93361-25-2

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 1793-07-3 methyl 2-isocyanatobenzoate 
• 19164-60-4 7-methylbicyclo[4.2.0]octa-1,3,5-trien-7-ol 
• 29539-21-7 3-methylisocoumarin 
• 2852-91-7 (2-carboxyphenyl)acetone 
• 67-56-1 methanol 
• 93361-24-1 2-(3-methyl-1-oxoisoquinolin-2(1H)-yl)benzonitrile 

Relevant academic research and scientific papers

Expeditious Synthesis of Isoquinolone Derivatives by Rhodium(I)-Catalyzed Annulation Reaction through C-C Bond Cleavage

A Rh(I)-catalyzed intermolecular cyclization between isocyanates and benzocyclobutenols leading to isoquinolin-1(2H)-ones through selective cleavage of a C-C bond has been realized. Exploiting the same strategy, we developed a Rh(I)-catalyzed three-component reaction of benzocyclobutenols, isonitriles, and sulfonyl azides to access isoquinolin-1(2H)-imines. These procedures provide unique and expeditious access to isoquinolone derivatives which are otherwise difficult to prepare in satisfactory yields with excellent functional-group tolerance under mild reaction conditions.

Studies on 4(1H)-Quinazolinones. IV. Convenient Syntheses of 12-Methyl-6H-isoquinoquinazolin-6-one and 6-Methyl-13H-quinazolinoquinazolin-13-one

Two novel ring systems, 12-methyl-6H-isoquinoquinazolin-6-one (2) and 6-methyl-13H-quinazolinoquinazolin-13-one (3a), were synthesized.Reaction of 3-methylisocoumarin (4) with 2-cyanoaniline gave 2-(2-cyanophenyl)-3-methylisocarbostyril (5),