24167-50-8

Basic information

• Product Name: 4-CYANO-N,N-DIMETHYLBENZAMIDE
• Synonyms: EOS-61927
• CAS NO: 24167-50-8
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 24167-50-8.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CYANO-N,N-DIMETHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-N,N-DIMETHYLBENZAMIDE(24167-50-8)
• EPA Substance Registry System: 4-CYANO-N,N-DIMETHYLBENZAMIDE(24167-50-8)

Safety Data

• Hazardous Substances Data: 24167-50-8(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 124-40-3 dimethyl amine 
• 105-07-7 4-cyanobenzaldehyde 
• 32792-59-9 4-cyano-benzoic acid-(4-chloro-phenyl ester) 
• 18503-89-4 N,N-dimethylformamide diisopropyl acetal 
• 619-65-8 4-cyanobenzoic Acid 
• 506-59-2 N,N-dimethylammonium chloride 
• 18469-37-9 4-bromo-N,N-dimethylbenzamide 
• 86164-70-7 2-methyl-2-phenylmalononitrile 
• 187402-80-8 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate 
• 3058-39-7 4-iodobenzonitrile 
• 104-85-8 para-methylbenzonitrile 

Downstream Products

• 29339-10-4 N,N-dimethylterephthalamide 
• 105-07-7 4-cyanobenzaldehyde 
• 30611-20-2 1-(4-cyanophenyl)-1-pentanone 
• 1365271-67-5 4-(3-(fluorobenzoyl))benzonitrile 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 611-74-5 N,N-dimethylbenzamide 
• 29240-34-4 4'-butyl 4-cyanobenzoate 
• 1094362-53-4 4-(N-hydroxycarbamimidoyl)-N,N-dimethyl-benzamide 
• 1418291-84-5 N,N-dimethyl-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide 
• 84576-38-5 4-(1-oxo-2-phenylinden-3-yl)benzonitrile 
• 35525-86-1 4-cyano-N,N-dimethylbenzylamine 

Relevant articles and documents

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions

A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation

Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN). MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide under the reaction conditions. A variety of medicinally relevant benzonitriles can be made in good yields. Addition of NaBr to the reaction mixture allows for the use of more challenging aryl electrophiles such as aryl chlorides, tosylates, and triflates. Mechanistic investigations suggest that NaBr plays a role in facilitating oxidative addition with these substrates.