23839-33-0

Upstream product

• 2290-65-5 trimethylsilyl isothiocyanate 
• 108-94-1 cyclohexanone 
• 1147550-11-5 ammonium thiocyanate 
• 1056477-06-5 2-bromocyclohexanone 
• 333-20-0 potassium thioacyanate 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 57001-13-5 4,5,6,7-tetrahydro-2-benzothiazolinone 
• 26846-98-0 2-Chlor-4,5,6,7-tetrahydro-benzothiazol 
• 438568-89-9 2-bromo-4,5,6,7-tetrahydrobenzo[d]thiazole 

Relevant academic research and scientific papers

One-pot synthesis using supported reagents system: Conversion of β-dicarbonyl compounds to α-thiocyano-β-dicarbonyl compounds using CuBr2/Al2O3-KSCN/SiO2

Transformation of β-dicarbonyl compound 1 to α-thiocyano-α-dicarbonyl compounds 3 in one-pot was achieved by using supported reagents system CuBr2/Al2O3 - KSCN/SiO2, in which 1 reacts first with CuBr2/Al2O3 and the product, α-bromo-β-dicarbonyl compound 2 reacts with KSCN/SiO2 to give the final product 3 in good yield.

α-Selective C(sp3)-H Thio/Selenocyanation of Ketones with Elemental Chalcogen

A facile method is disclosed for the synthesis of α-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.

Graphene oxide: A promising carbocatalyst for the regioselective thiocyanation of aromatic amines, phenols, anisols and enolizable ketones by hydrogen peroxide/KSCN in water

Graphene oxide (GO), as a heterogeneous carbocatalyst, catalyzes the direct thiocyanation of a variety of arenes including aromatic amines, phenols, anisols and carbonyl compounds that possessing α-hydrogen in the presence of hydrogen peroxide and KSCN in water as a green media. This procedure is chemoselective, avoids the use of precious metals and toxic solvents and has a broad substrate scope. Easy removal from the reaction mixture and recyclability with no loss of activity are the key features of graphene oxide in this catalytic system.

Efficient α-thiocyanation of ketones using pyridinium hydrobromide perbromide

The direct α-thiocyanation of ketones with ammonium thiocyanate has been achieved using pyridinium hydrobromide perbromide under mild and neutral conditions to produce α-ketothiocyanates in excellent yields and with high selectivity. Copyright

A convenient, rapid, and general synthesis of α-oxo thiocyanates using clay supported ammonium thiocyanate

A very rapid, convenient, and general method for the synthesis of α-oxo thiocyanates has been described by using clay supported ammonium thiocyanate. The procedure avoids the use of additional catalyst, solvent, aqueous work-up and the yields are high. Moreover, the method is applicable for a variety of aryl, heteroaryl, alkyl α-halo carbonyls, β-keto tosylates, α-halo β-dicarbonyl, α-tosyl, β-dicarbonyl, alkyl halide, and alkyl tosylates.

Selectfluor: A novel and efficient reagent for the rapid α-thiocyanation of ketones

The direct α-thiocyanation of ketones with ammonium thiocyanate has been achieved using Selectfluor under mild and neutral conditions to produce α-ketothiocyanates, in excellent yields and with high selectivity.

I2O5 as a mild, inexpensive, and environmentally benign oxidant for the α-thiocyanation of ketones

-Thiocyanation of various ketones has been achieved using ammonium thiocyanate as a thiocyanation reagent and I2O5 as an oxidant in methanol solution at room temperature. Figure Presented.

NBS or DEAD as effective reagents in α-thiocyanation of enolizable ketones with ammonium thiocyanate

Ketones possessing α-hydrogen undergo smooth thiocyanation with ammonium thiocyanate in the presence of N-bromosuccinimide (NBS) at room temperature in acetonitrile under neutral conditions to produce the corresponding α-ketothiocyanates in excellent yiel

Heteropoly acids as heterogeneous and reusable catalyst for α-thiocyanation of ketones

Simple, efficient, and mild method for -thiocyanation of ketones in presence of heteropolyacid has been developed. This methodology offered -oxothiocyanates in good to excellent yields at room temperature in a highly selective manner. The catalyst could b

A simple and efficient thiocyanation of indoles, anilines and keto compounds catalyzed by a polystyrene resin amberlyst-15

Thiocyanation of various aromatic, heteroaromatic and enolizable ketone compounds has been achieved with ammonium thiocyanate in presence of polystyrene cation exchange resin, Amberlyst-15. All the reactions were carried out in acetonitrile at room temper