24896-23-9Relevant academic research and scientific papers
A novel approach for the synthesis of 5-substituted tetrazole derivatives from primary amides in mild one-step method
El-Ahl, Abdel-Aziz S.,Elmorsy, Saad S.,Elbeheery, Akram H.,Amer, Fathy A.
, p. 1257 - 1260 (1997)
A new mild one-step method for the conversion of primary acid amides to 5-substituted tetrazoles in nearly quantitative yields employing triazidochlorosilane (TACS) is reported.
Efficient uncatalyzed conversion of primary and secondary thioamides into 1-substituted, 5-substituted, 1, 5-disubstituted and annulated tetrazoles
El-Ahl, Abdel-Aziz S.,Amer, Fatty A.,Elbeheery, Akram H.
experimental part, p. 2226 - 2235 (2012/03/26)
Unprecedented high-yield simple and mild conversion of primary aliphatic and aromatic thioamides into 5-substituted tetrazoles on treatment with a combination of tetrachlorosilane and sodium azide in refluxing acetonitrile has been achieved. Secondary acyclic, cyclic, and heterocyclic thioamides could also be transformed in high yields into 1-substituted, 1,5-disubstituted, or annulated tetrazoles under the same reaction condition. Copyright Taylor & Francis Group, LLC.
Heterocyclic compouds
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, (2008/06/13)
A compound of the general formula wherein: n is 0 or 1; M1 is an amino group; Q is an aromatic heterocyclic group containing a basic nitrogen atom; M2 is an imino group; L is a template group; and A is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group; and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved. Novel compounds are also disclosed.
TETRAZOLES. 31. KINETICS OF THE REACTION OF NITRILES WITH ALKYLAMMONIUM AZIDES. FORMATION OF 5-SUBSTITUTED TETRAZOLES
Ostrovskii, V. A.,Poplavskii, V. S.,Koldobskii, G. I.,Erusalimskii, G. B.
, p. 1027 - 1030 (2007/10/02)
5-Substituted tetrazoles are formed by the reaction of nitriles with mono-, di-, and trialkylammonium azides in aprotic dipolar solvents and alcohols.Tetraalkylammonium azides do not react with nitriles.The formation of 5-substituted tetrazoles occurs by a 1,3-dipolar cycloaddition mechanism.Electron-accepting substituents increase the reactivity of nitriles significantly while the structure of the alkylammonium azide and the solvent polarity have no significant effect on the reaction rate.
