26883-70-5

Usage

Uses

Used in Specialty Polymer Production:
Trans-1,3-Cyclohexanediamine is utilized as a key component in the synthesis of specialty polymers, such as nylon and polyurethane. Its presence in these materials contributes to their unique properties and performance characteristics.
Used as a Curing Agent in Epoxy Resins:
In the field of adhesives and coatings, Trans-1,3-Cyclohexanediamine serves as an effective curing agent for epoxy resins. This application enhances the hardness, strength, and durability of the final product.
Used as a Corrosion Inhibitor in Metal Coatings:
Trans-1,3-Cyclohexanediamine is employed as a corrosion inhibitor in metal coatings, protecting the underlying metal from environmental factors that could lead to degradation and rust.
Used in Pharmaceutical Research:
The potential role of Trans-1,3-Cyclohexanediamine in pharmaceuticals is currently being explored. Its unique chemical properties may contribute to the development of new drugs and therapies.
Used as a Chelating Agent in Chemical Processes:
Trans-1,3-Cyclohexanediamine also functions as a chelating agent in various chemical processes. This application aids in the separation and purification of metal ions, making it a valuable tool in chemical engineering and analysis.

Upstream product

• 2802-07-5 1,3-cyclohexanedionedioxime 
• 99-09-2 3-nitro-aniline 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 
• 3385-21-5 1,3-diaminocyclohexane 
• 141-78-6 ethyl acetate 
• 10268-78-7 1,3-diacetylaminobenzene 
• 108-45-2 m-phenylenediamine 
• 82166-21-0 methyl cyclohexane 
• 32189-20-1 trans-N,N'-bis(acetyl)cyclohexane-1,3-diamine 
• 1634-04-4 tert-butyl methyl ether 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1165952-91-9 cyclohexa-1,3-diene 
• 3385-21-5 trans-cyclohexane-1,3-diamine 
• 347186-01-0 N-(3-aminocyclohexyl)(t-butoxy)carboxamide 
• 645400-45-9 N-(6-methoxy-4-methylquinolin-2-yl)cyclohexane-1,3-diamine 
• 860297-18-3 2-[(3-aminocyclohexyl)amino]-N,N-dimethylquinoline-4-carboxamide 
• 860297-23-0 N₂-(3-aminocyclohexyl)-N₆,N₆-dimethylquinoline-2,6-diamine 
• 1000417-94-6 N-(6-chloroquinolin-2-yl)cyclohexane-1,3-diamine 
• 347185-28-8 (3-Aminocyclohexyl)(phenylsulfonyl)amine 
• 921590-99-0 N-(3-aminocyclohexyl)-5-[4-(benzyloxy)phenyl]-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1788036-28-1 (±)-cis-N-(tert-butoxycarbonyl)-1,3-cyclohexanediamine 
• 1788036-28-1 tert-butyl (3-aminocyclohexyl)carbamate 
• 1016495-70-7 C₈H₁₆N₂O 
• 860351-60-6 (1S,3S)-cyclohexane-1,3-diamine 
• 3385-21-5 trans-1,3-cyclohexanediamine 

Relevant academic research and scientific papers

Synthesis method of weather-resistant epoxy resin curing agent

The invention discloses a synthesis method of a weather-resistant epoxy resin curing agent. The method comprises the following steps of: enabling cyclohexanedicarboxylic acid and azidoformic acid 2, 2, 2-trichloroethyl ester to react under the catalysis of DMAP and copper acetate to generate an intermediate b, and enabling the intermediate b to react with potassium carbonate to generate 1, 3-bis (aminomethyl) cyclohexane. According to a traditional synthesis method of 1, 3-bis (aminomethyl) cyclohexane, m-xylylenediamine (MXDA) is subjected to benzene ring hydrogenation reduction to prepare the 1, 3-bis (aminomethyl) cyclohexane. The invention provides the novel synthesis method of 1, 3-bis (aminomethyl) cyclohexane (1, 3-BAC), and the method is simple in process.

Ru/g-C3N4as an efficient catalyst for selective hydrogenation of aromatic diamines to alicyclic diamines

A series of Ru/g-C3N4materials with highly dispersed Ru were firstly prepared by an ultrasonic impregnation method using carbon nitride as a support. The catalysts were characterized by various techniques including BET and elemental analysis, ICP-AES, XPS, XRD, CO2-TPD and TEM. The results demonstrated that Ru/g-C3N4materials with a mesoporous structure and highly dispersed Ru were successfully prepared. The chemo-selective hydrogenation ofp-phenylenediamine (PPDA) to 1,4-cyclohexanediamine (CHDA) over Ru/g-C3N4as a model reaction was investigated in detail. PPDA conversion of 100% with a CHDA selectivity of more than 86% could be achieved under mild conditions. It can be inferred that the carbon nitride support possessed abundant basic sites and the Ru/g-C3N4-Tcatalysts provided suitable basicity for the aromatic ring hydrogenation. Compared to the N-free Ru/C catalyst, the involvement of nitrogen species in Ru/g-C3N4remarkably improved the catalytic performance. In addition, the recyclability of the catalyst demonstrated that the aggregation of Ru nanoparticles was responsible for the decrease of the catalytic activity. Furthermore, this strategy also could be expanded to the selective hydrogenation of other aromatic diamines to alicyclic diamines.

Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators

A novel series of trans-1,3-cyclohexyl diamides was discovered and characterized as mGluR5 negative allosteric modulators (NAMs) lacking an alkyne moiety. Conformational constraint of one of the amide bonds in the diamide template led to a spirooxazoline template. A representative compound (24d) showed good in vitro potency, high CNS penetration and, upon subcutaneous dosing, demonstrated efficacy in the mouse marble burying test, generally used as indicative of potential anxiolytic activity.

Absorption medium and method for removing sour gases from fluid streams, in particular from flue gases

Absorption medium for acid gases comprising an oligoamine (A) of the general formula (I) and a primary or secondary alkanolamine (B) of the general formula (II) in which the weight ratio of oligoamine (A) to the primary or secondary alkanolamine (B) is 0.2 to 4, and also the process for removing acid gases from a gas stream by contacting the gas stream at a pressure of 0.05 to 10 MPa abs with an aqueous solution brought to and maintained at a temperature of 20 to 80° C. of said absorption medium.

Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists

We herein report the optimization of cyclopentane- and cyclohexane-1,3-diamine derivatives as novel and potent MCH-R1 antagonists. Structural modifications of the 2-amino-quinoline and thiophene moieties found in the initial lead compound served to improve its metabolic stability profile and MCH-R1 affinity, and revealed unprecedented SAR when compared to other 2-amino-quinoline-containing MCH-R1 antagonists.

Insights into the van der Waals radius of low-spin Ni(II) from molecular mechanics studies and the crystal structures of [Ni(cis-cyclohexane-1,3-diamine)2]Cl2, [Ni{(R)-5,5,7-trimethyl-1,4-diazacycloheptane}2]Cl2 ·H2O and [Ni(5,7-dimethyl-1,4-diazacycloheptane)2](ClO4)2

The structures of three bis(diamine)nickel(II) complexes, chosen to shed light on the van der Waals radius of nickel(II), are described. [Ni(cis-1,3-chxn)2]Cl2 (cis-1,3-chxn = cis-cyclohexane-1,3-diamine) crystallizes in the monoclinic space group P21/n, with a 6.397(2), b 16.463(4), c 7.229(2) A, b 90.70(2)°, and its structure has been refined to an R value of 0.031 on 1214F. [Ni{(R)-tmdz}2]Cl2·H2O (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) crystallizes in the orthorhombic space group P212121, with a 10.678(1), b 11.073(5), c 17.968(6) A, and its structure has been refined to an R value of 0.031 on 1586F. [Ni(dmdz)2](ClO4)2 (dmdz = 5,7-dimethyl-1,4-diazacycloheptane) crystallizes in the monoclinic space group P21/n, with a 9.582(1), b 10.390(2), c 11.817(3) A, β 96.19(2)°, and its structure has been refined to an R value of 0.059 on 817F. In all three structures, short Ni-...H and Ni...C interactions, ranging from 2.37 to 2.61 A and 2.99 to 3.03 A, respectively, are observed. Using molecular mechanics modelling to reproduce these separations, we have arrived at a van der Waals radius of 1.35 A for low-spin nickel(II). Analysis of Ni...O contacts in the solid state leads to a van der Waals radius of about 1.26 A, which is consistent with the molecular mechanics derived value since these are usually longer.

N,N-bis (quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials

Disclosed are N,N'-bis(quinolin-4-yl)diamine derivatives of general formula I wherein R1 signifies halogen or trifluoromethyl, R2 signifies hydrogen or halogen, A signifies cyclohexane-1,3-diyl, 2-methyl-cyclohexane-1,3-diyl, cyclohexane-1,4-diyl, dicyclohexylmethane-4,4'-diyl, cyclopentane-1,3-diyl, phenylene-1,4, phenylene-1,3 and phenylene-1,2; n is 1 or 2; m is 1 or 2, as well as their pharmaceutically acceptable salts. These products are useful as agents for preventing malaria and for treating it, especially where the pathogens are resistant to chloroquine. STR1