2418-52-2

Usage

Uses

Used in Pharmaceutical Industry:
D-THREITOL is used as a pharmaceutical compound for its potential therapeutic effects. It has been found to have beneficial properties for human health, including antioxidant and anti-inflammatory activities. Its presence in the extract of Hericium erinaceus, a mushroom known for its medicinal properties, suggests that D-THREITOL may contribute to the overall health benefits of this mushroom.
Used in Food Industry:
D-THREITOL is used as a natural sweetener and humectant in the food industry. Its sugar alcohol properties make it a suitable ingredient for low-calorie and sugar-free products, as it provides sweetness without the negative effects associated with high sugar consumption. Additionally, its ability to retain moisture can help improve the texture and shelf life of various food products.
Used in Cosmetics Industry:
D-THREITOL is used as a moisturizing agent in the cosmetics industry. Its hygroscopic nature allows it to help maintain the skin's moisture balance, making it a valuable ingredient in skincare products. It can be found in various formulations, such as creams, lotions, and serums, to provide hydration and improve the overall appearance of the skin.
Used in Chemical Synthesis:
D-THREITOL is used as a starting material or intermediate in the synthesis of various chemicals and pharmaceuticals. Its unique chemical structure makes it a versatile building block for the development of new compounds with potential applications in different industries.

Upstream product

• 95-43-2 D-threose 
• 50-99-7 glucose 
• 87-72-9 D-Xylose 
• 96-26-4 dihydroxyacetone 
• 141-46-8 Glycolaldehyde 
• 56-82-6 Glyceraldehyde 
• 58-86-6 D-xylose 
• 533-50-6 D-erythrulose 
• 59-23-4 D-Galactose 
• 9004-34-6 cellulose 
• 56-81-5 glycerol 
• 6974-12-5 1,4-dibromo-2-butene 
• 583-50-6 D-erythrose 
• 106-99-0 buta-1,3-diene 

Downstream Products

• 147-71-7 D-tartaric acid 
• 7208-40-4 (D)-threitol tetraacetate 
• 299-70-7 (S,S)-1,4-dibromo-butane-2,3-diol 
• 27088-70-6 trifluoroacetylated threitol 
• 95-43-2 D-threose 
• 173950-19-1 (2S,9R,6S,10R)-2,6-Di(hydroxymethyl)-1,3,5,7-tetraoxadecalin 
• 176519-86-1 (2R,3R)-1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-butane-2,3-diol 
• 208390-42-5 D-threitol-1,3:2,4-bis[3,4-bis(bromomethyl)phenylboronate] 
• 910658-45-6 (2R,3R)-2,3,4-trihydroxybutyl (S)-2-methylbutanoate 
• 57-55-6 propylene glycol 
• 909878-64-4 meso-erythritol 
• 107-21-1 ethylene glycol 
• 176590-77-5 (2R,3R)-2,3-dihydroxybutane-1,4-diyl dibenzoate 
• 64-18-6 formic acid 

Relevant academic research and scientific papers

Product Control and Insight into Conversion of C6 Aldose Toward C2, C4 and C6 Alditols in One-Pot Retro-Aldol Condensation and Hydrogenation Processes

Alcohols have a wide range of applicability, and their functions vary with the carbon numbers. C6 and C4 alditols are alternative of sweetener, as well as significant pharmaceutical and chemical intermediates, which are mainly obtained through the fermentation of microorganism currently. Similarly, as a bulk chemical, C2 alditol plays a decisive role in chemical synthesis. However, among them, few works have been focused on the chemical production of C4 alditol yet due to its difficult accumulation. In this paper, under a static and semi-flowing procedure, we have achieved the product control during the conversion of C6 aldose toward C6 alditol, C4 alditol and C2 alditol, respectively. About C4 alditol yield of 20 % and C4 plus C6 alditols yield of 60 % are acquired in the one-pot conversion via a cascade retro-aldol condensation and hydrogenation process. Furthermore, in the semi-flowing condition, the yield of ethylene glycol is up to 73 % thanks to its low instantaneous concentration.

Photocatalytic Conversion of Xylose to Xylitol over Copper Doped Zinc Oxide Catalyst

Abstract: In the present investigation, photocatalytic conversion of xylose by Copper (Cu) doped Zinc oxide (ZnO) was investigated under Ultraviolet Light emitting diode (UVA-LED) illumination. Photocatalysts were synthesized successfully by chemical prec

Hydrogenolysis of sorbitol into valuable C3-C2 alcohols at low H2 pressure promoted by the heterogeneous Pd/Fe3O4 catalyst

The hydrogenolysis of sorbitol and various C5-C3 polyols (xylitol; erythritol; 1,2- 1,4- and 2,3-butandiol; 1,2-propandiol; glycerol) have been investigated at low molecular hydrogen pressure (5 bar) by using Pd/Fe3O4, as heterogeneous catalyst and water as the reaction medium. Catalytic experiments show that the carbon chain of polyols is initially shortened through dehydrogenation/decarbonylation and dehydrogenation/retro-aldol mechanisms followed by a series of cascade reactions that include dehydrogenation/decarbonylation and dehydration/hydrogenation processes. At 240 °C, sorbitol is fully converted into lower alcohols with ethanol being the main reaction product in liquid phase.

