2363-83-9Relevant articles and documents
Dual Functionalized Injectable Hybrid Extracellular Matrix Hydrogel for Burn Wounds
Bankoti, Kamakshi,Rameshbabu, Arun Prabhu,Datta, Sayanti,Goswami, Piyali,Roy, Madhurima,Das, Dipankar,Ghosh, Sudip Kumar,Das, Amit Kumar,Mitra, Analava,Pal, Sagar,Maulik, Dhrubajyoti,Su, Bo,Ghosh, Paulomi,Basu, Bikramajit,Dhara, Santanu
, p. 514 - 533 (2021)
Low strength and rapid biodegradability of acellular dermal matrix (ADM) restrict its wider clinical application as a rapid cell delivery platform in situ for management of burn wounds. Herein, the extracted ADM was modified by a dual cross-linking approach with ionic crosslinking using chitosan and covalent cross-linking using an iodine-modified 2,5-dihydro-2,5-dimethoxy-furan cross-linker, termed as CsADM-Cl. In addition, inherent growth factors and cytokines were found to be preserved in CsADM-Cl, irrespective of ionic/covalent crosslinking. CsADM-Cl demonstrated improvement in post crosslinking stiffness with a decreased biodegradation rate. This hybrid crosslinked hydrogel supported adhesion, proliferation, and migration of human foreskin-derived fibroblasts and keratinocytes. Also, the angiogenic potential of CsADM-Cl was manifested by chick chorioallantoic membrane assay. CsADM-Cl showed excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. Moreover, CsADM-Cl treated full thickness burn wounds and demonstrated rapid healing marked with superior angiogenesis, well-defined dermal-epidermal junctions, mature basket weave collagen deposition, and development of more pronounced secondary appendages. Altogether, the bioactive CsADM-Cl hydrogel established significant clinical potential to support wound healing as an apt injectable antibacterial matrix to encounter unmet challenges concerning critical burn wounds.
NOVEL COCAINE HAPTENS AND NANOFIBER-BASED COCAINE VACCINES
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Sheet 10 of 14, (2017/09/06)
Certain embodiments are directed to chemically defined self-adjuvanting cocaine vaccines composed of novel cocaine haptens and self-assembling peptide domains.
Preparation, crystal structure, and spectroscopic, chemical, and electrochemical properties of (2E,4E)-1,4-di(3-guaiazulenyl)-1,3-butadiene compared with those of (E)-1,2-di(3-guaiazulenyl)ethylene
Takekuma, Shin-Ichi,Yamamoto, Manami,Nakagawa, Aki,Iwata, Tomohiro,Minematsu, Toshie,Takekuma, Hideko
experimental part, p. 8318 - 8329 (2012/09/25)
Wittig reaction of (E)-3-(3-guaiazulenyl)propenal (11) with (3-guaiazulenylmethyl)triphenylphosphonium bromide (9) in ethanol containing NaOEt at 25 °C for 24 h under argon gives the title new (2E,4E)-1,3- butadiene derivative 4, in 33% isolated yield, which upon treatment with hexafluorophosphoric acid (i.e., 65% HPF6 aqueous solution) in tetrahydrofuran (=THF) at 25 °C for 1 h under aerobic conditions affords a new air (two-electron) oxidation product (E)-ethylene-1,2-bis(3- guaiazulenylmethylium) bis(hexafluorophosphate) (14), quantitatively, and further, zinc-reduction of 14 in trifluoroacetic acid (=CF3COOH) at 0 °C for 1 h under argon reverts 4, quantitatively. Along with the above interesting results, our discovered another preparation method, spectroscopic properties, crystal structure, and electrochemical behavior of 4, which serves as a strong two-electron donor and acceptor, compared with those of the previously reported (E)-1,2-di(3-guaiazulenyl)ethylene (3) are documented in detail. The title new (2E,4E)-1,3-butadiene derivative 4 serves as a strong two-electron donor. Therefore, the π-electron system 4 is readily converted into a new air (two-electron) oxidation product 14, quantitatively, the reaction conditions, of which are shown in the following scheme. Furthermore, the Zn-reduction of 14 in CF3COOH at 0 °C for 1 h under argon reverts 4, quantitatively. The title unique studies, with several interesting properties of 4 and 14, are reported.
