23839-33-0

Upstream product

• 2290-65-5 trimethylsilyl isothiocyanate 
• 108-94-1 cyclohexanone 
• 1147550-11-5 ammonium thiocyanate 
• 1056477-06-5 2-bromocyclohexanone 
• 333-20-0 potassium thioacyanate 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 57001-13-5 4,5,6,7-tetrahydro-2-benzothiazolinone 
• 438568-89-9 2-bromo-4,5,6,7-tetrahydrobenzo[d]thiazole 
• 26846-98-0 2-Chlor-4,5,6,7-tetrahydro-benzothiazol 

Relevant academic research and scientific papers

One-pot synthesis using supported reagents system: Conversion of β-dicarbonyl compounds to α-thiocyano-β-dicarbonyl compounds using CuBr2/Al2O3-KSCN/SiO2

Transformation of β-dicarbonyl compound 1 to α-thiocyano-α-dicarbonyl compounds 3 in one-pot was achieved by using supported reagents system CuBr2/Al2O3 - KSCN/SiO2, in which 1 reacts first with CuBr2/Al2O3 and the product, α-bromo-β-dicarbonyl compound 2 reacts with KSCN/SiO2 to give the final product 3 in good yield.

α-Selective C(sp3)-H Thio/Selenocyanation of Ketones with Elemental Chalcogen

A facile method is disclosed for the synthesis of α-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.

Graphene oxide: A promising carbocatalyst for the regioselective thiocyanation of aromatic amines, phenols, anisols and enolizable ketones by hydrogen peroxide/KSCN in water

Graphene oxide (GO), as a heterogeneous carbocatalyst, catalyzes the direct thiocyanation of a variety of arenes including aromatic amines, phenols, anisols and carbonyl compounds that possessing α-hydrogen in the presence of hydrogen peroxide and KSCN in water as a green media. This procedure is chemoselective, avoids the use of precious metals and toxic solvents and has a broad substrate scope. Easy removal from the reaction mixture and recyclability with no loss of activity are the key features of graphene oxide in this catalytic system.

A convenient, rapid, and general synthesis of α-oxo thiocyanates using clay supported ammonium thiocyanate

A very rapid, convenient, and general method for the synthesis of α-oxo thiocyanates has been described by using clay supported ammonium thiocyanate. The procedure avoids the use of additional catalyst, solvent, aqueous work-up and the yields are high. Moreover, the method is applicable for a variety of aryl, heteroaryl, alkyl α-halo carbonyls, β-keto tosylates, α-halo β-dicarbonyl, α-tosyl, β-dicarbonyl, alkyl halide, and alkyl tosylates.

Efficient α-thiocyanation of ketones using pyridinium hydrobromide perbromide

The direct α-thiocyanation of ketones with ammonium thiocyanate has been achieved using pyridinium hydrobromide perbromide under mild and neutral conditions to produce α-ketothiocyanates in excellent yields and with high selectivity. Copyright

Selectfluor: A novel and efficient reagent for the rapid α-thiocyanation of ketones

The direct α-thiocyanation of ketones with ammonium thiocyanate has been achieved using Selectfluor under mild and neutral conditions to produce α-ketothiocyanates, in excellent yields and with high selectivity.

I2O5 as a mild, inexpensive, and environmentally benign oxidant for the α-thiocyanation of ketones

-Thiocyanation of various ketones has been achieved using ammonium thiocyanate as a thiocyanation reagent and I2O5 as an oxidant in methanol solution at room temperature. Figure Presented.

NBS or DEAD as effective reagents in α-thiocyanation of enolizable ketones with ammonium thiocyanate

Ketones possessing α-hydrogen undergo smooth thiocyanation with ammonium thiocyanate in the presence of N-bromosuccinimide (NBS) at room temperature in acetonitrile under neutral conditions to produce the corresponding α-ketothiocyanates in excellent yiel

Mild and efficient method for-thiocyanation of ketones and-dicarbonyl compounds using bromodimethylsulfonium bromide-ammonium thiocyanate

An efficient and convenient method for-thiocyanation of ketones and-dicarbonyl compounds has been developed using a reagent combination of bromodimethylsulfonium bromide (BDMS) and ammonium thiocyanate in acetonitrile. The developed method is mild and gave good yield of the products at room temperature.

Heteropoly acids as heterogeneous and reusable catalyst for α-thiocyanation of ketones

Simple, efficient, and mild method for -thiocyanation of ketones in presence of heteropolyacid has been developed. This methodology offered -oxothiocyanates in good to excellent yields at room temperature in a highly selective manner. The catalyst could b