2432-11-3

Basic information

• Product Name: 2,6-Diphenylphenol
• Synonyms: 1,1':3',1''-Terbenzen-2'-ol;2,6-Diphenylphenol,97%;2,6-Diphenylphenol, 97% 25GR;2,6-Diphenylphenol, 97% 5GR;2,6-Diphenylphenol 98%;2'-HYDROXY-M-TERPHENYL;2,6-DIPHENYLPHENOL;[1,1':3',1''-Terphenyl]-2'-ol
• CAS NO: 2432-11-3
• Molecular Formula: C₁₈H₁₄O
• Molecular Weight: 246.3
• EINECS: 219-401-9
• Product Categories: Organic Building Blocks;Oxygen Compounds;Phenols;Building Blocks;C9 to C20+;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 2432-11-3.mol
• Article Data: 25

Chemical Properties

• Melting Point: 101-103 °C(lit.)
• Boiling Point: 349.31°C (rough estimate)
• Flash Point: 183.2 °C
• Appearance: White to off-white/Crystals or Powder
• Density: 1.0572 (rough estimate)
• Refractive Index: 1.4700 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.02±0.10(Predicted)
• BRN: 2051224
• CAS DataBase Reference: 2,6-Diphenylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Diphenylphenol(2432-11-3)
• EPA Substance Registry System: 2,6-Diphenylphenol(2432-11-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 2432-11-3(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white crystals or powder

Uses

2,6-Diphenylphenol has been used:as ligand during the synthesis of reduced coordination (less than 6), unchelated manganese oxygen cluster systemsin the preparation of derivatives of pyrazine-2,3-dicarbonitrile, precursor required for the synthesis of octaazaphthalocyanine (AzaPc) derivatives

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 2784, 1986 DOI: 10.1021/jo00364a031

General Description

2,6-Diphenylphenol reacts with with (n)BuLi, NaH, KH, or Rb or Cs metal in benzene to yield the solvent-free complexes [M(OAr)]x.

Upstream product

• 101-84-8 diphenylether 
• 1623-99-0 phenyl sodium 
• 24344-21-6 2,6-bis(1-cyclohexenyl)cyclohexanone 
• 6738-04-1 2-phenoxy-1,1'-biphenyl 
• 3293-32-1 2,6-dicyclohexylidenecyclohexanone 
• 90-43-7 2-Phenylphenol 
• 71-43-2 benzene 
• 67-56-1 methanol 
• 10368-54-4 2,6-diphenyl-1,4-benzoquinone diazide 
• 20834-02-0 cis-2,6-diphenylcyclohexanone 
• 507233-69-4 triphenyl bismuth ⁽²⁺⁾; dichloride 
• 67-63-0 isopropyl alcohol 
• 108-95-2 phenol 
• 1746-13-0 allyl phenyl ether 

Downstream Products

• 92-94-4 [1,1';4',1'']terphenyl 
• 3550-01-4 1,5,1',5'-tetraphenyl-[3,3']bicyclohexa-1,4-dienylidene-6,6'-dione 
• 124786-91-0 2,6-Diphenyl-4,4'-(1-methylethylidene)bisphenol 
• 124786-92-1 2,2',6,6'-Tetraphenyl-4,4'-(1-methylethylidene)bisphenol 
• 57196-29-9 5'-[9-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-9H-fluoren-9-yl]-[1,1';3',1'']terphenyl-2'-ol 
• 20104-41-0 2,6-diphenyl-4-(2,6-diphenylphenoxy)anisole 
• 57502-72-4 6-Oxo-1,5-diphenyl-2,4-cyclohexadienylacetat 
• 103230-41-7 cis-WCl₄(2,6-diphenylphenoxide) 
• 112347-60-1 Ta(OC₆H₃(C₆H₅)2)3(NCH₃)(NHCH₃CH₃) 

Relevant articles and documents

The effect of topologically controlled coulombic interactions on the regioselectivity of the reductive cleavage of alkyl phenyl ethers

The importance of electrostatic effects in the chemical evolution of charged intermediates of the radical anion type is demonstrated. Thus, the regioselectivity of the electron transfer-induced reductive cleavage of alkyl 2,6-diphenylphenyl ethers and alkyl 2,6-dimethoxyphenyl ethers is completely reversed when a positive charge is placed in a controlled manner near the alkyl ether bond.

Through-Space Polar-π Interactions in 2,6-Diarylthiophenols

Molecular recognition between polar groups and aromatic molecules is fundamentally important to rational drug design. Although it has been well established that many polar functionalities interact with electron-rich aromatic residues through energetically favorable polar-π interactions, there is a limited understanding of the association between thiols and aromatic systems. Herein we report physical-organic chemistry studies on 2,6-diarylthiophenols that possess the central thiophenol ring and two flanking aromatic rings with tunable electronic properties caused by substituents at distant para position. Hammett analysis revealed that pKa values and proton affinities correlate well with Hammett sigma values of substituents. Additional energy decomposition analysis supported the conclusion that both through-space SH-π interactions and S?-π interactions contribute to intramolecular stabilization of 2,6-diarylthiophenols.

Preparation method of multi-substituted phenol

The invention provides a preparation method of multi-substituted phenol. According to the preparation method, raw materials, namely alkyl ketone and alkene, are subjected to condensation-aromatizationunder action of a catalyst to obtain multi-substituted phenol. Compared with the prior art, the preparation method has the advantages that the raw materials are easy to obtain, the yield is high, cost is low since use of expensive metallic catalysts is avoided, and the preparation method is suitable for industrial production and the like.