25173-12-0

Usage

Uses

Used in Pharmaceutical Industry:
(3-oxo-indan-1-yl)-acetic acid is utilized as a key intermediate in the synthesis of various pharmaceutical products, contributing to the development of new medications.
Used in Pharmaceutical Research and Development:
(3-oxo-indan-1-yl)-acetic acid is employed as a compound of interest for its potential biological activities, such as anti-inflammatory and antinociceptive properties, which are crucial for the treatment of pain and inflammation.
Used in Neurological Disorders Treatment:
(3-oxo-indan-1-yl)-acetic acid is studied for its potential application in the treatment of neurological disorders, indicating its possible role in managing conditions affecting the nervous system.

InChI:InChI=1/C11H10O3/c12-10-5-7(6-11(13)14)8-3-1-2-4-9(8)10/h1-4,7H,5-6H2,(H,13,14)

Upstream product

• 4160-80-9 3-phenylglutaric acid anhydride 
• 4165-96-2 3-phenylglutaric acid 
• 7664-93-9 sulfuric acid 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 71-43-2 benzene 
• 100-52-7 benzaldehyde 
• 859770-38-0 ethyl 2-(3-oxo-2,3-dihydro-1H-inden-1-yl)acetate 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 480-90-0 1H-inden-1-one 
• 13277-74-2 diethyl 2,4?diacetyl?3?phenylpentanedioate 
• 216586-10-6 3-phenyl-glutaroyl chloride 

Downstream Products

• 30223-70-2 methyl 2-(3-oxo-2,3-dihydro-1H-inden-1-yl)acetate 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Relevant academic research and scientific papers

(±)-3-indanone-1-acetic acid: Heterochiral catemeric hydrogen bonding in a δ-keto acid

The crystal structure of (±)-2,3-dihydro-3-oxo-1H-indeneacetic acid, C11H10O3, involves carboxyl-to-ketone hydrogen-bonding catemers [O...O 2.691 (2) A] of an unusual type. Hydrogen bonds progress from the carboxyl H atom of one molecule to the ketone O (01) atom of a glide-related enantiomer, resulting in heterochiral chains. Parallel screw-related hydrogen-bonding chains proceed in counter-directional pairs through the cell. Two different close contacts (2.49 and 2.58 A) are found between the carboxyl C=O group and H atoms on neighboring molecules.

Sulfoxonium-Ylide-Directed C-H Activation and Tandem (4 + 1) Annulation

Rh(III)-catalyzed C-H activation and cyclization of sulfoxonium ylide with acrylates leads to an efficient synthesis of indanone derivatives. The reaction proceeds under mild and external metal-oxidant-free conditions. The sulfoxonium ylide acts as a trac

Facile Synthesis of Spirocyclic Lactams from β-Keto Carboxylic Acids

A facile synthesis of spirocyclic lactams starting from β-keto carboxylic acids via a one-pot cascade reaction involving a Curtius rearrangement and an intramolecular nucleophilic addition of the enol carbon to the isocyanate intermediate is reported. The same conditions have also been used for the generation of fused cyclic lactams with similar good yields. The synthetic value of this method has been demonstrated by efficient synthesis of tetracyclic spirolactam 8 and pentacyclic spirolactam 9.

Aminoindanes

The present invention relates to therapeutically active novel aminoindanes of formula (I). Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of

Application of the benzene sector and the benzene chirality rules to perhydrobenzocycloalkenes and related compounds

Enantioenriched 1-substituted indans were prepared from (R)-1-indancarboxylic acid and (R)-1-indanylacetic acid as model compounds for the correlation of their absolute configurations with the sign of the 1Lb Cotton effects (CEs) from about 250 to 270 nm in their circular dichroism spectra. The CEs are the result of vibronic and induced contributions to the rotational strength, and their sign is in agreement with that predicted on the basis of the benzene sector and the benzene chirality rules. The application of these rules to other, nonplanar perhydrobenzocycloalkenes evolves into sector sign projections suggested earlier to correlate the sign of 1Lb CEs of enantiopure 1,2,3,4-tetrahydronaphthalenes and 1,2,3,4-tetrahydroisoquinolines with their absolute configurations.