28697-09-8Relevant articles and documents
TUBULYSIN DERIVATIVES AND METHODS FOR PREPARING THE SAME
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Page/Page column 29, (2020/02/16)
The invention relates to novel means and methods for the synthesis of tubulysin and derivatives thereof, which find their use e.g. as cytotoxic agents in targeted drug delivery. Provided is a method for preparing a tubulysin derivative, comprising reacting compounds A, B and C in a 3- component Passerini reaction, wherein compound A is a carboxylic acid according to the general formula (A); wherein compound B is an aldehyde according to the general formula (B); and wherein compound C is an isocyanide according to the general formula (C).
ANTITHROMBOTIC AGENTS
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, (2008/06/13)
This invention relates to L-arginine aldehyde derivatives, having the formula I STR1 where X and Y have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitor
A short enantioselective synthesis of pipecolic acid
Fernandez-Garcia,McKervey
, p. 2905 - 2906 (2007/10/03)
A simple enantioselective route to pipecolic acid is described. The key step involves the Sharpless asymmetric epoxidation of an N-protected aminoheptenol which spontaneously cyclises to a piperidine derivative on deprotection.