26006-20-2

Usage

InChI:InChI=1/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

Upstream product

• 75-44-5 phosgene 
• 95-80-7 4-methylbenzene-1,3-diamine 
• 201230-82-2 carbon monoxide 
• 121-14-2 2,4-dinitrotoluene 
• 6935-99-5 2,4-bis(methoxycarbonylamino)toluene 
• 60483-66-1 dipropyl (4-methyl-1,3-phenylene)dicarbamate 
• 108-71-4 3,5-diaminotoluene 
• 823-40-5 2,6-toluenediamine 
• 95-70-5 2-methyl-p-phenylenediamine 
• 71412-40-3 N,N'-(4-methyl-m-phenylene)-bis-carbamic acid diisobutyl ester 
• 7450-62-6 2,4-bis-(ethoxycarbonylamino)toluene 
• 124-38-9 carbon dioxide 
• 59255-79-7 O,O'-di-tert-butyl 4-methyl-1,3-phenylenedicarbamate 
• 42592-07-4 diisopropyl (4-methyl-1,3-phenylene)dicarbamate 

Downstream Products

• 93427-59-9 3,3'-(4-methyl-m-phenylene)-bis-oxazolidin-2-one 
• 2131-75-1 N,N'-bis-(aziridine-1-carbonyl)-4-methyl-m-phenylenediamine 
• 102544-18-3 N,N'-(4-methyl-m-phenylene)-bis-carbamic acid bis-(2-piperidino-ethyl ester) 
• 57718-04-4 N,N'-(4-methyl-m-phenylene)-bis-carbamic acid bis-(2-morpholino-ethyl ester) 
• 7402-96-2 N,N'-bis-(2,2-dimethyl-aziridine-1-carbonyl)-4-methyl-m-phenylenediamine 
• 76842-52-9 linalyl 3-isocyanato-4-methylphenylcarbamate 
• 70763-76-7 n-octyl 3-isocyanato-4-methylphenylcarbamate 
• 76842-50-7 n-heptyl 3-isocyanato-4-methylphenylcarbamate 
• 76842-53-0 n-decyl 3-isocyanato-4-methylphenylcarbamate 
• 76842-54-1 α-terpinyl 3-isocyanato-4-methylphenylcarbamate 
• 76842-55-2 bornyl 3-isocyanato-4-methylphenylcarbamate 
• 76842-48-3 n-hexyl 3-isocyanato-4-methylphenylcarbamate 
• 76842-51-8 n-nonyl 3-isocyanato-4-methylphenylcarbamate 
• 7469-49-0 1-methyl-2,4-bis-(butoxycarbonylamino)-benzene 

Relevant academic research and scientific papers

Study on the synthesis of toluene-2,4-diisocyanate via amine and carbonyl fluoride

Abstract We presented recently a synthesis of toluene-2,4-diisocyanate (TDI) as one of the nine examples to verify the feasibility of an industrial appealing two-step method for isocyanates synthesis via amines and carbonyl fluoride (COF2). Because more investigation was considered to be necessary for future industrial application, the two-step synthesis processes of TDI were studied in detail herein. The total yield of TDI increased 5.6% under the optimized experimental conditions. The influence of the excess COF2 left in the reaction system was studied carefully according to a one-pot method.

METHOD FOR PRODUCING CARBAMATE AND METHOD FOR PRODUCING ISOCYANATE

The present invention provides a method for producing a carbamate that includes a step (1) and a step (2) described below: (1) a step of producing a compound (A) having a urea linkage, using an organic primary amine having at least one primary amino group per molecule and at least one compound selected from among carbon dioxide and carbonic acid derivatives, at a temperature lower than the thermal dissociation temperature of the urea linkage; and(2) a step of reacting the compound (A) with a carbonate ester to produce a carbamate.

Synthesis and antitussive activity of obtucarbamate A derivatives

Obtucarbamate A was purified from Disporum cantoniense with good antitussive property. In present work, a series of obtucarbamate A derivatives were designed and synthesized from obtucarbamate A by microwave method, and their antitussive activity were evaluated. The results showed that the toluene diisocyanate was obtained with a yield of 95.1percent using a simple method, 1-methyl-2-pyrrolidinone as solvent, temperature of 190 °C, microwave irradiation at 60 W power for 30 min. All compounds have good antitussive activity, and small steric hindrance unsaturated groups of ester chains and amino groups favor activity. It is the first reported of obtucarbamate A derivatives used as antitussive, and the results provide a basis for the application of obtucarbamate derivatives as new antitussive.

METHOD FOR PRODUCING ISOCYANATES

The invention relates to a method for producing an isocyanate, wherein a carbamate or thiolcarbomate is converted, in the presence of a catalyst, with separation of an alcohol or thioalcohol, at a temperature of at least 150° C., to the corresponding isocyanate, wherein a compound of the general formula (X)(Y)(Z—H) is used as a catalyst, in particular characterized in that the compound has both a proton donor function and a proton acceptor function. In the catalysts according to the invention, a separable proton is bound to a heteroatom, which is more electronegative than carbon. Said heteroatom is either identical to Z or a component thereof. In the catalysts according to the invention, there is additionally a proton acceptor function which is either identical to X or a component thereof. According to the invention, the proton donator and proton acceptor function are connected to each other by the bridge Y.

ISOCYANATE PRODUCTION METHOD

An isocyanate production method according to the present invention is a method in which an isocyanate is produced by subjecting a carbamate to thermal decomposition, and includes: a step of preparing a mixture liquid containing the carbamate, an inactive solvent and a polyisocyanate compound; a step of conducting a thermal decomposition reaction of the carbamate by continuously introducing the mixture liquid into a thermal decomposition reactor; a step of collecting a low-boiling decomposition product by continuously extracting the low-boiling decomposition product in a gaseous state from the reactor, the low-boiling decomposition product having a boiling point lower than the polyisocyanate compound; and a step of collecting a high-boiling component by continuously extracting, from the reactor, a liquid phase component which is not collected in a gaseous state at the step of collecting the low-boiling decomposition product.

Heterogeneous catalyst for the direct carbonylation of nitro aromatic compounds to isocyanates

A process for preparing an aromatic isocyanate by direct carbonylation of a nitro aromatic compound by reacting the nitro aromatic compound with carbon monoxide in the presence of a catalyst, characterized in that the catalyst contains a multi metallic material comprising one or more binary intermetallic phases of the general formula AxBy wherein: A is one or more element selected from Ni, Ru, Rh, Pd, Ir, Pt and Ag, B is one or more element selected from Sn, Sb, Pb, Zn, Ga, In, Ge and As, x is in the range 0.1-10, y in is in the range 0.1-10.

Preparing method of toluene diisocynate

The invention relates to a preparing method of toluene diisocynate. The method includes the steps of adding a catalyst (polyoxometallate) and a solvent into a reaction container, then adding the raw material (2,6-diaminotoluene), phenylsilane, an acid-binding agent and a dehydrating agent to be evenly mixed, finally adding gas-state carbon dioxide, and conducting magnetic stirring and sufficient reacting at a certain temperature to obtain a product. In the method, Anderson type heteropolyacid serves as the catalyst, the catalyst requires mild reaction conditions and is high in specific selectivity, recyclable and friendly to the environment, the industrial reaction cleanliness is improved, the process economy is improved, manufacturing cost and three wastes are reduced, environmental protection pressure is relieved, and industrial production is facilitated.

MULTISTEP PROCESS FOR THE PREPARATION OF HEXAMETHYLENE DIISOCYANATE, PENTAMETHYLENE DIISOCYANATE OR TOLUENE DIISOCYANATE

The present invention relates to a multistep process for the preparation of organic diisocyanates by converting the corresponding diamine precursors, urea and hydroxy compounds into monomeric diurethanes, converting these diurethanes into diurethanes of high boiling hydroxy compounds, and finally cleavage of the latter diurethanes to form the diisocyanates and recover the high boiling hydroxy compounds.

Fluoride-Catalyzed Deblocking: A Route to Polymeric Urethanes

We report a fluoride-catalyzed deblocking of urethanes as “blocked” isocyanates. Organic and inorganic sources of fluoride ion proved effective for deblocking urethanes and for converting polyurethanes to small molecules. Distinct from conventional deblocking chemistry involving organometallic compounds and high temperatures, the method we describe is metal-free and operates at or slightly above room temperature. The use of fluorescent blocking agents enabled visual and spectroscopic monitoring of blocking/deblocking reactions, and the selected conditions proved applicable to urethanes containing a variety of blocking groups. The method additionally enabled a one pot deblocking and polymerization with α,ω-diols. Overall, this deblocking/polymerization strategy offers a convenient and efficient solution to problems that have limited the breadth of applications of polyurethane chemistry.

Reaction method accompanied by production of gas component

The present invention relates to a reaction method comprising a step of supplying a liquid containing at least one raw material compound and a low-boiling compound having a standard boiling point lower than a standard boiling point of the raw material compound to a flow channel, a step of heating the liquid to produce a liquid reaction product and a gas component by a reaction of the raw material compound, and a step of separating a liquid phase containing the reaction product from a gas phase containing the gas component and the low-boiling compound.