25902-95-8

Basic information

• Product Name: 4-ethoxy-1-ethyl-2(1H)-pyrimidinone
• Synonyms: 4-ethoxy-1-ethyl-2(1H)-pyrimidinone
• CAS NO: 25902-95-8
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168
• Mol File: 25902-95-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ethoxy-1-ethyl-2(1H)-pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxy-1-ethyl-2(1H)-pyrimidinone(25902-95-8)
• EPA Substance Registry System: 4-ethoxy-1-ethyl-2(1H)-pyrimidinone(25902-95-8)

Safety Data

• Hazardous Substances Data: 25902-95-8(Hazardous Substances Data)

Upstream product

• 20461-60-3 2,4-diethoxypyrimidine 
• 75-03-6 ethyl iodide 
• 6220-43-5 4-ethoxypyrimidin-2-one 
• 64-17-5 ethanol 
• 64-67-5 diethyl sulfate 
• 66-22-8 uracil 

Downstream Products

• 6490-42-2 N-1-ethyluracil 

Relevant articles and documents

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HSAB-driven chemoselective N1-alkylation of pyrimidine bases and their 4-methoxy- or 4-acetylamino-derivatives

The lithium salts of the conjugated bases of 4-methoxy- and 4-acetylamino-2(1H)-pyrimidinones 1-3 undergo highly chemoselective N1-methylation or ethylation when treated with methyl- or ethylsulfate (hard electrophiles) in dry dioxane, while the use of DMF as solvent results in competitive O2-alkylation. Potassium salts of the same bases in DMF undergo prevalent O2-attack. Under the same conditions, a similar but less chemoselective behaviour is observed in alkylation of thymine and uracil, where some N3-attack occurs. This can be rationalised in terms of the HSAB principle.