256399-59-4

Upstream product

• 139-02-6 sodium phenoxide 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 10606-73-2 ethyl 2-chloro-2-phenylacetate 
• 108-95-2 phenol 
• 22065-57-2 ethyl 2-phenyldiazoacetate 
• 5413-05-8 ethyl 2-phenylacetoacetate 
• 101-97-3 Ethyl 2-phenylethanoate 

Downstream Products

• 3117-38-2 2-phenoxy-2-phenylacetic acid 
• 32191-68-7 phenoxy-phenyl-acetic acid amide 
• 136093-43-1 2-(1-Phenoxy-1-phenyl-ethyl)-4,5-dihydro-1H-imidazole 
• 136093-41-9 2-(Phenoxy-phenyl-methyl)-4,5-dihydro-1H-imidazole 
• 136093-38-4 2-Phenoxy-2-phenyl-propionitrile 
• 32121-27-0 α-phenoxy-α-phenylacetonitrile 
• 71621-33-5 2-(α-phenoxy-benzyl)-morpholine hydrochloride 
• 93852-38-1 2-Chloro-N-(2-hydroxy-3-phenoxy-3-phenyl-propyl)-acetamide 
• 93886-29-4 6-(Phenoxy-phenyl-methyl)-morpholin-3-one 
• 71621-12-0 2-hydroxy-3-phenyl-3-phenoxy-propylamine 
• 107449-33-2 Phenoxy-phenyl-acetyl chloride 
• 133534-42-6 2-hydroxy-3-phenoxy-3-benzenepropanenitrile 
• 133534-41-5 Phenoxy-phenyl-acetaldehyde 

Relevant academic research and scientific papers

Isolation of a Reactive Tricoordinate α-Oxo Gold Carbene Complex

The [(P,P)Au=C(Ph)CO2Et]+ complex 3 [where (P,P) is an o-carboranyl diphosphine ligand] was prepared by diazo decomposition at ?40 °C. It is the first α-oxo gold carbene complex to be characterized. Its crystallographic structure was determined and DFT calculations have been performed, unraveling the key influence of the chelating (P,P) ligand. The gold center is tricoordinate and the electrophilicity of the carbene center is decreased. Complex 3 mimics transient α-oxo gold carbenes in a series of catalytic transformations, and provides support for the critical role of electrophilicity in the chemoselectivity of phenol functionalization (O?H vs. C?H insertion).

Supramolecularly regulated copper-bisoxazoline catalysts for the efficient insertion of carbenoid species into hydroxyl bonds

The catalytic insertion of copper carbenoids into O-H bonds affords synthetically useful α-alkyl/aryl-α-alkoxy/aryloxy derivatives. Herein, the design, preparation and application of supramolecularly regulated copper(i) complexes of bisoxazoline ligands is reported. We have demonstrated that the catalytic performance of these systems can be modulated by the use of an external molecule (i.e.the regulation agent), which interacts with a polyethyleneoxy chain on the ligand (i.e.the regulation site)viasupramolecular interactions. This approach has been applied to an array of structurally diverse alcohols (cycloalkyl, alkyl and aryl derivatives). Moreover, we have used this methodology to synthesise advanced synthetic intermediates of biologically relevant compounds.

Catalytic O-H bond insertion reactions using surface modified sewage sludge as a catalyst

Developing a greener, sustainable catalyst is a very important but challenging task in organic synthesis. Herein, for the first time, we choose more economical and greener surface modified sewage sludge-derived carbonaceous materials (SW) treated by perch

CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST

The present invention relates to a compound shown in formula (II) or a pharmaceutically acceptable salt thereof and an application of the same in preparing a drug for treating a disease related to angiotensin II receptor type 2 (AT2R).(II)

Acid catalytic synthesis method and application of phenoxyacetate derivatives

The invention discloses an acid catalytic synthesis method and application of phenoxyacetate derivatives. In the method, an O-H insertion reaction is performed on one diazo ester compound and one phenolic compound by an acid catalyst to form a C-O bond to

Application of sludge carbon catalyst with modified surface

The invention discloses application of a sludge carbon catalyst with a modified surface in reaction of inserting O-H into carbene and constructing a C-O bond. Alpha-diazonium ester and a phenolic compound serve as starting materials, modified sludge carbo

Carbene X[sbnd]H bond insertions catalyzed by copper(I) macrocyclic pyridine-containing ligand (PcL) complexes

A catalytic system comprising copper(I) and macrocyclic pyridine-containing ligands (Pc-L) proves capable of promoting carbene Si[sbnd]H bond insertions using diazo compounds as the carbene source. This catalytic system showed broad scope and a remarkable robustness as indicated by high TON numbers (up to 30000). Moreover, the use of enynones as carbene sources proved also feasible in hydrosilane insertion using this catalytic system. Finally, the insertion in O[sbnd]H and N[sbnd]H bonds of phenols and anilines, respectively, has been also demonstrated.

(C6F5)3B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with α-Aryl α-Diazoesters

The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with α-aryl α-diazoacetates with commercially available (C6F5)3B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.

INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.

Switched enantiopreference of Humicola lipase for 2-phenoxyalkanoic acid ester homologs can be rationalized by different substrate binding modes

Humicola lanuginosa lipase was used for enantioselective hydrolyses of a series of homologous 2-phenoxyalkanoic acid ethyl esters. The enantioselectivity (E-value) of the enzyme changed from an (R)-enantiomer preference for the smallest substrate, 2-pheno