CYCLIC COMPOUND

The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of autoimmune disease and/or inflammatory disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).

Effect of tungsten surface density of WO3-ZrO2 on its catalytic performance in hydrogenolysis of cellulose to ethylene glycol

One-pot hydrogenolysis of cellulose to ethylene glycol (EG) was carried out on WO3-based catalysts combined with Ru/C. To probe the active catalytic site for breaking the C-C bond of cellulose, a series of WO3-ZrO2 (WZr) catalysts were synthesized and systematically characterized with XRD, Raman, UV-Vis, H2-TPR, DRIFS and XPS techniques and N2 physisorption experiment. It was found that the WO3 crystallites became more easily reduced to W5+-OH species with increasing crystallite size or tungsten surface density of the WZr catalyst owing to the decrease of their absorption edge energy (AEE) originating from weakening their interaction with ZrO2 support. This, as a result, gave higher EG yield at higher tungsten surface density. The structure-activity relationship of the WZr catalyst reveals that the active catalytic site for cleaving the C2-C3 bond of the glucose molecule is the W5+-OH species.

CYCLIC COMPOUNDS

The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).

Kinetic insight into the effect of the catalytic functions on selective conversion of cellulose to polyols on carbon-supported WO3 and Ru catalysts

Efficient conversion of cellulose, the most abundant biomass on Earth, to chemicals in high yields remains a formidable challenge. Here, we report the marked change in the distribution of polyol products in the cellulose reaction on Ru/C and WO3/C, strongly depending on the competitive reactions of the glucose intermediate. WO3 crystallites not only promote, as a solid acid, the efficient hydrolysis of cellulose to glucose, but also catalyze the selective cleavage of the C-C bonds in glucose and other C6 sugar intermediates, leading to the formation of ethylene glycol and propylene glycol, in competition with the sugar hydrogenation to the corresponding C6 polyols (e.g. sorbitol) on Ru/C. The basic C support, behaving similar to other solid bases (i.e. MgO), catalyzes the isomerization of glucose into fructose, leading to the favored formation of propylene glycol instead of ethylene glycol. Such strong dependence of the product distribution on the catalytic functions is clarified by the kinetic analysis of the three competitive reactions of glucose, including its hydrogenation, isomerization and C-C bond cleavage. Importantly, such kinetic analysis can predict the maximum selectivity ratio of propylene glycol to ethylene glycol, which is 2.5, for example, at 478 K under the reaction conditions in this work, corresponding to a maximum yield of propylene glycol of ～71%. These understandings shed new insights into the selective conversion of cellulose, which provides guidance for the rational design of catalyst functions and tuning of reaction parameters towards the controllable synthesis of specific products from cellulose.

Unravelling the Ru-Catalyzed Hydrogenolysis of Biomass-Based Polyols under Neutral and Acidic Conditions

The aqueous Ru/C-catalyzed hydrogenolysis of biomass-based polyols such as erythritol, xylitol, sorbitol, and cellobitol is studied under neutral and acidic conditions. For the first time, the complete product spectrum of C2-C6 polyols is identified and, based on a thorough analysis of the reaction mixtures, a comprehensive reaction mechanism is proposed, which consists of (de)hydrogenation, epimerization, decarbonylation, and deoxygenation reactions. The data reveal that the Ru-catalyzed deoxygenation reaction is highly selective for the cleavage of terminal hydroxyl groups. Changing from neutral to acidic conditions suppresses decarbonylation, consequently increasing the selectivity towards deoxygenation.

A method for producing isomaltooligo hydrogenolytic

PROBLEM TO BE SOLVED: To provide a method for producing a hydrogenolysis product of erythritol, with which the erythritol is efficiently subjected to hydrogenolysis in mild conditions to provide butane-mono, di or triol.SOLUTION: The method for producing the hydrogenolysis product of erythritol includes a process of reacting the erythritol and hydrogen in the presence of a catalyst to prepare at least one of compound selected from butane-mono, di and triol, wherein, as the catalyst, a catalyst prepared by depositing at least one of metal component selected from a group comprising iridium, platinum, rhodium, cobalt, palladium and nickel is used.

A facile synthesis of vicinal cis-diols from olefins catalyzed by in situ generated MnxOy nanoaggregates

A novel protocol for the practical and green synthesis of vicinal cis-diols from 10.0 mmol olefins by using 5.0 mmol KMnO4 as oxidant and 30.0 mmol H2O2 as co-oxidant is reported. The presented procedure is easy to carry out and enables the direct transformation of linear and cyclic alkenes to the corresponding vicinal cis-diols. The synthesis of vicinal cis-diols by dihydroxylation of olefins with a KMnO4/H2O2 system was catalyzed by in situ generated MnxOy nanoaggregates. The use of H2O2 as a co-oxidant is the key for the protocol to synthesize vicinal cis-diols in high yields, because it assists the oxidation of MnxOy nanoaggregates, which have an active role in the oxidation reaction medium.