247179-37-9

Basic information

• Product Name: 1-(4-Fluorophenyl)-2-Methoxyethanone
• Synonyms: 1-(4-Fluorophenyl)-2-Methoxyethanone
• CAS NO: 247179-37-9
• Molecular Formula: C₉H₉FO₂
• Molecular Weight: 168.1649632
• Mol File: 247179-37-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-Fluorophenyl)-2-Methoxyethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)-2-Methoxyethanone(247179-37-9)
• EPA Substance Registry System: 1-(4-Fluorophenyl)-2-Methoxyethanone(247179-37-9)

Safety Data

• Hazardous Substances Data: 247179-37-9(Hazardous Substances Data)

Usage

Type of compound

Aromatic ketone

Structural features

4-fluorophenyl group
Methoxyethyl moiety

Applications

Reagent in organic synthesis
Pharmaceutical research
Development of new drugs (due to various biological activities)
Preparation of other organic compounds
Flavor and fragrance ingredient

Industry applications

Wide range of industries, including pharmaceutical, chemical, and flavor & fragrance industries.

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 1738-36-9 2-methoxyacetonitrile 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1280738-13-7 ((1-(4-fluorophenyl)vinyl)oxy)triisopropylsilane 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 67-56-1 methanol 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 124-41-4 sodium methylate 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 132812-72-7 4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctane[b]pyridine-(1H)-ketone 
• 4640-67-9 3-(4-fluorophenyl)-3-oxopropionitrile 
• 654674-10-9 (α-methoxy-4-fluorobenzyl)-(4-fluorophenyl)-ketone 

Relevant articles and documents

Intermolecular C-O Bond Formation with Alkoxyl Radicals: Photoredox-Catalyzed α-Alkoxylation of Carbonyl Compounds

Due to the high reactivity of alkoxyl (RO·) radicals and their propensity to easily undergo β-scission or Hydrogen Atom Transfer (HAT) reactions, intermolecular alkoxylations involving RO· radicals are barely described. We report herein for the first time the efficient intermolecular trapping of alkoxyl radicals by silyl enol ethers. This photoredox-mediated protocol enables the introduction of both structurally simple and more complex alkoxy groups into a wide range of ketones and amides.

NOVEL THYROMIMETICS

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, X1, X2, Q, R1, R2 and n are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

Direct Synthesis of α-Alkoxy Ketones by Oxidative C–O Bond Formation

A convenient method to prepare α-alkoxy ketones has been developed by oxidative coupling of aryl methyl ketones and alcohols. With aqueous tert-butyl hydroperoxide (6.0 equiv.) as the oxidant, tetrabutylammonium iodide (20 mol-%) as the catalyst, and TsNHNH2(1.0 equiv.) as the additive, ketones underwent direct alkoxylation to give α-methoxy or α-ethoxy ketones in moderate to good yields.