287974-84-9

Upstream product

• 1333110-92-1 C₂₀H₂₂O₅ 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 118806-75-0 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid 
• 171818-87-4 3-hydroxy-3-(4-methoxy-phenyl)-4-phenyl-butyric acid ethyl ester 
• 171818-88-5 ethyl 3-(4-methoxyphenyl)-4-phenylbutanoate 
• 100-66-3 methoxybenzene 
• 118806-78-3 3-(4-methoxyphenyl)-4-phenylbutanoic acid 
• 61696-79-5 3,4-dihydro-3-(4-methoxyphenyl)naphthalene-1(2H)-one 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 90035-32-8 3-(4-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 

Downstream Products

• 807609-63-8 1-bromo-3-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-1,2,3,4-tetrahydro-naphthalene 
• 103772-30-1 1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]naphthalen-1-ol 

Relevant academic research and scientific papers

Simple synthesis and biological evaluation of flocoumafen and its structural isomers

Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 μM in vitro, while no significant effect for neurotoxicity in cultured cortical neurons. Indian Academy of Sciences.

Synthesis and antitumor activity of 4-hydroxycoumarin derivatives

A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity against five human tumor cell lines. A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity.