28122-15-8Relevant articles and documents
Organocatalytic Enantioselective Selenosulfonylation of a C-C Double Bond to Form Two Stereogenic Centers in an Aqueous Medium
Chen, Zhili,Hu, Fangli,Huang, Shengli,Zhao, Zhengxing,Mao, Hui,Qin, Wenling
, p. 8100 - 8111 (2019/06/17)
Organocatalytic selenosulfonylation of the C-C double bond of α,β-unsaturated ketones to construct two contiguous stereogenic centers in an aqueous medium was described. A series of α-selenyl and β-sulfonyl ketones with various functional groups were synthesized in good yields and enantioselectivities with saturated NaCl solution as the solvent. In addition, this protocol had been successfully scaled up to a decagram scale via a simple workup procedure.
Synthesis of Enones and Enals via Dehydrogenation of Saturated Ketones and Aldehydes
Pan, Gao-Fei,Zhu, Xue-Qing,Guo, Rui-Li,Gao, Ya-Ru,Wang, Yong-Qiang
, p. 4774 - 4783 (2018/11/10)
A general, efficient and economic palladium-catalyzed dehydrogenation to form enones or enals has been developed. The approach possesses extremely broad substrate scope including various linear or cyclic saturated ketones and aldehydes. The protocol is ligand-free, and molecular oxygen is used as the sole clean oxidant in the reaction. Due to mild reaction conditions, good functional group compatibility, and versatile utilities of enones and enals, the method can be applied in the late-stage synthesis of natural products, pharmaceuticals and fine chemicals. (Figure presented.).
Environment-friendly method for synthesizing propenyl ketone compound
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Paragraph 0019; 0029, (2019/01/04)
The invention discloses an environment-friendly method for synthesizing a propenyl ketone compound. The method comprises the following steps: subjecting an aldehyde compound and allyl bromide to a Barbier reaction in the presence of metal powder, so as to obtain an allyl alcohol compound; and subjecting the allyl alcohol compound to a structural isomerization reaction in the presence of a catalyst, thereby obtaining the propenyl ketone compound. The method disclosed by the invention has the advantages of short synthesis route, mild reaction conditions, simplicity in operation, readily available raw materials, and the like and has relatively high academic research value and market economy significance.
Synthesis of Z-alkenes from Rh(I)-catalyzed olefin isomerization of β,γ-unsaturated ketones
Zhuo, Lian-Gang,Yao, Zhong-Ke,Yu, Zhi-Xiang
, p. 4634 - 4637 (2013/10/08)
Developing olefin isomerization reactions to reach kinetically controlled Z-alkenes is challenging because formation of trans-alkenes is thermodynamically favored under the traditional catalytic conditions using acids, bases, or transition metals as the catalysts. A new synthesis of Z-alkenes from Rh(I)-catalyzed olefin isomerization of β,γ-unsaturated ketones to α,β-unsaturated ketones was developed, providing an easy and efficient way to access various Z-enones.
Decarboxylative allylation of arylglyoxylic acids with allyl alcohol
Grünberg, Matthias F.,Goo?en, Lukas J.
, p. 140 - 143 (2013/10/01)
A decarboxylative allylation of arylglyoxylic acids with allyl alcohol has been developed. In the presence of catalytic amounts of Pd(dba) 2 and PPh3, the substrates are in an esterification equilibrium with the allyl arylglyoxylates, which are continuously decarboxylated to give α,β-unsaturated ketones along with CO2 and water as the only byproducts.
Decarboxylative allylation of glyoxylic acids with diallyl carbonate
Manjolinho, Filipe,Gruenberg, Matthias F.,Rodriguez, Nuria,Goossen, Lukas J.
supporting information; experimental part, p. 4680 - 4683 (2012/10/08)
A catalyst system consisting of Pd(PPh3)4 and P(pTol)3 was found to effectively promote the intermolecular decarboxylative coupling of α-oxocarboxylic acids with diallyl carbonate to give α,β-unsaturated ketones. The key advantage of the new reaction protocol is that preformation of the allyl esters is not required. The reaction is believed to proceed via phosphane-mediated decarboxylation of the α-oxocarboxylates, leading to acyl anion equivalents that are allylated within the coordination sphere of the palladium catalyst. Under the reaction conditions, the double bond then migrates into conjugation with the carbonyl group. Copyright
A new organic transformation by introducing crotyl/allyltrifluoroborates in cross-coupling reaction with aroyl chlorides
Al-Masum, Mohammad,Liu, Kwei-Yu
supporting information; experimental part, p. 5090 - 5093 (2011/10/19)
Microwave irradiated PdCl2(dtbpf) catalyzed direct cross-coupling reaction of aroyl chlorides with potassium crotyl/ allyltrifluoroborates has been developed. Regioselectivity of the cross-coupling product is varied from crotyltrifluoroborate to allyltrifluoroborate.
CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1
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Page/Page column 209-210, (2009/03/07)
This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih); (Ii); (Ij), (Ik), (II) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
INSECTICIDAL TETRAHYDROINDENOPYRIDINE DERIVATIVES
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Page/Page column 15; 27, (2008/06/13)
Certain tetrahydroindenylpyridine derivatives provide unexpected insecticidal and acaricidal activity. These compounds are represented by formula (I); wherein R, R1, R2, and R3 are fully described herein. In addition, comp
Can simple enones be useful partners for the catalytic stereoselective alkylation of indoles?
Bandini, Marco,Fagioli, Matteo,Garavelli, Marco,Melloni, Alfonso,Trigari, Valerio,Umani-Ronchi, Achille
, p. 7511 - 7518 (2007/10/03)
A new catalytic system for the first example of enantioselective Friedel-Crafts-type (FC) addition of indoles to simple enones is described. The use of an equimolar amount of chiral [Al(salen)Cl] and 2,6-lutidine (10 mol%) was found to be effective in pro