2394-20-9Relevant articles and documents
Competitive immunoassay (Cat-EIA), a helpful technique for catalytic antibody detection. Part II
Taran,Renard,Creminon,Valleix,Frobert,Pradelles,Grassi,Mioskowski
, p. 1891 - 1894 (1999)
The Cat-EIA procedure, described in part I, was successfully applied to the screening of 5 different catalytic activities on a given set of 11 mAbs. The precautions required to devoid false-positive identification (preceding paper), were taken into account. Two catalytic activities were thus detected, including a newly thioacetal hydrolysis.
Competitive immunoassay (Cat-EIA), a helpful technique for catalytic antibody detection. Part I
Taran,Renard,Creminon,Valleix,Frobert,Pradelles,Grassi,Mioskowski
, p. 1887 - 1890 (1999)
A competitive immunoassay procedure for the screening of catalytic antibodies is reported. This screening approach (Cat-EIA) is a modification of the well-known Cat-ELISA technique avoiding the substrate modification step. It has been developed for a bimolecular reaction and has been tested on a high number of hybridoma clones. The current study explores for the first time the utility and feasibility of this method for the early detection of catalytic antibodies.
An efficient environmentally friendly CuFe2O4/SiO2catalyst for vanillyl mandelic acid oxidation in water under atmospheric pressure and a mechanism study
Mao, Haifang,Wang, Hongzhao,Meng, Tao,Wang, Chaoyang,Hu, Xiaojun,Xiao, Zuobing,Liu, Jibo
, p. 982 - 992 (2021/01/25)
With the aim of the green production of vanillin, a highly efficient environmentally friendly oxidation system was introduced to oxidize vanillyl mandelic acid (VMA) with a porous CuFe2O4/SiO2 component nano-catalyst in aqueous solution under atmospheric pressure. The N2 adsorption-desorption pattern indicated that CuFe2O4/SiO2 possessed a much higher specific surface area (49.98 m2 g-1) than that of CuFe2O4 (5.02 m2 g-1), which further indicated that the SiO2 substrate restrained the aggregation of CuFe2O4 nanoparticles. The conversion for VMA and selectivity for vanillin reached 98% and 96%, respectively, under atmospheric pressure. The excellent catalytic performance was attributed to the synergistic effect of the catalytic capacity of CuFe2O4 and the adsorption capacity for the reactant of SiO2. Simultaneously, the effect of different reaction conditions for catalyst activity and selectivity were investigated. Furthermore, the probable mechanism of VMA oxidation was investigated by in situ ATR-FTIR, H2-TPR, XPS and 1H NMR. More importantly, the decarboxylation was verified to proceed in basic conditions rather than in conventional acidic conditions. This journal is
Method for preparing 3-methoxy-4-hydroxymandelic acid
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Paragraph 0081-0145, (2019/07/16)
The invention belongs to the technical field of the condensation reaction of glyoxylic acid and phenols, and provides a method for preparing 3-methoxy-4-hydroxymandelic acid. The method comprises thefollowing steps: in the presence of a catalyst, a phenolic compound and a glyoxylic acid aqueous solution are contacted in an alkaline solution for the condensation reaction to produce 3-methoxy-4-hydroxymandelic acid, wherein the catalyst is selected from a metal-Salen complex which contain a ligand with a quaternary ammonium salt cation, or a catalytic system of a metal-Salen complex as a main catalyst and an organic base containing a cation as a co-catalyst. According to the method, the aldehyde group can be activated, the activity of the condensation reaction is improved, the selectivity of the p-condensation product is improved, and the yield of the p-product, namely 3-methoxy-4-hydroxymandelic acid, is improved.
