2549-30-6

Upstream product

• 100-52-7 benzaldehyde 
• 119-51-7 1-phenyl-1,2-propanedione 2-oxime 
• 17019-26-0 (E)-2-(hydroxyimino)-1-phenylpropan-1-one 
• 93-55-0 1-phenyl-propan-1-one 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 

Downstream Products

• 27492-44-0 3-benzoyloxy-4-methyl-2,5-diphenyl-2,3-dihydro-oxazole-2-carbonitrile 
• 2549-33-9 4-(chloromethyl)-2,5-diphenyloxazole 
• 144936-85-6 (E)-6-{2-[2-(2,5-Diphenyl-oxazol-4-yl)-ethyl]-[1,3]dioxolan-2-yl}-hex-5-en-2-ol 
• 144763-00-8 4-(3-Dioxolan-8-hydroxy-5-E-nonen)-2,5-diphenyloxazole 
• 144993-60-2 N,N-Dibenzoyl-4-dioxolan-9-hydroxy-6-E-decenamide 
• 144762-97-0 4-(4-Triphenylphosphoranylidene-3-butanon)-2,5-diphenyloxazole 
• 144936-88-9 4-<3-Oxo-8-(2',2',2'-trichloroethylcarbonoyl)-4-E-nonen>-2,5-diphenyloxazole 
• 144993-59-9 4-<3-Dioxolan-8-(2',2',2'-trichloroethylcarbonoyl)-5-E-nonen>-2,5-diphenyloxazole 
• 144936-84-5 Carbonic acid (E)-5-{2-[2-(2,5-diphenyl-oxazol-4-yl)-ethyl]-[1,3]dioxolan-2-yl}-1-methyl-pent-4-enyl ester 2,2,2-trichloro-ethyl ester 
• 24248-61-1 2-(2,5-diphenyloxazol-4-yl)acetonitrile 
• 2549-37-3 (2,5-diphenyl-oxazol-4-yl)-methanethiol 
• 2549-35-1 2,5-diphenyl-4-hydroxymethyloxazole 
• 2549-38-4 4-(2,5-diphenyl-oxazol-4-ylmethyl)-morpholine 
• 2549-34-0 1-(2,5-diphenyl-oxazol-4-ylmethyl)-piperidine 

Relevant academic research and scientific papers

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

Synthesis of 2,4,5-Trisubstituted Oxazoles

2,4,5-Trisubstituted oxazoles were synthesized in good yields starting from α-methylene ketones by nitrosation, condensation with aldehydes and reduction with zinc in acetic acid at 40 deg C. (5-Methyl-2-phenyloxazol-4-yl)ethanol was prepared by reduction of ethyl (5-methyl-2-phenyloxazol-4-yl)acetate with LiAlH4.