3117-38-2

Usage

Uses

Used in Pharmaceutical Industry:
Phenoxy(phenyl)acetic acid is used as a precursor in the synthesis of various pharmaceuticals, such as diuretics and antihistamines, due to its ability to serve as a building block for the development of these medications.
Used in Dye and Perfume Industry:
Phenoxy(phenyl)acetic acid is used as a starting material in the production of dyes and perfumes, contributing to the creation of a variety of colorants and fragrances.
Used in Chemical Industry:
Phenoxy(phenyl)acetic acid is used as a building block in the synthesis of various organic compounds, highlighting its importance in the chemical industry for creating a wide array of products.
Used in Research and Development:
Phenoxy(phenyl)acetic acid is studied for its potential biological and pharmacological properties, such as anti-inflammatory and antioxidant effects, which may lead to the development of new therapeutic agents.

Upstream product

• 256399-59-4 ethyl 2-phenoxy-2-phenylethanoate 
• 100-67-4 potassium phenolate 
• 10606-73-2 ethyl 2-chloro-2-phenylacetate 
• 108-95-2 phenol 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 19078-72-9 bromo(phenyl)acetyl chloride 
• 4870-65-9 2-bromophenylacetic acid 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 

Downstream Products

• 93-99-2 benzoic acid phenyl ester 
• 958029-28-2 (–)-methyl 2-phenoxy-2-phenylacetate 
• 71621-33-5 2-(α-phenoxy-benzyl)-morpholine hydrochloride 
• 93852-38-1 2-Chloro-N-(2-hydroxy-3-phenoxy-3-phenyl-propyl)-acetamide 
• 93886-29-4 6-(Phenoxy-phenyl-methyl)-morpholin-3-one 
• 71621-12-0 2-hydroxy-3-phenyl-3-phenoxy-propylamine 
• 133534-42-6 2-hydroxy-3-phenoxy-3-benzenepropanenitrile 
• 133534-41-5 Phenoxy-phenyl-acetaldehyde 
• 88-89-1 2,4,6-Trinitrophenol 
• 100-52-7 benzaldehyde 
• 107449-33-2 Phenoxy-phenyl-acetyl chloride 

Relevant academic research and scientific papers

CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST

The present invention relates to a compound shown in formula (II) or a pharmaceutically acceptable salt thereof and an application of the same in preparing a drug for treating a disease related to angiotensin II receptor type 2 (AT2R).(II)

Access to Optically Enriched α-Aryloxycarboxylic Esters via Carbene-Catalyzed Dynamic Kinetic Resolution and Transesterification

Optically active α-aryloxycarboxylic acids and their derivatives are important functional molecules. Disclosed here is a carbene-catalyzed dynamic kinetic resolution and transesterification reaction for access to this class of molecules with up to 99% yields and 99:1 er values. Addition of a chiral carbene catalyst to the ester substrate leads to two diastereomeric azolium ester intermediates that can quickly epimerize to each other and thus allows for effective dynamic kinetic resolution to be realized. The optically enriched ester products from our reaction can be quickly transformed to chiral herbicides and other bioactive molecules.

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

Potential antidepressant agents. α-Aryloxy-benzyl derivatives of ethanolamine and morpholine

Various α-aryloxy-benzyl derivatives of ethanolamine and morpholine were synthesized and tested as potential antidepressant agents. A morpholine derivative, the 2-[α-(2-ethoxy-phenoxy) benzyl]morpholine, showed outstanding activity in the antireserpine te