2892-99-1

Upstream product

• 100-42-5 styrene 
• 100-52-7 benzaldehyde 
• 91-03-2 3-dimethylamino-2-methyl-1-phenyl-propan-1-one 
• 712-50-5 Cyclohexyl phenyl ketone 
• 74-88-4 methyl iodide 
• 57992-31-1 (1-methyl-cyclohex-3-enyl)-phenyl ketone 
• 2890-61-1 1-methyl-1-cyclohexancarboxylic acid chloride 
• 71-43-2 benzene 
• 1123-25-7 1-methyl-1-cyclohexanecarboxylic acid 
• 865241-08-3 C₁₀H₁₉NO₂ 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1123-24-6 1-methyl-cyclohexylcarboxamide 
• 3183-57-1 1-(1-phenylcyclohexyl)ethanone 
• 591-49-1 1-methylcyclohex-1-ene 
• 2919-23-5 cyclobutanol 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

We found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ketones. The mild and transition-metal-free reaction conditions are attractive features of this method. The power of this protocol was demonstrated by the functionalization of pharmaceutical drugs and natural product. A reaction pathway involving single electron transfer from an enolate form of Breslow intermediate to a redox ester followed by recombination of the resultant radical pair to form a carbon-carbon bond is proposed.

N-Heterocyclic Carbene-Catalyzed Radical Relay Enabling Vicinal Alkylacylation of Alkenes

The N-heterocyclic carbene-catalyzed radical relay enables the vicinal alkylacylation of styrenes, acrylates and acrylonitrile using aldehydes and tertiary alkyl carboxylic acid-derived redox-active esters. This protocol introduces tertiary alkyl groups and acyl groups to C-C double bonds with complete regioselectivity to produce functionalized ketone derivatives. The radical relay mechanism involves single electron transfer from the enolate form of a Breslow intermediate and radical addition of the resultant alkyl radical to the alkene followed by radical-radical coupling.

Restricted rotation due to the lack of free space within a capsule translates into product selectivity: Photochemistry of cyclohexyl phenyl ketones within a water-soluble organic capsule

The rotational mobility of organic guest molecules when included within a confined capsule is restricted and this feature could be translated into product selectivity as established with the photochemical behavior of cyclohexyl phenyl ketones. The Royal Society of Chemistry.