One-pot synthesis using supported reagents system: Conversion of β-dicarbonyl compounds to α-thiocyano-β-dicarbonyl compounds using CuBr2/Al2O3-KSCN/SiO2

Article abstract of DOI:10.1246/cl.1998.1091

Transformation of β-dicarbonyl compound 1 to α-thiocyano-α-dicarbonyl compounds 3 in one-pot was achieved by using supported reagents system CuBr₂/Al₂O₃ - KSCN/SiO₂, in which 1 reacts first with CuBr₂/Al₂O₃ and the product, α-bromo-β-dicarbonyl compound 2 reacts with KSCN/SiO₂ to give the final product 3 in good yield.