27798-53-4

Basic information

• Product Name: 3-Methoxy-4-[(trimethylsilyl)oxy]benzoic acid methyl ester
• Synonyms: 3-Methoxy-4-[(trimethylsilyl)oxy]benzoic acid methyl ester;4-[(Trimethylsilyl)oxy]-m-anisic acid methyl ester
• CAS NO: 27798-53-4
• Molecular Formula: C₁₂H₁₈O₄Si
• Molecular Weight: 254.35
• Mol File: 27798-53-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Methoxy-4-[(trimethylsilyl)oxy]benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-4-[(trimethylsilyl)oxy]benzoic acid methyl ester(27798-53-4)
• EPA Substance Registry System: 3-Methoxy-4-[(trimethylsilyl)oxy]benzoic acid methyl ester(27798-53-4)

Safety Data

• Hazardous Substances Data: 27798-53-4(Hazardous Substances Data)

Usage

Usage

Organic synthesis, medicinal chemistry

Composition

Derivative of benzoic acid with a methoxy group and a trimethylsilyloxy group attached to the benzene ring

Applications

Preparation of pharmaceuticals, agrochemicals, and other biologically active molecules; building block for the synthesis of complex organic compounds

Functional Group

Methoxy group (-OCH3), trimethylsilyloxy group (-OSi(CH3)3)

Protective Function

Trimethylsilyloxy group can protect the carboxylic acid functionality, enabling selective transformations in organic chemistry.

Upstream product

• 67-56-1 methanol 
• 1000180-41-5 2-(4-hydroxy-3-methoxyphenyl)-2-methoxyacetonitrile 
• 24589-78-4 N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 10416-58-7 N,N-bis(trimethylsilyl)acetamide 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 

Relevant articles and documents

Chemical defense of the crust fungus Aleurodiscus amorphus by a tailor-made cyanogenic cyanohydrin ether

(Chemical Equation Presented) A mighty midget! When injured, the crust fungus A. amorphus (left in the picture) releases hydrocyanic acid by an oxidative mechanism so far unknown in nature. In contrast to cyanogenic glycosides in which the smooth hydrolysis of the glycoside bond is essential for the liberation of hydrocyanic acid, in aleurodisconitrile the oxidation-prone aromatic moiety enables the release of hydrocyanic acid.

29Si and 13C NMR Spectra of 4-Substituted 2-Methoxytrimethylsiloxybenzenes. Factors Determining the Chemical Shifts in Models of Lignin Constituents

29Si and 13C NMR chemical shifts are reported for a series of twenty 4-substituted 2-methoxytrimethylsiloxybenzenes; the set of substituents incorporates a basic set of ten substituents differing in their relative polar and resonance effects and ten other