2396-76-1

Basic information

• Product Name: 1,2-Cyclohexanediol,1,2-diacetate, (1S,2R)-rel-
• Synonyms: 1,2-Cyclohexanediol,diacetate, (1R,2S)-rel- (9CI); 1,2-Cyclohexanediol, diacetate, cis- (8CI); cis-1,2-Cyclohexanediol diacetate; cis-1,2-Diacetoxycyclohexane
• CAS NO: 2396-76-1
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.2316
• Mol File: 2396-76-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 249.7°Cat760mmHg
• Flash Point: 115.4°C
• Density: 1.09g/cm³
• CAS DataBase Reference: 1,2-Cyclohexanediol,1,2-diacetate, (1S,2R)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanediol,1,2-diacetate, (1S,2R)-rel-(2396-76-1)
• EPA Substance Registry System: 1,2-Cyclohexanediol,1,2-diacetate, (1S,2R)-rel-(2396-76-1)

Safety Data

• Hazardous Substances Data: 2396-76-1(Hazardous Substances Data)

Upstream product

• 5837-71-8 trans-1-acetoxy-2-bromocyclohexane 
• 563-63-3 silver(I) acetate 
• 1792-81-0 cis-1,2-cyclohexane 
• 108-24-7 acetic anhydride 
• 14248-14-7 (+/-)-trans-1-acetoxy-2-(toluene-4-sulfonyloxy)-cyclohexane 
• 64-19-7 acetic acid 
• 33815-66-6 trans-2-chlorocyclohexyl acetate 
• 546-67-8 lead(IV) tetraacetate 
• 110-83-8 cyclohexene 
• 75-36-5 acetyl chloride 
• 27334-16-3 trans-2-chlorocyclohexyltellurium trichloride 
• 84672-88-8 2-methylene-(3ar,7ac)-hexahydro-benzo[1,3]dioxole 
• 7647-01-0 hydrogenchloride 
• 7429-37-0 trans-1,2-dibromocyclohexane 

Downstream Products

• 1792-81-0 cis-1,2-cyclohexane 
• 119180-48-2 (1S,2R)-1-acetoxy-2-hydroxycyclohexane 
• 86703-56-2 cis-1-acetoxycyclohexane-2-ol 
• 6628-80-4 trans-2-chlorocyclohexanol 
• 111138-43-3 (-)-(1R,2S)-1-acetoxy-2-hydroxycyclohexane 
• 110-82-7 cyclohexane 
• 622-45-7 cyclohexyl acetate 

Relevant articles and documents

Dihydroxylation of olefins catalyzed by zeolite-confined osmium(0) nanoclusters: An efficient and reusable method for the preparation of 1,2-cis-diols

Addressed herein is a novel, eco-friendly, recoverable, reusable and bottleable catalytic system developed for the dihydroxylation of various olefins yielding 1,2-cis-diols. In our protocol, zeolite-confined osmium(0) nanoclusters (zeolite-Os0) are used as reusable catalyst and H 2O2 served as a co-oxidant. Zeolite-Os0 are found to be highly efficient and selective catalysts for the dihydroxylation of a wide range olefins in an aqueous acetone mixture at room temperature. In all of the olefins surveyed, the catalytic dihydroxylation reaction proceeds smoothly and the corresponding 1,2-cis-diols are obtained in excellent chemical yield under the optimized conditions. The present heterogeneous catalyst system provides many advantages, such as being eco-friendly and industrially applicable over the traditional homogenous OsO4-NMO system for the dihydroxylation of olefins.

A multicatalyst system for the one-pot desymmetrization/oxidation of meso-1,2-alkane diols

Two is better than one: We demonstrate the viability of an organocatalytic reaction sequence along a short peptide backbone that carries two independent catalytic functionalities, which allow the rapid, one-pot acylative desymmetrization and oxidation of meso-alkane-1,2-diols to the corresponding acetylated acetoins with good yields and enantioselectivities (see scheme). Copyright

Adrenaline profiling of lipases and esterases with 1,2-diol and carbohydrate acetates

The adrenaline test for enzymes is a general back-titration procedure to detect 1,2-diols, 1,2-aminoalcohols and α-hydroxyketones reaction products of enzyme catalysis by colorimetry. The method was used to profile a series of esterases and lipases for their esterolytic activity on a series of carbohydrate and polyol acetates. Substrates were prepared by peracetylation and used for parallel microtiter-plate analysis of enzyme activities. This method can be used to achieve a rapid and automated characterization of a set of enzymes during HTS screening.