 
• 5833-59-0 (1,1,3,3-tetramethyldisiloxane-1,3-diyl)dimethanol 
• 18641-25-3 1,3-bis-(3,5-dinitro-benzoyloxymethyl)-1,1,3,3-tetramethyl-disiloxane 

Relevant academic research and scientific papers

From the selective cleavage of the Si-O-Si bond in disiloxanes to zwitterionic, water-stable zinc silanolates

Zinc salts do Si-O's: Organosilicon chemistry is crucially determined by the high stability and chemical resistance of the Si-O-Si bond. The formation and structural existence of water-stable metallasilanolates demonstrate both the possibility to cleave the Si-O-Si bond with simple zinc compounds under mild conditions as well as the existence of such molecular metallasilanolates in the presence of water.

Silylated derivatives of N-(2-hydroxyphenyl)acetamide: Synthesis and structure

The N-(2-(trimethylsilyloxy)phenyl)acetamide 1 was synthesized via reaction of N-(2-hydroxyphenyl)acetamide with chlorotrimethylsilane. Transsilylation of new compound 1 by chloro(chloromethyl)dimethylsilane leads to 4-acetyl-2,2-dimethyl-3,4-dihydro-2H-1,4,2-benzoxazasiline 3. The structures of the new compounds were investigated by 1H, 13C and 29Si NMR spectroscopy, X-ray single-crystal analysis, FTIR spectroscopy and DFT methods.

Dicationic disiloxane ionic liquids as heat transfer agents in vacuo

Bis(trifluoromethylsulfonyl)imidic dicationic liquids containing a disiloxane linker between the imidazole cations have been synthesized. Their thermal stability was estimated, and their melting points, viscosity, and volatility in vacuo were measured. The opportunity to use these ionic liquids as heat transfer agents in a dynamic vacuum has been shown.

Heteroatom-containing hydroxyalkyl disiloxane and preparation method and application thereof

The invention provides heteroatom-containing hydroxyalkyl disiloxane and a preparation method and application thereof. The preparation method comprises the steps of preparing a hydrolysis condensationproduct by using chlorosilane (II) as a starting material through a hydrolysis condensation reaction; and carrying out nucleophilic substitution or Williamson etherification reaction on a chloroalkylgroup in the hydrolysis condensation product and a mercapto group, an amine group or an alkoxide group in the hydroxyl compound (III) to obtain the heteroatom-containing hydroxyalkyl disiloxane. Thepreparation method is simple and convenient in steps, mild in reaction conditions, easy to realize and control in reaction conditions, short in preparation period, low in cost and high in target product yield and purity. The heteroatom-containing hydroxyalkyl disiloxane prepared by the preparation method disclosed by the invention can be used for preparing novel silicon-containing polymers such ashydroxyalkyl-terminated polysiloxane or organosilicon modified polyurethane (urea) or polyester, so that the material is endowed with better performance and wider application.

Properties of dicationic disiloxane ionic liquids

A number of dicationic ionic liquids with a disiloxane linker between imidazolium cations and bis(trifluoromethylsulfonyl)imide anion were synthesized and characterized. Melting points, viscosity, and volatility in a vacuum were measured; the thermal and hydrolytic stability of ionic liquids were also studied. The dependence of the properties on the structure of substituents in the cation of the ionic liquid was demonstrated.

Dicationic polysiloxane ionic liquids

Dicationic ionic liquids with bis(trifluoromethylsulfonyl)imide anions and dimethylimidazolic moieties linked by the polymeric siloxane chain in the cation structure have been synthesized. Thermal stability of the compounds synthesised was studied by TGA; glass transition temperatures, viscosities and volatility in vacuo were measured. Applicability of these ionic liquids as heat carriers under high dynamic vacuum conditions is shown.

SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME

Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

Synthesis and properties of dicationic ionic liquids containing a siloxane structural moiety

Five new ionic liquids formed by doubly charged cations containing a siloxane moiety and bis(trifluoromethylsulfonyl) imide anion are synthesized and characterized. Their thermal stability is studied by means of TGA; melting points (glass transition temperatures) and densities are measured. The temperature dependences of kinematic viscosity of the obtained ionic liquids are presented along with their approximations by the Vogel-Tammann-Fulcher equation.

Synthesis of (chloromethyl)dimethylsilanol

Abstract (Chloromethyl)dimethylsilanol was synthesized by the hydrolysis of (chloromethyl)dimethylchlorosilane, N-[(chloromethyl)dimethylsilyl]amines, or N-(chloromethyl)dimethylsilyl-N-methylamide of diisopropylphosphoric acid. Graphical abstract: [Figure not available: see fulltext.]

Synthesis and characterization of some bis(hydroxyalkyl)- and bis(hydroxyester)-functionalized disiloxanes

Novel hydroxyester disiloxanes (1,3-bis(6-hydroxyhexa noylmethyl)-1,1,3,3- tetramethyl disiloxane and 3-bis(2-hydroxypropanoylmethyl)tetramethyl disiloxane) were synthesized, and preparation of other known monomers, namely 1,3-bis(hydroxypropyl)-1,1,3,3-tetramethyl disiloxane, 1,3- bis(hydroxyethoxypropyl)-1,1,3,3-tetramethyl disiloxane and 1,3- bis(hydroxymethyl)-1,1,3,3-tetramethyl disiloxane was developed to obtain better yields and reduce production time and expense. All compounds were characterized by infrared spectroscopy, using 1H NMR, 13C NMR, and 29Si NMR and were reacted with diisocyanates, resulting in poly(siloxane-urethane) copolymers with unique properties.