27274-31-3

Basic information

• Product Name: Allyloxypolyethyleneglycol
• Synonyms: Polyethylene glycol monoallyl ether;allyloxypolyethyleneglycol;Poly(oxy-1,2-ethanediyl), .alpha.-2-propenyl-.omega.-hydroxy-;Allyloxy(polyethylene oxide) (2-6 EO);Allyloxy(polyethylene oxide) (8-12 EO);Monoallylether Ethoxylate EO 9 + EO 10 (Neo 9/10);Allyloxypolyethyleneglycol(APEG);Allyloxy(polyethylene oxide) (20-30 EO)
• CAS NO: 27274-31-3
• Molecular Formula: C5H10O2
• Molecular Weight: 102.1317
• Product Categories: construction,water reducing agent
• Mol File: 27274-31-3.mol
• Article Data: 70

Chemical Properties

• Melting Point: 20-25°C
• Boiling Point: 90.2oC at 760mmHg
• Flash Point: 4.4oC
• Appearance: /
• Density: 0.762g/cm3
• Refractive Index: 1.465
• CAS DataBase Reference: Allyloxypolyethyleneglycol(CAS DataBase Reference)
• NIST Chemistry Reference: Allyloxypolyethyleneglycol(27274-31-3)
• EPA Substance Registry System: Allyloxypolyethyleneglycol(27274-31-3)

Safety Data

• Hazardous Substances Data: 27274-31-3(Hazardous Substances Data)

Usage

General Description

Allyloxypolyethyleneglycol is a compound containing allyl and ethylene glycol units. It is a versatile chemical used in a variety of applications including as a reactive intermediate in the synthesis of polymers, surfactants, and pharmaceuticals. Allyloxypolyethyleneglycol has a wide range of solubility and can be used as a dispersant, emulsifier, and lubricant. Its properties make it suitable for use in various industries, including cosmetics, personal care products, and industrial formulations. Additionally, allyloxypolyethyleneglycol is known for its ability to improve the stability and effectiveness of other chemical compounds, making it a valuable additive in many different products.

InChI:InChI=1/C5H10O2/c1-2-4-7-5-3-6/h2,6H,1,3-5H2

Upstream product

• 75-21-8 oxirane 
• 107-18-6 allyl alcohol 
• 821-09-0 n-Pent-4-enyl alcohol 
• 109126-88-7 bis(2-(2-propenyloxy)ethyl) maleate 
• 901-44-0 dyanol 22 
• 3973-18-0 2-(prop-2-ynyloxy)ethanol 
• 107-05-1 3-chloroprop-1-ene 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 112-60-7 Tetraethylene glycol 
• 64818-35-5 4-pentenyl mesylate 
• 153901-22-5 methanesulfonic acid 2-propenyloxyethyl ester 
• 4792-15-8 Pentaethylene glycol 
• 106-95-6 allyl bromide 
• 727986-30-3 2-(2-(2-(allyloxy)ethoxy)ethoxy)tetrahydro-2H-pyran 

Downstream Products

• 116983-87-0 maleic acid-(2-allyloxy-ethyl ester)-methyl ester 
• 15424-04-1 2-(allyloxy)ethyl bromide 
• 70964-99-7 acetic acid 2-allyloxyethyl ester 
• 40762-37-6 1-(2-Cyan-ethoxy)-2-allyloxy-ethan 
• 91213-71-7 2-(3-(2-Hydroxy-ethoxy)-propyl)-cyclohexanon 
• 144685-36-9 2-(3-Diphenylphosphanyl-propoxy)-ethanol 
• 144685-38-1 2-[2-(3-Diphenylphosphanyl-propoxy)-ethoxy]-ethanol 
• 144685-40-5 2-{2-[2-(3-Diphenylphosphanyl-propoxy)-ethoxy]-ethoxy}-ethanol 
• 188650-07-9 2-Amino-benzoic acid 2-allyloxy-ethyl ester 
• 188650-08-0 2-Amino-benzoic acid 2-(2-allyloxy-ethoxy)-ethyl ester 
• 87048-16-6 2-(2-(2-(2-(2-(2-allyloxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethan-1-ol 
• 87048-14-4 2-(2-(2-(2-(2-allyloxyethoxy)ethoxy)ethoxy)ethoxy)ethan-1-ol 
• 391675-16-4 mono-2-allyloxyethyl fumarate 
• 26150-05-0 2-(2-(2-(allyloxy)ethoxy)ethoxy)ethanol 

Relevant articles and documents

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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently degrade a target protein within cells can be a lengthy and unpredictable process, and it remains unclear whether any combination of E3 and target might be productive for degradation. We describe a probe-quality degrader for a ligase-target pair deemed unsuitable: the von Hippel-Lindau (VHL) and BRD9, a bromodomain-containing subunit of the SWI/SNF chromatin remodeling complex BAF. VHL-based degraders could be optimized from suboptimal compounds in two rounds by systematically varying conjugation patterns and linkers and monitoring cellular degradation activities, kinetic profiles, and ubiquitination, as well as ternary complex formation thermodynamics. The emerged structure-activity relationships guided the discovery of VZ185, a potent, fast, and selective degrader of BRD9 and of its close homolog BRD7. Our findings qualify a new chemical tool for BRD7/9 knockdown and provide a roadmap for PROTAC development against seemingly incompatible target-ligase combinations.