2393-61-5

Usage

Uses

Used in Pharmaceutical Industry:
3-ALPHA-HYDROXY-6-KETOCHOLANIC ACID is used as an antitumor agent for its potential role in combating cancer. It is believed to exert its effects by interfering with the cellular processes that contribute to tumor growth and progression, making it a promising candidate for further research and development in cancer therapeutics.
Used in Anticancer Applications:
3-ALPHA-HYDROXY-6-KETOCHOLANIC ACID is used as a therapeutic agent for its potential to target and inhibit the growth of cancer cells. It may modulate various signaling pathways and cellular processes that are dysregulated in cancer, thereby exhibiting inhibitory effects on tumor growth and progression.

InChI:InChI=1/C24H38O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-20,25H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,23-,24-/m1/s1

Upstream product

• 2868-48-6 methyl hyodeoxycholate 
• 2862-62-6 3α-ol-6-oxo-5β-24-cholanoic acid methyl ester 
• 6929-22-2 3,6-dioxocholanoic acid 
• 106439-47-8 3β-hydroxy-6-oxo-5β-cholanoic acid-(24) 
• 570-84-3 3β,6α-dihydroxy-5β-cholan-24-oic acid 
• 3436-34-8 3β.6β-dihydroxy-5β-cholanoic acid-(24) 
• 668-49-5 Murocholic acid 
• 83-49-8 Hyodeoxycholic Acid 
• 64-19-7 acetic acid 

Downstream Products

• 668-49-5 Murocholic acid 
• 83-49-8 Hyodeoxycholic Acid 
• 10573-17-8 3α-hydroxy-6-oxo-5α-cholan-24-oic acid 
• 474-22-6 6.7-seco-5α-cholanetrioic acid-(6.7.24) 
• 434-13-9 Lithocholic acid 
• 3057-04-3 chenodeoxycholic acid methyl ester 
• 2868-48-6 methyl hyodeoxycholate 
• 10190-22-4 3α,6α,7α-triol-5β-24-cholanoic acid methyl ester 
• 2862-62-6 3α-ol-6-oxo-5β-24-cholanoic acid methyl ester 

Relevant academic research and scientific papers

Preparation method of 3-hydroxy-6-ketocholanic acid with low cost and high yield

The invention discloses a preparation method of 3 alpha-hydroxy-6-keto-5 beta-cholestane-24-acid with low cost and high yield, which is characterized by comprising the following steps: adding hyodeoxycholic acid into a mixed solution of an organic solvent and water, and stirring to dissolve; adding bromide and acid, stirring and dissolving; bromate is added for reaction; adding a terminating agent, and stirring to terminate the reaction; adding water to crystallize the product; and carrying out solid-liquid separation, washing a solid product with water for multiple times, and drying to obtainthe 3 alpha-hydroxy-6-keto-5 beta-cholestane-24-acid. According to the method, a common and safe reagent is adopted, the hyodeoxycholic acid is selectively oxidized into the 3 alpha-hydroxy-6-keto-5beta-cholestane-24-acid under a relatively mild condition, the product purity is greater than 98.0%, and the yield is greater than 85%. The method has the advantages of cheap reagents, simple operation, high process reproducibility, simple post-treatment, high product purity and high yield, and can easily implement industrial production.

Synthetic method for 6-carbonyl lithocholic acid

The invention discloses a synthetic method for 6-carbonyl lithocholic acid. The synthetic method comprises the following steps of by adopting hyodeoxycholic acid as a starting material, sequentially performing 4-step reaction of 24-carboxyl esterification, oxidization of 3 alpha-OH and 6 alpha-OH into carbonyl groups, selective reduction and hydrolyzation to obtain a target product. The synthetictechnology is simple in flow, liable to control, wide in raw material source and available in raw material and can realize mass production.

Method for synthesizing lithocholic acid from hyodesoxycholic acid

The invention discloses a method for synthesizing lithocholic acid, comprising: using hyodesoxycholic acid as a start material, and performing two-step reaction of 6Alpha-OH selective oxidation and Huang Minglon reduction to synthesize the lithocholic acid. The start material herein is low in price and easy to obtain, the synthetic steps are short, posttreatment is simple, few side reactions are employed, and the method is applicable to industrial production.