287384-84-3

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 6-CHLORO-7-AZAINDOLE-2-CARBOXYLATE is used as a key intermediate for the synthesis of various pharmaceutical drugs. Its unique chemical structure and potential biological activities make it a promising candidate for the development of new therapeutic agents.
Used in Cancer Treatment:
ETHYL 6-CHLORO-7-AZAINDOLE-2-CARBOXYLATE is used as a potential therapeutic agent for the treatment of various types of cancer. Its biological activities have been studied for their ability to target and inhibit the growth of cancer cells, making it a valuable compound in the development of anticancer drugs.
Used in Neurological Disorders Treatment:
ETHYL 6-CHLORO-7-AZAINDOLE-2-CARBOXYLATE is also used as a potential therapeutic agent for the treatment of neurological disorders. Its biological activities have been studied for their potential to modulate neuronal signaling pathways and protect against neurodegeneration, offering new avenues for the development of treatments for neurological conditions.
Used in Organic Synthesis:
ETHYL 6-CHLORO-7-AZAINDOLE-2-CARBOXYLATE is used as a building block in the synthesis of various heterocyclic compounds. Its unique chemical structure allows for the formation of diverse molecular architectures, making it a valuable intermediate in the development of new organic compounds with potential applications in various fields, including materials science, pharmaceuticals, and agrochemicals.

InChI:InChI=1/C10H9ClN2O2/c1-2-15-10(14)7-5-6-3-4-8(11)13-9(6)12-7/h3-5H,2H2,1H3,(H,12,13)

Upstream product

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• 221675-35-0 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 880491-19-0 6-chloro-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 577711-90-1 7-oxy-pyrrolo[2,3-b]pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 577711-88-7 1-(tert-butyl) 2-ethyl 1H-pyrrolo[2,3-b]pyridine-1,2-dicarboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Synthesis and biological evaluation of novel hexahydro-pyrido[3′, 2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists

Further lead optimization efforts on previously described 1,2,3,4,10,10a-hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of 5,5a,6,7,8,9-hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines culminating in the discovery of (5aR,9R)-2-[(cyclopropylmethoxy)methyl]-5,5a,6, 7,8,9-hexahydro-9-methyl-pyrido[3′, 2′:4,5]pyrrolo[1,2-a]pyrazine 18 as a potent, full 5-HT2C receptor agonist with an outstanding selectivity profile and excellent hERG and phospholipidosis properties.

PYRAZINO(AZA)INDOLE DERIVATIVES

Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; ca