27257-07-4

Basic information

• Product Name: Acetic acid 2,4-dimethoxyphenyl ester
• Synonyms: 2,4-Dimethoxyphenol acetate;Acetic acid 2,4-dimethoxyphenyl ester
• CAS NO: 27257-07-4
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.2
• Mol File: 27257-07-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 39 °C
• Boiling Point: 262.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.120±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Acetic acid 2,4-dimethoxyphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 2,4-dimethoxyphenyl ester(27257-07-4)
• EPA Substance Registry System: Acetic acid 2,4-dimethoxyphenyl ester(27257-07-4)

Safety Data

• Hazardous Substances Data: 27257-07-4(Hazardous Substances Data)

Upstream product

• 13330-65-9 2,4-dimethoxyphenol 
• 108-24-7 acetic anhydride 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 64-19-7 acetic acid 
• 151-10-0 1,3-Dimethoxybenzene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 1185-59-7 tetraethylammonium acetate 
• 2880-58-2 2-methoxy-1,4-benzoquinone 
• 121-45-9 phosphorous acid trimethyl ester 
• 94420-70-9 dimethyl 2,4-dimethoxyphenyl phosphate 
• 103262-85-7 4-acetoxy-3-methoxyphenol 
• 74-88-4 methyl iodide 

Downstream Products

• 13330-65-9 2,4-dimethoxyphenol 
• 91061-75-5 1-(5-hydroxy-2,4-dimethoxy-phenyl)-ethanone 
• 156114-96-4 5-acetoxy-2,4-dimethoxybenzaldehyde 

Relevant articles and documents

Direct Acetoxylation of Arenes

Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.

Gold-catalyzed oxidative acyloxylation of arenes

A variety of nonactivated hindered aromatic rings are acyloxylated (22 examples, up to 83% yield) in the presence of PPh3AuCl as the catalyst and di(acetoxy)iodobenzene as the oxidant. The reaction proceeds at 110 °C in an acid media and allows the formation of both hindered acetoxy and acyloxy derivatives. This methodology nicely complements the Pd-catalyzed arene acyloxylation reaction, which is not operating on hindered substrates and allows the Au-catalyzed unprecedented acyloxylation reaction of arenes, implying various carboxylic acids.

Electrophilic components in the electrochemical acetoxylation of substituted arenes

The mechanism of anodic acetoxylation of substituted arenes under conditions of undivided galvanostatic electrolysis in MeCN containing acetate is suggested and an important role of electrophilic components (AcOH or ZnCl2) catalyzing transformation of intermediate ipso-acetoxylated polysubstituted arenonium cations to corresponding ortho-acetoxylated arenonium cations, which give acetoxylation products after deprotonation, is experimentally proved.